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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1ebdFADDihydrolipoyl dehydrogenase1.8.1.4

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1ebdFADDihydrolipoyl dehydrogenase1.8.1.41.000
3sqpFADGlutathione reductase, mitochondrial1.8.1.70.499
4jq9FADDihydrolipoyl dehydrogenase/0.499
1zk7FADMercuric reductase1.16.1.10.490
1lvlFADDihydrolipoyl dehydrogenase1.8.1.40.488
2gh5FADGlutathione reductase, mitochondrial1.8.1.70.483
4jdrFADDihydrolipoyl dehydrogenase1.8.1.40.483
1lpfFADDihydrolipoyl dehydrogenase1.8.1.40.480
2f5zFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.477
3grsFADGlutathione reductase, mitochondrial1.8.1.70.477
2qaeFADDihydrolipoyl dehydrogenase1.8.1.40.476
2eq8FADDihydrolipoyl dehydrogenase/0.470
1zmcFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.468
1zx9FADMercuric reductase1.16.1.10.468
1zy8FADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.467
2eq6FADDihydrolipoyl dehydrogenase/0.467
4gr1FADGlutathione reductase, mitochondrial1.8.1.70.467
2eq9FADDihydrolipoyl dehydrogenase/0.466
3rnmFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.463
1jehFADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.460
1grhFADGlutathione reductase, mitochondrial1.8.1.70.458
1k4qFADGlutathione reductase, mitochondrial1.8.1.70.457
2r9zFADGlutathione amide reductase/0.452
1nhqFADNADH peroxidase1.11.1.10.446
2cfyFADThioredoxin reductase 1, cytoplasmic1.8.1.90.445
2j3nFADThioredoxin reductase 1, cytoplasmic1.8.1.90.443