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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1xl2189Gag-Pol polyprotein3.4.23.16

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity
Align
1xl2189Gag-Pol polyprotein3.4.23.161.000
3bheBZNGag-Pol polyprotein3.4.23.160.650
3nwxKVSGag-Pol polyprotein3.4.23.160.583
3nwq2NCGag-Pol polyprotein3.4.23.160.559
1c70L75Protease/0.551
1k6tXN1Gag-Pol polyprotein3.4.23.160.550
1k6pXN3Gag-Pol polyprotein3.4.23.160.546
3cktYDPGag-Pol polyprotein3.4.23.160.546
2hs2017Protease/0.545
3em6017Gag-Pol polyprotein3.4.23.160.540
3t113T1Gag-Pol polyprotein3.4.23.160.539
3ekqROCGag-Pol polyprotein3.4.23.160.531
2aidTHKGag-Pol polyprotein3.4.23.160.529
1k6cMK1Gag-Pol polyprotein3.4.23.160.528
2pqzG0GGag-Pol polyprotein3.4.23.160.528
1hihC20Gag-Pol polyprotein/0.525
2q54MU1Protease/0.525
2qhcAB1Protease/0.524
1b6mPI6Gag-Pol polyprotein3.4.23.160.518
3ggaGGWGag-Pol polyprotein/0.517
3nxe2NCProtease/0.517
2r43G3GGag-Pol polyprotein3.4.23.160.516
1hiiC20Gag-Pol polyprotein/0.515
3aidARQGag-Pol polyprotein3.4.23.160.515
2r3wG3GGag-Pol polyprotein3.4.23.160.514
3qroNK9Gag-Pol polyprotein3.4.23.160.513
2r38G4GGag-Pol polyprotein3.4.23.160.512
3dcrKVSProtease/0.512
3kfs3TLGag-Pol polyprotein/0.511
1z1hHBBGag-Pol polyprotein3.4.23.160.510
3el01UNGag-Pol polyprotein3.4.23.160.510
3lzv017Gag-Pol polyprotein3.4.23.160.510
3pwrROCGag-Pol polyprotein3.4.23.160.510
1hvlA76Gag-Pol polyprotein/0.509
2f3kRO1Protease/0.509
3qbfJHGGag-Pol polyprotein3.4.23.160.509
1hviA77Protease/0.508
3bxsDRSGag-Pol polyprotein3.4.23.160.508
1xl5190Gag-Pol polyprotein3.4.23.160.507
2qnqQN3Gag-Pol polyprotein3.4.23.160.505
1a940Q4Gag-Pol polyprotein3.4.23.160.503
1difA85Gag-Pol polyprotein/0.503
1hvhQ82Gag-Pol polyprotein3.4.23.160.503
2a4fAAUV-1 protease/0.503
2pym1UNGag-Pol polyprotein3.4.23.160.503
3oxcROCProtease/0.503
3s85LK0Gag-Pol polyprotein/0.503
1k6vXN2Gag-Pol polyprotein3.4.23.160.502
2q641UNGag-Pol polyprotein3.4.23.160.502
3d1xROCGag-Pol polyprotein3.4.23.160.502
3ekx1UNGag-Pol polyprotein3.4.23.160.502
1w5vBE3Gag-Pol polyprotein3.4.23.160.501
2hc0AB2Protease/0.501
3el51UNGag-Pol polyprotein/0.501
1a8g2Z4Gag-Pol polyprotein3.4.23.160.500
1ivp1ZKGag-Pol polyprotein/0.500
2nmyROCProtease/0.500
3ggxGGXGag-Pol polyprotein/0.500
1c6x3INProtease/0.499
1hvjA78Gag-Pol polyprotein/0.499
1sduMK1Gag-Pol polyprotein3.4.23.160.498
2qnnQN1Gag-Pol polyprotein3.4.23.160.498
3nduROCGag-Pol polyprotein3.4.23.160.498
3qihFG7Gag-Pol polyprotein3.4.23.160.498
1hvsA77Gag-Pol polyprotein/0.497
1mtrPI6Gag-Pol polyprotein3.4.23.160.497
3qrmNK7Gag-Pol polyprotein3.4.23.160.497
2b7zMK1Gag-Pol polyprotein/0.496
2bqvA1AProtease/0.496
4djqM86Pol polyprotein/0.496
1wbmBLLPol protein/0.495
2r3tG4GGag-Pol polyprotein3.4.23.160.495
1hsgMK1Gag-Pol polyprotein/0.494
2qi3MZ5Gag-Pol polyprotein/0.494
2r5q1UNGag-Pol polyprotein/0.494
1d4lPI9Gag-Pol polyprotein3.4.23.160.493
1jld0PPGag-Pol polyprotein/0.493
1sdvMK1Gag-Pol polyprotein3.4.23.160.493
2xyeCXGGag-Pol polyprotein/0.493
2xyfG40Gag-Pol polyprotein/0.493
3el4ROCGag-Pol polyprotein3.4.23.160.493
1ec3MS3Gag-Pol polyprotein3.4.23.160.492
2pwcG3GGag-Pol polyprotein3.4.23.160.492
4njt017Protease/0.492
1hshMK1Gag-Pol polyprotein/0.491
1ivq0PXGag-Pol polyprotein/0.491
2qd8065Gag-Pol polyprotein3.4.23.160.491
3d1yROCGag-Pol polyprotein3.4.23.160.491
3i6oGR6Gag-Pol polyprotein3.4.23.160.491
3s54017Protease/0.491
3kf03TLGag-Pol polyprotein/0.490
1ec0BEDGag-Pol polyprotein3.4.23.160.489
1hosPHPGag-Pol polyprotein/0.489
2aquDR7Gag-Pol polyprotein3.4.23.160.489
3qpjN4IGag-Pol polyprotein3.4.23.160.489
1d4kPI8Gag-Pol polyprotein3.4.23.160.488
1ohr1UNV-1 PROTEASE protein/0.488
3cyxROCGag-Pol polyprotein3.4.23.160.488
3nu9478Gag-Pol polyprotein3.4.23.160.488
1bai0Q4Gag-Pro polyprotein/0.487
1sdtMK1Gag-Pol polyprotein3.4.23.160.487
1vikBAYGag-Pol polyprotein/0.487
1zsr0ZTGag-Pol polyprotein3.4.23.160.487
2bpy3INGag-Pol polyprotein3.4.23.160.487
2bpz3INGag-Pol polyprotein3.4.23.160.487
2nnkROCProtease/0.487
2qhyMZ1Gag-Pol polyprotein/0.487
3gi6D78Gag-Pol polyprotein/0.487
1c6zROCProtease/0.486
1k1u0Q4Gag-Pol polyprotein3.4.23.160.486
1wbk568Pol protein/0.486
2bpv1INGag-Pol polyprotein3.4.23.160.486
2p3b3TLV-1 PROTEASE protein/0.486
2p3b3TLV-1 protease/0.486
2pyn1UNGag-Pol polyprotein3.4.23.160.486
3i7eDJRGag-Pol polyprotein/0.486
3ndxRITGag-Pol polyprotein3.4.23.160.486
3qihNI7Gag-Pol polyprotein3.4.23.160.486
3qn8NI7Gag-Pol polyprotein3.4.23.160.486
1b6kPI5Gag-Pol polyprotein3.4.23.160.485
1ebzBECGag-Pol polyprotein3.4.23.160.485
1npa3NHGag-Pol polyprotein3.4.23.160.485
1npwLGZGag-Pol polyprotein3.4.23.160.485
2bpxMK1Gag-Pol polyprotein3.4.23.160.485
2fdd385Pol protein/0.485
2qak1UNGag-Pol polyprotein3.4.23.160.485
3ttp017Gag-Pol polyprotein3.4.23.160.485
4dqf017Gag-Pol polyprotein/0.485
1t7kBH0Gag-Pol polyprotein3.4.23.160.484
2avvMK1Gag-Pol polyprotein3.4.23.160.484
2hs1017Protease/0.484
2q5kAB1Protease/0.484
2qi0MZ3Gag-Pol polyprotein/0.484
3jvwDMPGag-Pol polyprotein3.4.23.160.484
3qp0NI8Gag-Pol polyprotein3.4.23.160.484
1hxbROCGag-Pol polyprotein3.4.23.160.483
1izhQ50Protease/0.483
2bb9AKCGag-Pol polyprotein3.4.23.160.483
2fxdDR7Pol polyprotein/0.483
2wl05AHGag-Pol polyprotein/0.483
3kfn3TLGag-Pol polyprotein/0.483
3nu5478Gag-Pol polyprotein3.4.23.160.483
3o99K13Pol polyprotein/0.483
3sa9A68Protease/0.483
3vf7031Gag-Pol polyprotein3.4.23.160.483
1a8k0Q4Gag-Pol polyprotein3.4.23.160.482
1ajxAH1Gag-Pol polyprotein3.4.23.160.482
1kzkJE2Gag-Pol polyprotein3.4.23.160.482
2wkz5AHGag-Pol polyprotein/0.482
3lixE17Protease/0.482
3oxxDR7Gag-Pol polyprotein3.4.23.160.482
1meuDMPGag-Pol polyprotein3.4.23.160.481
2qnpQN2Gag-Pol polyprotein3.4.23.160.481
3kfr3TLGag-Pol polyprotein/0.481
3mws017Pol protein/0.481
3nu6478Gag-Pol polyprotein3.4.23.160.481
3o9cK20Pol polyprotein/0.481
3qrsNK8Gag-Pol polyprotein3.4.23.160.481
1ec2BEJGag-Pol polyprotein3.4.23.160.480
2cej1AHPol protein/0.480
3ekv478Gag-Pol polyprotein3.4.23.160.480
3jvy017Gag-Pol polyprotein3.4.23.160.480
4dqc017Gag-Pol polyprotein/0.480
4q1y017Gag-Pol polyprotein3.4.23.160.480
1a9mU0EGag-Pol polyprotein/0.479
1hvrXK2Gag-Pol polyprotein/0.479
1sguMK1Gag-Pol polyprotein3.4.23.160.479
3djkG55Gag-Pol polyprotein3.4.23.160.479
3hzc2NCProtease/0.479
3st5G89Gag-Pol polyprotein3.4.23.160.479
1b6pPI7Gag-Pol polyprotein3.4.23.160.478
1c6yMK1Protease/0.477
1muiAB1Protease/0.477
2i4dQFIProtease/0.477
2i4xKGQProtease/0.477
2q3kMUWGag-Pol polyprotein/0.477
1b6lPI4Gag-Pol polyprotein3.4.23.160.476
1ebwBEIGag-Pol polyprotein3.4.23.160.476
1tcxIM1Gag-Pol polyprotein3.4.23.160.476
1z1rHBHGag-Pol polyprotein3.4.23.160.476
2bpw1INGag-Pol polyprotein3.4.23.160.476
2f80017Gag-Pol polyprotein3.4.23.160.476
3nuo478Gag-Pol polyprotein3.4.23.160.476
3o9iA61Gag-Pol polyprotein/0.476
1bdrIM1Gag-Pol polyprotein3.4.23.160.475
2f8g017Gag-Pol polyprotein3.4.23.160.475
2q631UNGag-Pol polyprotein3.4.23.160.475
2z54AB1Gag-Pol polyprotein3.4.23.160.475
3ekyDR7Gag-Pol polyprotein3.4.23.160.475
3linE13Protease/0.475
3tl9ROCGag-Pol polyprotein3.4.23.160.475
1odw0E8Gag-Pol polyprotein3.4.23.160.474
1rl8RITGag-Pol polyprotein3.4.23.160.474
1sbgIM1Gag-Pol polyprotein/0.474
1zsf0ZSGag-Pol polyprotein3.4.23.160.474
2nnpROCProtease/0.474
2r5pMK1Gag-Pol polyprotein/0.474
3bgbLJGGag-Pol polyprotein3.4.23.160.474
3oxw017Gag-Pol polyprotein3.4.23.160.474
3pwm017Gag-Pol polyprotein3.4.23.160.474
3vfb031Gag-Pol polyprotein3.4.23.160.474
4dqe017Gag-Pol polyprotein/0.474
1daz0Q4Gag-Pol polyprotein3.4.23.160.473
1iziQ50Gag-Pol polyprotein3.4.23.160.473
3bgcLJHGag-Pol polyprotein3.4.23.160.473
3gi4K60Gag-Pol polyprotein/0.473
3sa323XProtease/0.473
4djoMK5Pol polyprotein/0.473
4njsG08Protease/0.473
1d4yTPVGag-Pol polyprotein3.4.23.160.472
1hpxKNIGag-Pol polyprotein/0.472
2hb3GRLProtease/0.472
2qd7065Gag-Pol polyprotein3.4.23.160.472
3s43478Protease/0.472
3s56ROCProtease/0.472
3sa5A69Protease/0.472
1hpv478Gag-Pol polyprotein/0.471
1ida0POGag-Pol polyprotein3.4.23.470.471
1vijBAYGag-Pol polyprotein/0.471
2qhzMZ2Gag-Pol polyprotein/0.471
2rkfAB1Pol protein/0.471
2uy0HV1Gag-Pol polyprotein3.4.23.160.471
3ndwRITGag-Pol polyprotein3.4.23.160.471
3nu3478Gag-Pol polyprotein3.4.23.160.471
3o9gF53Gag-Pol polyprotein/0.471
3oxv478Gag-Pol polyprotein3.4.23.160.471
1d4iBEGGag-Pol polyprotein3.4.23.160.470
1hbvGANGag-Pol polyprotein/0.470
1hxwRITGag-Pol polyprotein/0.470
2cen4AHProtease/0.470
2i4uDJRProtease/0.470
2pwrG4GGag-Pol polyprotein3.4.23.160.470
2qi5MZ7Gag-Pol polyprotein/0.470
3el1DR7Gag-Pol polyprotein3.4.23.160.470
3ggu017Gag-Pol polyprotein3.4.23.160.470
3nuj478Gag-Pol polyprotein3.4.23.160.470
3sa6F71Protease/0.470
3saa77FProtease/0.470
4hdfG52Gag-Pol polyprotein3.4.23.160.470
4qgiROCGag-Pol polyprotein3.4.23.160.470
1hiv1ZKGag-Pol polyprotein/0.469
1m0b0ZQGag-Pol polyprotein3.4.23.160.469
1mrwK57Gag-Pol polyprotein3.4.23.160.469
1qbu846Gag-Pol polyprotein3.4.23.160.469
3k4vROCGag-Pol polyprotein3.4.23.160.469
3ogqAB1Pol polyprotein/0.469
3vfa031Gag-Pol polyprotein3.4.23.160.469
1ebyBEBGag-Pol polyprotein3.4.23.160.468
1idb0DOGag-Pol polyprotein/0.468
1proA88Gag-Pol polyprotein/0.468
2fleAIProtease/0.468
2p3d3TLProtease/0.468
3d20017Gag-Pol polyprotein3.4.23.160.468
1merDMQGag-Pol polyprotein3.4.23.160.467
1qbt146Gag-Pol polyprotein3.4.23.160.467
2avsMK1Gag-Pol polyprotein3.4.23.160.467
2z4o065Gag-Pol polyprotein3.4.23.160.467
3ekwDR7Gag-Pol polyprotein3.4.23.160.467
3el9DR7Gag-Pol polyprotein3.4.23.160.467
3livE16Protease/0.467
3vf5031Gag-Pol polyprotein3.4.23.160.467
1w5yBE6Gag-Pol polyprotein3.4.23.160.466
2b60RITPol polyprotein/0.466
3kddJZQGag-Pol polyprotein3.4.23.160.466
3o9dK19Pol polyprotein/0.466
3qaaG04Gag-Pol polyprotein3.4.23.160.466
3zptM8YGag-Pol polyprotein3.4.23.160.466
1g35AHFGag-Pol polyprotein3.4.23.160.465
1w5xBE5Gag-Pol polyprotein3.4.23.160.465
2fde385Gag-Pol polyprotein3.4.23.160.465
3nu4478Gag-Pol polyprotein3.4.23.160.465
1fej2NCGag-Pol polyprotein3.4.23.160.464
1mesDMPGag-Pol polyprotein3.4.23.160.464
1t7j478Gag-Pol polyprotein3.4.23.160.464
2cem2AHPol protein/0.464
2i4wKGQProtease/0.464
2idw017Protease/0.464
2qi1MZ4Gag-Pol polyprotein/0.464
3o9aK14Pol polyprotein/0.464
3tog079Gag-Pol polyprotein2.7.7.490.464
4hla017Gag-Pol polyprotein3.4.23.160.464
1bwaXV6Gag-Pol polyprotein3.4.23.160.463
1qbrXV6Gag-Pol polyprotein3.4.23.160.463
2avm2NCGag-Pol polyprotein3.4.23.160.463
2qi4MZ6Gag-Pol polyprotein/0.463
3mxdK53Gag-Pol polyprotein3.4.23.160.463
4djpM73Pol polyprotein/0.463
4dqb017Gag-Pol polyprotein/0.463
1dmpDMQGag-Pol polyprotein3.4.23.160.462
2pk6O33V-1 protease/0.462
3em3478Gag-Pol polyprotein3.4.23.160.462
3sa755AProtease/0.462
4dqh017Gag-Pol polyprotein/0.462
4njvRITProtease/0.462
4rvj478Protease/0.462
1d4hBEHGag-Pol polyprotein3.4.23.160.461
1qbsDMPGag-Pol polyprotein3.4.23.160.461
1t7i017Gag-Pol polyprotein3.4.23.160.461
2qci065Gag-Pol polyprotein3.4.23.160.461
2qd6065Gag-Pol polyprotein3.4.23.160.461
3ndtROCGag-Pol polyprotein3.4.23.160.461
3oy4017Gag-Pol polyprotein3.4.23.160.461
3t3c017Gag-Pol polyprotein3.4.23.160.461
3zpsEQMGag-Pol polyprotein3.4.23.160.461
4j5j478Gag-Pol polyprotein3.4.23.160.461
2i4vDJRV-1 protease/0.460
2p3a3TLPol protein/0.460
3d1z017Gag-Pol polyprotein3.4.23.160.460
3o9hK2EGag-Pol polyprotein/0.460
4k4p3TLGag-Pol polyprotein/0.460
1fgc2NCGag-Pol polyprotein3.4.23.160.459
3a2oKNJGag-Pol polyprotein3.4.23.160.459
3bxrDRRGag-Pol polyprotein3.4.23.160.459
3zpuM8BGag-Pol polyprotein3.4.23.160.459
4dfg0JVGag-Pol polyprotein3.4.23.160.459
4hegG52Gag-Pol polyprotein3.4.23.160.459
1bwb146Gag-Pol polyprotein3.4.23.160.458
1fg80Q4Gag-Pol polyprotein3.4.23.160.458
1yt9OISGag-Pol polyprotein/0.458
2fxeDR7Gag-Pol polyprotein3.4.23.160.458
2qi7MZ9Gag-Pol polyprotein/0.458
3toh079Gag-Pol polyprotein2.7.7.490.458
4j55031Gag-Pol polyprotein3.4.23.160.458
1hvkA79Gag-Pol polyprotein/0.457
4gb20LQGag-Pol polyprotein2.7.7.490.457
1hwr216Gag-Pol polyprotein3.4.23.160.456
2q55MU0Protease/0.456
3cyw017Gag-Pol polyprotein3.4.23.160.456
3i2l2NCProtease/0.456
3jw2017Gag-Pol polyprotein3.4.23.160.456
3tof076Gag-Pol polyprotein2.7.7.490.456
4ye3G04Gag-Pol polyprotein3.4.23.160.456
2aoe0Q4Gag-Pol polyprotein3.4.23.160.455
2ieo017Protease/0.455
2psvMUVProtease/0.455
3nyg2NCGag-Pol polyprotein3.4.23.160.455
3o9eA60Pol polyprotein/0.455
1fg62NCGag-Pol polyprotein3.4.23.160.454
1npvL27Gag-Pol polyprotein3.4.23.160.454
1sh9RITGag-Pol polyprotein3.4.23.160.454
3ekt017Gag-Pol polyprotein3.4.23.160.454
3em4DR7Gag-Pol polyprotein3.4.23.160.454
3mxeK54Gag-Pol polyprotein3.4.23.160.454
4djr0KJPol polyprotein/0.454
1iiq0ZRGag-Pol polyprotein3.4.23.160.453
1k2c0Q4Gag-Pol polyprotein3.4.23.160.453
3r4b74TGag-Pol polyprotein/0.453
4a6bQG8Gag-Pol polyprotein3.4.23.160.453
1d4jMSCGag-Pol polyprotein3.4.23.160.452
1ff02NCGag-Pol polyprotein3.4.23.160.452
1k2b0Q4Gag-Pol polyprotein3.4.23.160.452
4i8zG08Gag-Pol polyprotein3.4.23.160.452
1bdlIM1Gag-Pol polyprotein3.4.23.160.451
1metDMPGag-Pol polyprotein3.4.23.160.451
3o9fK2DGag-Pol polyprotein/0.451
1dw60Q4Gag-Pol polyprotein3.4.23.160.450
1ec1BEEGag-Pol polyprotein3.4.23.160.450
1g2kNM1Gag-Pol polyprotein3.4.23.160.450
1msmJE2Gag-Pol polyprotein3.4.23.160.450
1msnJE2Gag-Pol polyprotein3.4.23.160.450
2p3c3TLProtease/0.450
4a6cQG9Gag-Pol polyprotein3.4.23.160.450
4kb9G79Protease/0.450
4q1w017Gag-Pol polyprotein3.4.23.160.450
2ien017Gag-Pol polyprotein3.4.23.160.449
2qi6MZ8Gag-Pol polyprotein/0.449
1ffi2NCGag-Pol polyprotein3.4.23.160.448
1hpoUNIGag-Pol polyprotein3.4.23.160.448
2f81017Gag-Pol polyprotein3.4.23.160.448
3liqE14Protease/0.448
1bv7XV6Gag-Pol polyprotein3.4.23.160.447
1odyLP1Gag-Pol polyprotein3.4.23.160.447
3kdcJZPGag-Pol polyprotein3.4.23.160.447
2bbbHH1Gag-Pol polyprotein3.4.23.160.446
2psuMUUProtease/0.446
1fff0Q4Gag-Pol polyprotein3.4.23.160.445
3ekp478Gag-Pol polyprotein3.4.23.160.445
3sa4F72Protease/0.445
4a4qUX9Pol protein/0.445
4q1x017Gag-Pol polyprotein3.4.23.160.445
1t3r017Gag-Pol polyprotein3.4.23.160.444
2pk5075Protease/0.444
3bvb017Gag-Pol polyprotein3.4.23.160.444
3ok9G52Gag-Pol polyprotein3.4.23.160.444
3wsjMK1Protease/0.444
9hvp0E9Gag-Pol polyprotein/0.444
2uxzHI1Gag-Pol polyprotein3.4.23.160.443
3fx5KNIGag-Pol polyprotein3.4.23.160.443
3g70A5TRenin3.4.23.150.443
3lzu017Gag-Pol polyprotein3.4.23.160.443
3uhl2NCGag-Pol polyprotein3.4.23.160.443
3upjU03Gag-Pol polyprotein/0.442
7upjINUGag-Pol polyprotein3.4.23.160.442
3o9bK2APol polyprotein/0.441
3sa8K83Protease/0.441
3dk1G05Gag-Pol polyprotein3.4.23.160.440
3lzs017Gag-Pol polyprotein3.4.23.160.440