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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2eq8FADDihydrolipoyl dehydrogenase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2eq8FADDihydrolipoyl dehydrogenase/1.000
4jq9FADDihydrolipoyl dehydrogenase/0.536
1zk7FADMercuric reductase1.16.1.10.533
1zx9FADMercuric reductase1.16.1.10.526
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.522
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.520
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.514
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.513
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.512
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.511
3ladFADDihydrolipoyl dehydrogenase/0.500
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.498
2r9zFADGlutathione amide reductase/0.489
2yquFADDihydrolipoyl dehydrogenase/0.486
3urhFADDihydrolipoyl dehydrogenase/0.480
1jehFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.471
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.462
3ic9FADPutative dihydrolipoamide dehydrogenase/0.462
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.460
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.457
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.456
1lvlFADDihydrolipoyl dehydrogenase1.8.1.40.449
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.449
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.447
1nhpFADNADH peroxidase1.11.1.10.446
4m52FADDihydrolipoyl dehydrogenase1.8.1.40.444
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.442
3grsFADGlutathione reductase, mitochondrial1.8.1.70.442
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.442
1grhFADGlutathione reductase, mitochondrial1.8.1.70.440