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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
2b7aIZATyrosine-protein kinase JAK2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
2b7aIZATyrosine-protein kinase JAK2/1.000
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.512
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.510
3lxpIZANon-receptor tyrosine-protein kinase TYK22.7.10.20.481
2xa4AZ5Tyrosine-protein kinase JAK2/0.479
3zm422TDual specificity mitogen-activated protein kinase kinase 12.7.12.20.471
4e200MYNon-receptor tyrosine-protein kinase TYK22.7.10.20.470
2xikJ60Serine/threonine-protein kinase 252.7.11.10.464
4k771Q4Tyrosine-protein kinase JAK1/0.461
4qmpDKISerine/threonine-protein kinase 242.7.11.10.461
3iok1P6Tyrosine-protein kinase JAK2/0.460
4e4m0NHTyrosine-protein kinase JAK2/0.458
1qrpHH0Pepsin A-43.4.23.10.456
4u9aSTUInterleukin-1 receptor-associated kinase 42.7.11.10.456
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.453
3il1B5DGlutamate receptor 2/0.450
3zep1NXTyrosine-protein kinase JAK32.7.10.20.450
3eyhIZATyrosine-protein kinase JAK1/0.449
4hge15VTyrosine-protein kinase JAK2/0.448
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.447
4gj30XPNon-receptor tyrosine-protein kinase TYK22.7.10.20.446
3zmmF9JTyrosine-protein kinase JAK2/0.444
1lrjUD1UDP-glucose 4-epimerase5.1.3.20.442
1m2pHNACasein kinase II subunit alpha2.7.11.10.442
3amaSKEcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.442
4c34STUcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
3zlx5EZDual specificity mitogen-activated protein kinase kinase 12.7.12.20.440