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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1j7kATPHolliday junction ATP-dependent DNA helicase RuvB

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1j7kATPHolliday junction ATP-dependent DNA helicase RuvB/1.000
4aw0ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.457
2zdt46CMitogen-activated protein kinase 102.7.11.240.456
4xx9ATP3-phosphoinositide-dependent protein kinase 12.7.11.10.454
4xuhSFIPeroxisome proliferator-activated receptor gamma/0.452
2qoqANPEphrin type-A receptor 32.7.10.10.451
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
4iwo1H4Serine/threonine-protein kinase TBK12.7.11.10.450
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.449
1l8qADPChromosomal replication initiator protein DnaA/0.447
3aljFAD2-methyl-3-hydroxypyridine-5-carboxylic acid oxygenase/0.447
4lb2DM5Serum albumin/0.447
2b1pAIZMitogen-activated protein kinase 102.7.11.240.446
4rqvATP3-phosphoinositide-dependent protein kinase 12.7.11.10.446
2qo9ANPEphrin type-A receptor 32.7.10.10.445
3t3r9PLCytochrome P450 2A61.14.130.445
2om9AJAPeroxisome proliferator-activated receptor gamma/0.443
1kzjCB3Thymidylate synthase/0.442
2e2qADPATP-dependent hexokinase/0.442
2j2pSC2Ficolin-2/0.442
1v9aSAHUncharacterized protein/0.441
2a84ATPPantothenate synthetase6.3.2.10.441
2ceoT44Thyroxine-binding globulin/0.441
1nzdUPGDNA beta-glucosyltransferase/0.440
3upf0BUPolyprotein/0.440
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.440