sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Cavities are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase |
| PDB ID | HET | Uniprot Name | EC Number | Cavity Similarity |
Align |
|---|---|---|---|---|---|
| 1fpq | SAM | Isoliquiritigenin 2'-O-methyltransferase | / | 1.000 | |
| 1mkd | ZAR | cAMP-specific 3',5'-cyclic phosphodiesterase 4D | 3.1.4.53 | 0.477 | |
| 2itq | ITQ | Epidermal growth factor receptor | 2.7.10.1 | 0.475 | |
| 4ktk | KTK | Cytochrome P450 | / | 0.463 | |
| 2vn0 | TDZ | Cytochrome P450 2C8 | / | 0.461 | |
| 3fwj | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.457 | |
| 4ez7 | 2AN | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.455 | |
| 1fp1 | HCC | Isoliquiritigenin 2'-O-methyltransferase | / | 0.453 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.453 | |
| 2e98 | B29 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.452 | |
| 4dc0 | NDP | Putative ketoacyl reductase | 1.3.1 | 0.452 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.451 | |
| 3tqh | NDP | Quinone oxidoreductase | / | 0.451 | |
| 4bgi | I4I | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.450 | |
| 4xcv | NDP | Probable hydroxyacid dehydrogenase protein | / | 0.450 | |
| 3lxi | CAM | Cytochrome P450 | / | 0.449 | |
| 3hdh | NAD | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial | 1.1.1.35 | 0.447 | |
| 4iq7 | 1G9 | Mycocyclosin synthase | 1.14.21.9 | 0.447 | |
| 6cp4 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.447 | |
| 4g2g | TDH | Mycocyclosin synthase | 1.14.21.9 | 0.445 | |
| 4u9a | STU | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.445 | |
| 2rhr | EMO | Putative ketoacyl reductase | 1.3.1 | 0.444 | |
| 3ics | ADP | Coenzyme A disulfide reductase | / | 0.444 | |
| 3klj | FAD | NADH-rubredoxin oxidoreductase | 1.18.1.1 | 0.444 | |
| 4jaz | STL | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.444 | |
| 4ubs | DIF | Pentalenic acid synthase | 1.14.15.11 | 0.444 | |
| 4xwt | U5P | Ribonuclease J | / | 0.444 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.443 | |
| 3frq | ERY | Erythromycin resistance repressor protein | / | 0.442 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.442 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.441 | |
| 3v8w | 0G2 | Tyrosine-protein kinase ITK/TSK | 2.7.10.2 | 0.441 | |
| 3cge | NDP | Coenzyme A disulfide reductase | / | 0.440 | |
| 3s1d | ZIR | Cytokinin dehydrogenase 1 | 1.5.99.12 | 0.440 | |
| 4kla | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.440 | |
| 5cpb | NAD | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.440 |