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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2ek3SAHDiphthine synthase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2ek3SAHDiphthine synthase/1.000
2hutSAHDiphthine synthase/0.838
2dv5SAHDiphthine synthase/0.817
2e15SAHDiphthine synthase/0.811
2owkSAHDiphthine synthase/0.792
2eh2SAHDiphthine synthase/0.788
2p6iSAHDiphthine synthase/0.768
2owgSAHDiphthine synthase/0.761
2huqSAHDiphthine synthase/0.760
2owuSAHDiphthine synthase/0.751
2p5cSAHDiphthine synthase/0.749
2p9dSAHDiphthine synthase/0.748
2dsiSAHDiphthine synthase/0.741
2e17SAHDiphthine synthase/0.741
2ek2SAHDiphthine synthase/0.735
2e8rSAHDiphthine synthase/0.734
2dxxSAHDiphthine synthase/0.730
2z6rSAHDiphthine synthase/0.725
2p5fSAHDiphthine synthase/0.723
2pb5SAHDiphthine synthase/0.723
2ed5SAHDiphthine synthase/0.720
2huvSAHDiphthine synthase/0.720
2eh4SAHDiphthine synthase/0.713
2emuSAHDiphthine synthase/0.710
2eleSAHDiphthine synthase/0.709
2eeqSAHDiphthine synthase/0.702
2ehlSAHDiphthine synthase/0.699
2pcaSAHDiphthine synthase/0.699
2pckSAHDiphthine synthase/0.697
2dv7SAHDiphthine synthase/0.692
2e4nSAHDiphthine synthase/0.687
2e7rSAHDiphthine synthase/0.683
2hr8SAHDiphthine synthase/0.679
2eh5SAHDiphthine synthase/0.678
2p2xSAHDiphthine synthase/0.677
2eniSAHDiphthine synthase/0.672
2emrSAHDiphthine synthase/0.667
2e08SAHDiphthine synthase/0.666
2el3SAHDiphthine synthase/0.662
2pb6SAHDiphthine synthase/0.658
1wngSAHDiphthine synthase/0.655
2e07SAHDiphthine synthase/0.653
2el0SAHDiphthine synthase/0.653
2dekSAHDiphthine synthase/0.650
2pcgSAHDiphthine synthase/0.649
1vceSAHDiphthine synthase/0.648
2dshSAHDiphthine synthase/0.647
2dv4SAHDiphthine synthase/0.647
2e8hSAHDiphthine synthase/0.647
2egsSAHDiphthine synthase/0.645
2ejkSAHDiphthine synthase/0.644
2pciSAHDiphthine synthase/0.644
2egbSAHDiphthine synthase/0.641
2dv3SAHDiphthine synthase/0.636
2ejjSAHDiphthine synthase/0.635
2eldSAHDiphthine synthase/0.633
2dxwSAHDiphthine synthase/0.627
2ek4SAHDiphthine synthase/0.626
2pcmSAHDiphthine synthase/0.626
2dsgSAHDiphthine synthase/0.625
2ed3SAHDiphthine synthase/0.625
2p6kSAHDiphthine synthase/0.619
2dxvSAHDiphthine synthase/0.618
2ekaSAHDiphthine synthase/0.618
2p6dSAHDiphthine synthase/0.616
2pchSAHDiphthine synthase/0.606
2p6lSAHDiphthine synthase/0.590
2huxSAHDiphthine synthase/0.589
2owvSAHDiphthine synthase/0.585
2eglSAHDiphthine synthase/0.578
2owfSAHDiphthine synthase/0.578
2e8qSAHDiphthine synthase/0.572
2e16SAHDiphthine synthase/0.571
2en5SAHDiphthine synthase/0.570
2ek7SAHDiphthine synthase/0.559
2e8sSAHDiphthine synthase/0.550
2ejzSAHDiphthine synthase/0.536
2pb4SAHDiphthine synthase/0.529
2clqSTUMitogen-activated protein kinase kinase kinase 52.7.11.250.466
2znnS44Peroxisome proliferator-activated receptor alpha/0.462
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.460
1xe65FPPlasmepsin-23.4.23.390.458
4prvADPDNA gyrase subunit B/0.458
4ktkKTKCytochrome P450/0.457
4jl5ADPAdenylate kinase/0.454
4ktl1CQCytochrome P450/0.454
1pjcNADAlanine dehydrogenase/0.453
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.453
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.453
3up5FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.451
3fwiCAMCamphor 5-monooxygenase1.14.15.10.450
3uozFAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.450
4q71FADBifunctional protein PutA/0.450
2cgv3B3Serine/threonine-protein kinase Chk12.7.11.10.449
3b70NAPEnoyl reductase LovC10.448
2cy0NAPShikimate dehydrogenase (NADP(+))/0.447
4bfxZVXPantothenate kinase2.7.1.330.447
2givACOHistone acetyltransferase KAT8/0.445
2qs3UBEGlutamate receptor ionotropic, kainate 1/0.445
3gw9VNILanosterol 14-alpha-demethylase/0.445
3qt62P0Mevalonate diphosphate decarboxylase/0.445
1bdlIM1Gag-Pol polyprotein3.4.23.160.444
2he5NDPAldo-keto reductase family 1 member C211.1.10.444
2hfuMEVMevalonate kinase/0.444
3ijoB4DGlutamate receptor 2/0.444
1dirNADDihydropteridine reductase1.5.1.340.443
4jloADPAdenylate kinase/0.443
1t86CAMCamphor 5-monooxygenase1.14.15.10.442
1t88CAMCamphor 5-monooxygenase1.14.15.10.442
2wedPP6Penicillopepsin-13.4.23.200.442
3k3ePDBHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.442
4g47TZFMycocyclosin synthase1.14.21.90.442
4z61ILE_THR_GLN_TYS_TYSPhytosulfokine receptor 12.7.11.10.442
1f20FADNitric oxide synthase, brain1.14.13.390.441
1rd7FOLDihydrofolate reductase1.5.1.30.441
3zh8C58Protein kinase C iota type2.7.11.130.441
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.441
1vp6CMPCyclic nucleotide-gated potassium channel mll3241/0.440
4enhFVXCholesterol 24-hydroxylase/0.440