sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1sb1 | 165 | Prothrombin | 3.4.21.5 |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1sb1 | 165 | Prothrombin | 3.4.21.5 | 1.000 | |
| 2jh5 | 895 | Prothrombin | 3.4.21.5 | 0.687 | |
| 1ypk | CCR | Prothrombin | 3.4.21.5 | 0.685 | |
| 1ypm | RA4 | Prothrombin | 3.4.21.5 | 0.676 | |
| 1d6w | 00R | Prothrombin | 3.4.21.5 | 0.664 | |
| 1ypl | RA8 | Prothrombin | 3.4.21.5 | 0.650 | |
| 1oyt | FSN | Prothrombin | 3.4.21.5 | 0.643 | |
| 1ypj | UIB | Prothrombin | 3.4.21.5 | 0.634 | |
| 2zc9 | 22U | Prothrombin | 3.4.21.5 | 0.630 | |
| 2jh0 | 701 | Prothrombin | 3.4.21.5 | 0.628 | |
| 1ghv | 120 | Prothrombin | 3.4.21.5 | 0.624 | |
| 1d3d | BZT | Prothrombin | 3.4.21.5 | 0.623 | |
| 2v3o | I26 | Prothrombin | 3.4.21.5 | 0.623 | |
| 2jh6 | 894 | Prothrombin | 3.4.21.5 | 0.622 | |
| 2zhq | 27U | Prothrombin | 3.4.21.5 | 0.621 | |
| 2zhf | 49U | Prothrombin | 3.4.21.5 | 0.620 | |
| 2zi2 | 24U | Prothrombin | 3.4.21.5 | 0.619 | |
| 3c1k | T15 | Prothrombin | 3.4.21.5 | 0.618 | |
| 4lxb | 7R9 | Prothrombin | 3.4.21.5 | 0.618 | |
| 3eq0 | 2TS | Prothrombin | 3.4.21.5 | 0.617 | |
| 4n3l | 2FN | Prothrombin | 3.4.21.5 | 0.617 | |
| 1xm1 | GAH | Prothrombin | 3.4.21.5 | 0.616 | |
| 2zfq | 45U | Prothrombin | 3.4.21.5 | 0.616 | |
| 2zfr | 46U | Prothrombin | 3.4.21.5 | 0.616 | |
| 2zda | 32U | Prothrombin | 3.4.21.5 | 0.615 | |
| 1d9i | 00P | Prothrombin | 3.4.21.5 | 0.612 | |
| 1mu6 | CDA | Prothrombin | 3.4.21.5 | 0.612 | |
| 1o2g | 696 | Prothrombin | 3.4.21.5 | 0.611 | |
| 1t4v | 14A | Prothrombin | 3.4.21.5 | 0.611 | |
| 4az2 | 9MU | Prothrombin | 3.4.21.5 | 0.611 | |
| 1bcu | PRL | Prothrombin | 3.4.21.5 | 0.610 | |
| 2cf9 | 348 | Prothrombin | 3.4.21.5 | 0.610 | |
| 1ypg | UIR | Prothrombin | 3.4.21.5 | 0.608 | |
| 3hat | GLY_VAL_ARG_RNG | Prothrombin | 3.4.21.5 | 0.608 | |
| 1z71 | L17 | Prothrombin | 3.4.21.5 | 0.607 | |
| 1t4u | 81A | Prothrombin | 3.4.21.5 | 0.606 | |
| 2znk | 31U | Prothrombin | 3.4.21.5 | 0.606 | |
| 2bvs | 2CE | Prothrombin | 3.4.21.5 | 0.605 | |
| 2uuk | 897 | Prothrombin | 3.4.21.5 | 0.605 | |
| 1ae8 | AZL | Prothrombin | 3.4.21.5 | 0.603 | |
| 1mue | CDD | Prothrombin | 3.4.21.5 | 0.603 | |
| 3qwc | 98P | Prothrombin | 3.4.21.5 | 0.603 | |
| 1o5g | CR9 | Prothrombin | 3.4.21.5 | 0.602 | |
| 2cf8 | ESH | Prothrombin | 3.4.21.5 | 0.601 | |
| 1gj5 | 130 | Prothrombin | 3.4.21.5 | 0.600 | |
| 4ax9 | N5N | Prothrombin | 3.4.21.5 | 0.600 | |
| 2cn0 | F25 | Prothrombin | 3.4.21.5 | 0.598 | |
| 4ayy | 9MX | Prothrombin | 3.4.21.5 | 0.598 | |
| 1k22 | MEL | Prothrombin | 3.4.21.5 | 0.597 | |
| 1uma | IN2 | Prothrombin | 3.4.21.5 | 0.597 | |
| 1nzq | 162 | Prothrombin | 3.4.21.5 | 0.596 | |
| 1ta6 | 177 | Prothrombin | 3.4.21.5 | 0.596 | |
| 1zgi | 382 | Prothrombin | 3.4.21.5 | 0.596 | |
| 3biu | 10U | Prothrombin | 3.4.21.5 | 0.596 | |
| 1nm6 | L86 | Prothrombin | 3.4.21.5 | 0.595 | |
| 2bdy | UNB | Prothrombin | 3.4.21.5 | 0.593 | |
| 4rn6 | 15U | Prothrombin | 3.4.21.5 | 0.593 | |
| 1c4y | IH3 | Prothrombin | 3.4.21.5 | 0.591 | |
| 2r2m | I50 | Prothrombin | 3.4.21.5 | 0.591 | |
| 2zgb | 21U | Prothrombin | 3.4.21.5 | 0.591 | |
| 2zhe | 13U | Prothrombin | 3.4.21.5 | 0.591 | |
| 2zgx | 29U | Prothrombin | 3.4.21.5 | 0.590 | |
| 1d3p | BT3 | Prothrombin | 3.4.21.5 | 0.587 | |
| 1k21 | IGN | Prothrombin | 3.4.21.5 | 0.587 | |
| 2zhw | 12U | Prothrombin | 3.4.21.5 | 0.587 | |
| 3dux | 64U | Prothrombin | 3.4.21.5 | 0.587 | |
| 7kme | ACE_0BN_CHG_PRR | Prothrombin | 3.4.21.5 | 0.587 | |
| 2zff | 53U | Prothrombin | 3.4.21.5 | 0.585 | |
| 2uuj | 896 | Prothrombin | 3.4.21.5 | 0.583 | |
| 2zf0 | 51U | Prothrombin | 3.4.21.5 | 0.582 | |
| 1afe | ALZ | Prothrombin | 3.4.21.5 | 0.581 | |
| 2zdv | 37U | Prothrombin | 3.4.21.5 | 0.580 | |
| 1d4p | BPP | Prothrombin | 3.4.21.5 | 0.578 | |
| 2zg0 | 50U | Prothrombin | 3.4.21.5 | 0.578 | |
| 1a4w | QWE | Prothrombin | 3.4.21.5 | 0.576 | |
| 1jwt | BLI | Prothrombin | 3.4.21.5 | 0.576 | |
| 2pks | G44 | Prothrombin | 3.4.21.5 | 0.576 | |
| 1zrb | 062 | Prothrombin | 3.4.21.5 | 0.575 | |
| 2anm | CDO | Prothrombin | 3.4.21.5 | 0.573 | |
| 4bam | MM9 | Prothrombin | 3.4.21.5 | 0.572 | |
| 1ype | UIP | Prothrombin | 3.4.21.5 | 0.570 | |
| 2v3h | I25 | Prothrombin | 3.4.21.5 | 0.570 | |
| 1zgv | 501 | Prothrombin | 3.4.21.5 | 0.567 | |
| 4ayv | 9MQ | Prothrombin | 3.4.21.5 | 0.560 | |
| 3p17 | 99P | Prothrombin | 3.4.21.5 | 0.558 | |
| 2zfp | 19U | Prothrombin | 3.4.21.5 | 0.557 | |
| 1c4u | IH1 | Prothrombin | 3.4.21.5 | 0.555 | |
| 4e7r | 0NW | Prothrombin | 3.4.21.5 | 0.554 | |
| 1vzq | SHY | Prothrombin | 3.4.21.5 | 0.553 | |
| 4bah | MEL | Prothrombin | 3.4.21.5 | 0.553 | |
| 3dhk | 23U | Prothrombin | 3.4.21.5 | 0.552 | |
| 4bak | M67 | Prothrombin | 3.4.21.5 | 0.552 | |
| 1riw | OSC | Prothrombin | 3.4.21.5 | 0.544 | |
| 3qto | 10P | Prothrombin | 3.4.21.5 | 0.544 | |
| 4bao | MVF | Prothrombin | 3.4.21.5 | 0.539 | |
| 1w7g | MIU | Prothrombin | 3.4.21.5 | 0.537 | |
| 3qtv | 06P | Prothrombin | 3.4.21.5 | 0.532 | |
| 1c1u | BAI | Prothrombin | 3.4.21.5 | 0.529 | |
| 1gj4 | 132 | Prothrombin | 3.4.21.5 | 0.524 | |
| 4ban | M6S | Prothrombin | 3.4.21.5 | 0.524 | |
| 4baq | M4Z | Prothrombin | 3.4.21.5 | 0.523 | |
| 2ziq | 26U | Prothrombin | 3.4.21.5 | 0.521 | |
| 3c27 | DKK | Prothrombin | 3.4.21.5 | 0.518 | |
| 1c4v | IH2 | Prothrombin | 3.4.21.5 | 0.515 | |
| 1uvs | I11 | Prothrombin | 3.4.21.5 | 0.512 | |
| 1mu8 | CDB | Prothrombin | 3.4.21.5 | 0.505 | |
| 5cmx | 0G6 | Prothrombin | 3.4.21.5 | 0.505 | |
| 1c1w | BAH | Prothrombin | 3.4.21.5 | 0.504 | |
| 3biv | 11U | Prothrombin | 3.4.21.5 | 0.497 | |
| 3qdz | PRO_ALA_PRO_ARG | Prothrombin | 3.4.21.5 | 0.495 | |
| 2bxt | C2D | Prothrombin | 3.4.21.5 | 0.494 | |
| 3egk | M18 | Prothrombin | 3.4.21.5 | 0.492 | |
| 4hfp | 15U | Prothrombin | 3.4.21.5 | 0.492 | |
| 1o0d | 163 | Prothrombin | 3.4.21.5 | 0.490 | |
| 3utu | 1TS | Prothrombin | 3.4.21.5 | 0.490 | |
| 1c5n | ESI | Prothrombin | 3.4.21.5 | 0.480 | |
| 1ta2 | 176 | Prothrombin | 3.4.21.5 | 0.468 | |
| 1x1c | SAH | C-20 methyltransferase | / | 0.464 | |
| 4bby | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.464 | |
| 4kby | C2E | Stimulator of interferon genes protein | / | 0.463 | |
| 1ny2 | ARG_PRO_PRO_GLY | Prothrombin | 3.4.21.5 | 0.460 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.454 | |
| 3toz | NAD | Shikimate dehydrogenase (NADP(+)) | / | 0.452 | |
| 4h6p | FMN | Chromate reductase | / | 0.452 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.452 | |
| 2i65 | NAD | ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 | 3.2.2.6 | 0.451 | |
| 3vil | SA0 | Beta-glucosidase | / | 0.450 | |
| 4a80 | 2AN | Major pollen allergen Bet v 1-A | / | 0.450 | |
| 4loy | 6XS | Prothrombin | 3.4.21.5 | 0.450 | |
| 1sa5 | BMV | Protein farnesyltransferase subunit beta | 2.5.1.58 | 0.449 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 1qoq | IGP | Tryptophan synthase alpha chain | / | 0.446 | |
| 4dpi | 0N1 | Beta-secretase 1 | 3.4.23.46 | 0.444 | |
| 3ozd | 4CT | S-methyl-5'-thioadenosine phosphorylase | / | 0.443 | |
| 1x8l | OXR | Retinol dehydratase | / | 0.442 | |
| 2gde | SN3 | Prothrombin | 3.4.21.5 | 0.442 | |
| 2gs9 | SAH | Uncharacterized protein | / | 0.442 | |
| 2iko | 7IG | Renin | 3.4.23.15 | 0.442 | |
| 1fml | RTL | Retinol dehydratase | / | 0.441 | |
| 1kbq | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 3f68 | 91U | Prothrombin | 3.4.21.5 | 0.441 | |
| 3gnc | QQQ | Glutaryl-CoA dehydrogenase | / | 0.441 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.441 | |
| 4b1j | A1R | Poly(ADP-ribose) glycohydrolase | 3.2.1.143 | 0.441 | |
| 8cat | NDP | Catalase | 1.11.1.6 | 0.441 | |
| 1nyt | NAP | Shikimate dehydrogenase (NADP(+)) | / | 0.440 | |
| 2g22 | 6IG | Renin | 3.4.23.15 | 0.440 | |
| 3oet | NAD | Erythronate-4-phosphate dehydrogenase | / | 0.440 |