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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1typFADTrypanothione reductase1.8.1.12

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1typFADTrypanothione reductase1.8.1.121.000
1feaFADTrypanothione reductase1.8.1.120.595
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.584
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.578
1greFADGlutathione reductase, mitochondrial1.8.1.70.577
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.573
4dnaFADProbable glutathione reductase/0.573
1h6vFADThioredoxin reductase 1, cytoplasmic1.8.1.90.571
3qfbFADThioredoxin reductase 1, cytoplasmic1.8.1.90.571
1febFADTrypanothione reductase1.8.1.120.569
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.564
3dk8FADGlutathione reductase, mitochondrial1.8.1.70.562
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.556
2wbaFADTrypanothione reductase1.8.1.120.556
1grhFADGlutathione reductase, mitochondrial1.8.1.70.554
2v6oFADThioredoxin glutathione reductase/0.553
1grgFADGlutathione reductase, mitochondrial1.8.1.70.552
3dgzFADThioredoxin reductase 2, mitochondrial1.8.1.90.552
1graFADGlutathione reductase, mitochondrial1.8.1.70.549
3dk4FADGlutathione reductase, mitochondrial1.8.1.70.549
4kprFADThioredoxin reductase 1, cytoplasmic1.8.1.90.548
1gerFADGlutathione reductase1.8.1.70.547
3dk9FADGlutathione reductase, mitochondrial1.8.1.70.545
1bzlFADTrypanothione reductase1.8.1.120.540
3grsFADGlutathione reductase, mitochondrial1.8.1.70.535
4j56FADThioredoxin reductase 21.8.1.90.535
4nevFADTrypanothione reductase/0.534
3eanFADThioredoxin reductase 1, cytoplasmic1.8.1.90.530
1bwcFADGlutathione reductase, mitochondrial1.8.1.70.523
1ebdFADDihydrolipoyl dehydrogenase1.8.1.40.521
1gxfFADTrypanothione reductase1.8.1.120.521
1gsnFADGlutathione reductase, mitochondrial1.8.1.70.519
1lvlFADDihydrolipoyl dehydrogenase1.8.1.40.519
2wp5FADTrypanothione reductase/0.511
2wowFADTrypanothione reductase/0.504
2r9zFADGlutathione amide reductase/0.503
2w0hFADTrypanothione reductase/0.503
1onfFADGlutathione reductase1.8.1.70.488
4j57FADThioredoxin reductase 21.8.1.90.476
2eq8FADDihydrolipoyl dehydrogenase/0.475
4jq9FADDihydrolipoyl dehydrogenase/0.472
4emwFADCoenzyme A disulfide reductase/0.471
1jehFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.460
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.453
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.453
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.451
2eq9FADDihydrolipoyl dehydrogenase/0.448
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.448
1v59FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.446
4em4FADCoenzyme A disulfide reductase/0.446
4a6cQG9Gag-Pol polyprotein3.4.23.160.445
1zx9FADMercuric reductase1.16.1.10.444
4m52FADDihydrolipoyl dehydrogenase1.8.1.40.441