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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Cavity similarities measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Cavities are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299

Reference Protein Data Bank Entry :
PDB ID HET Uniprot Name EC Number
1bdbNADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase

Complex with similar cavities

PDB ID HET Uniprot Name EC Number Cavity
Similarity		 Align
1bdbNADCis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase/1.000
3r3sNADPutative oxidoreductase/0.499
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.485
3p19NDPPutative blue fluorescent protein/0.485
2wsbNADGalactitol dehydrogenase/0.480
4hwkNAPSepiapterin reductase1.1.1.1530.479
2wdzNADGalactitol dehydrogenase/0.477
4bmvNAPShort-chain dehydrogenase/0.477
5jydNADShort chain dehydrogenase/0.476
3d3wNAPL-xylulose reductase1.1.1.100.473
1uayADNOxidoreductase/0.471
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.470
1fduNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.465
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.465
2ylrNAPPhenylacetone monooxygenase1.14.13.920.463
3w8eNAD3-hydroxybutyrate dehydrogenase/0.463
1xg5NAPDehydrogenase/reductase SDR family member 11/0.460
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.460
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.458
4cqlNADEstradiol 17-beta-dehydrogenase 81.1.1.620.456
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.454
1xkqNDPUncharacterized protein/0.452
3gegNADShort-chain dehydrogenase/reductase SDR/0.452
4q71FADBifunctional protein PutA/0.451
2a92NAIL-lactate dehydrogenase/0.450
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.449
4j7xNAPSepiapterin reductase1.1.1.1530.449
3up4FAD2-oxo-Delta(3)-4,5,5-trimethylcyclopentenylacetyl-CoA monooxygenase1.14.13.1600.448
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.447
1dxyNADD-2-hydroxyisocaproate dehydrogenase1.1.10.446
3l77NJPShort-chain alcohol dehydrogenase/0.446
1ae1NAPTropinone reductase 1/0.445
2z1mNDPGDP-mannose 4,6-dehydratase/0.444
1iy8NADLevodione reductase/0.443
1pr9NAPL-xylulose reductase1.1.1.100.443
1snyNAPLD36273p/0.443
3rk1ATPN-type ATP pyrophosphatase superfamily/0.443
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.442
3opxU5PSuppressor of disruption of TFIIS/0.442
4oaqNDPR-specific carbonyl reductase/0.442
2ohxNADAlcohol dehydrogenase E chain1.1.1.10.440
4j7uNAPSepiapterin reductase1.1.1.1530.440