sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 2gr2 | APR | Ferredoxin reductase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 2gr2 | APR | Ferredoxin reductase | / | 1.000 | |
| 2gr0 | ADP | Ferredoxin reductase | / | 0.707 | |
| 4h4w | NAP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.532 | |
| 2yvj | NAI | Ferredoxin reductase | / | 0.518 | |
| 1f3p | NAD | Ferredoxin reductase | / | 0.516 | |
| 4h4y | NAP | Biphenyl dioxygenase ferredoxin reductase subunit | / | 0.482 | |
| 1gil | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.476 | |
| 1u7h | NAD | Putative ornithine cyclodeaminase | / | 0.468 | |
| 4hle | 17V | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform | 2.7.1.153 | 0.468 | |
| 3n7u | NAD | Formate dehydrogenase, chloroplastic/mitochondrial | / | 0.466 | |
| 5ccy | TMP | Polymerase acidic protein | / | 0.466 | |
| 1ydt | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.465 | |
| 2a0y | DIH | Purine nucleoside phosphorylase | 2.4.2.1 | 0.464 | |
| 3ely | SAH | Methyltransferase | / | 0.462 | |
| 4opg | FDA | Conserved Archaeal protein | / | 0.460 | |
| 3e2s | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.459 | |
| 1q8u | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.458 | |
| 4h3f | 10O | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 1ksz | PGS | Adenylosuccinate synthetase | / | 0.455 | |
| 2uzw | SS4 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.455 | |
| 3isj | A8D | Pantothenate synthetase | 6.3.2.1 | 0.455 | |
| 4h3j | 10W | Beta-secretase 1 | 3.4.23.46 | 0.455 | |
| 4ntd | FAD | Thioredoxin reductase | / | 0.454 | |
| 1o94 | ADP | Trimethylamine dehydrogenase | 1.5.8.2 | 0.452 | |
| 1fwk | ADP | Homoserine kinase | 2.7.1.39 | 0.451 | |
| 1rdw | LAR | Actin, alpha skeletal muscle | / | 0.451 | |
| 2fzk | CTP | Aspartate carbamoyltransferase regulatory chain | / | 0.450 | |
| 4b99 | R4L | Mitogen-activated protein kinase 7 | 2.7.11.24 | 0.450 | |
| 1djq | ADP | Trimethylamine dehydrogenase | 1.5.8.2 | 0.449 | |
| 1u33 | LM2 | Pancreatic alpha-amylase | / | 0.449 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.449 | |
| 2xbj | XBJ | Serine/threonine-protein kinase Chk2 | 2.7.11.1 | 0.449 | |
| 1djn | ADP | Trimethylamine dehydrogenase | 1.5.8.2 | 0.448 | |
| 1mei | XMP | Inosine-5'-monophosphate dehydrogenase | / | 0.448 | |
| 2ym2 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.448 | |
| 4kx6 | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.448 | |
| 2tmd | ADP | Trimethylamine dehydrogenase | 1.5.8.2 | 0.447 | |
| 3ohh | 3HH | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4m5p | FMN | NADPH dehydrogenase | / | 0.447 | |
| 1gia | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.446 | |
| 1p9w | ANP | Type II secretion system protein E | / | 0.446 | |
| 2ym1 | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.446 | |
| 5c3j | FAD | Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial | / | 0.446 | |
| 2jkv | NAP | 6-phosphogluconate dehydrogenase, decarboxylating | 1.1.1.44 | 0.445 | |
| 1d4d | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.444 | |
| 2b9y | FAD | Putative aminooxidase | / | 0.444 | |
| 2cdu | ADP | NADH oxidase | / | 0.444 | |
| 2hfu | MEV | Mevalonate kinase | / | 0.444 | |
| 2ahc | VNL | Chorismate pyruvate-lyase | / | 0.443 | |
| 2ylz | FAD | Phenylacetone monooxygenase | 1.14.13.92 | 0.443 | |
| 3cgt | BCD | Cyclomaltodextrin glucanotransferase | 2.4.1.19 | 0.443 | |
| 3lsi | FAD | Pyranose 2-oxidase | / | 0.443 | |
| 2iqg | F2I | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 2iu0 | 203 | Bifunctional purine biosynthesis protein PURH | 2.1.2.3 | 0.442 | |
| 2vn9 | GVD | Calcium/calmodulin-dependent protein kinase type II subunit delta | 2.7.11.17 | 0.442 | |
| 2ylr | NAP | Phenylacetone monooxygenase | 1.14.13.92 | 0.442 | |
| 3cgd | NAD | Coenzyme A disulfide reductase | / | 0.442 | |
| 1ot7 | CHC | Bile acid receptor | / | 0.441 | |
| 2d0o | ADP | Diol dehydratase-reactivating factor alpha subunit | / | 0.441 | |
| 3djj | FAD | Glutathione reductase, mitochondrial | 1.8.1.7 | 0.441 | |
| 4o67 | 1SY | Cyclic GMP-AMP synthase | / | 0.441 | |
| 2eph | ASP_TRP_ASN | Fructose-bisphosphate aldolase | 4.1.2.13 | 0.440 | |
| 2ntr | L00 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 3gbu | ATP | Uncharacterized sugar kinase PH1459 | 2.7.1 | 0.440 | |
| 3h06 | VBP | Glutamate receptor 2 | / | 0.440 | |
| 3nd6 | ATP | Phosphopantetheine adenylyltransferase | / | 0.440 |