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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1qrqNDPVoltage-gated potassium channel subunit beta-2

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1qrqNDPVoltage-gated potassium channel subunit beta-2/1.000
4jtdNAPVoltage-gated potassium channel subunit beta-2/0.639
4jtaNAPVoltage-gated potassium channel subunit beta-2/0.605
3lnmNAPVoltage-gated potassium channel subunit beta-2/0.589
4g5dNDPProstaglandin F synthase1.1.1.1880.565
1az2NAPAldose reductase1.1.1.210.522
1m9hNAD2,5-diketo-D-gluconic acid reductase A1.1.1.3460.522
2acuNAPAldose reductase1.1.1.210.521
2j8tNAPAldose reductase1.1.1.210.520
3v36NAPAldose reductase1.1.1.210.518
1adsNAPAldose reductase1.1.1.210.517
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.516
3lutNAPVoltage-gated potassium channel subunit beta-2/0.510
2pfhNDPAldose reductase1.1.1.210.508
2acsNAPAldose reductase1.1.1.210.505
1ye6NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.503
2pf8NDPAldose reductase1.1.1.210.503
3o3rNAPAldose reductase-related protein 11.1.1.210.501
4l1xNAPAldo-keto reductase family 1 member C2/0.497
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.496
4xo7NAPAldo-keto reductase family 1 member C2/0.496
1x96NAPAldose reductase1.1.1.210.493
3qkzNAPAldose reductase-related protein 11.1.1.210.493
2pevNDPAldose reductase1.1.1.210.491
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.490
1ye4NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.489
2iq0NAPAldose reductase1.1.1.210.489
1z8aNAPAldose reductase1.1.1.210.488
2acqNAPAldose reductase1.1.1.210.487
1x98NAPAldose reductase1.1.1.210.486
4jtqNAPAldo-keto reductase family 1 member C2/0.484
1z9aNADNAD(P)H-dependent D-xylose reductase1.1.1.3070.483
1ah4NAPAldose reductase1.1.1.210.481
1c9wNAPAldose reductase-related protein 2/0.480
1pz1NAPGeneral stress protein 69/0.480
1a80NDP2,5-diketo-D-gluconic acid reductase A1.1.1.3460.476
2bgsNDPAldose reductase1.1.1.210.475
4jq3NAPAldo-keto reductase family 1 member C2/0.475
1hqtNAPAlcohol dehydrogenase [NADP(+)]1.1.1.20.473
2hdjNDPAldo-keto reductase family 1 member C2/0.472
2hejNDPAldo-keto reductase family 1 member C211.1.10.462
1ye6NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.461
1mi3NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.460
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.460
3h7rNAPAldo-keto reductase family 4 member C8/0.460
1sm9NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.458
2c91NAPAflatoxin B1 aldehyde reductase member 2/0.456
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.455
1r38NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.454
2clpNDPAflatoxin B1 aldehyde reductase member 3/0.452
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.452
3q67NAPAldose reductase1.1.1.210.451
5c7hNDPPutative oxidoreductase/0.449
1vp5NAPOxidoreductase, aldo/keto reductase family/0.447
3q65NAPAldose reductase1.1.1.210.446
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.444
1s1rNAPAldo-keto reductase family 1 member C3/0.443
2p5nNDPAldo-keto reductase family 1 member C211.1.10.443
4omaLCSMethionine gamma-lyase/0.443
4itxIN5Cystathionine beta-lyase MetC4.4.1.80.441
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.440