Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5mdhNADMalate dehydrogenase, cytoplasmic1.1.1.37

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5mdhNADMalate dehydrogenase, cytoplasmic1.1.1.371.000
4nd2A3DLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.548
2a92NAIL-lactate dehydrogenase/0.539
4wluNADMalate dehydrogenase, mitochondrial1.1.1.370.538
5a1tNAIL-lactate dehydrogenase/0.531
1pzfA3DLactate dehydrogenase/0.526
1pzgA3DLactate dehydrogenase/0.522
2hjrAPRMalate dehydrogenase, adjacent gene encodes predicted lactate dehydrogenase/0.522
1sowNADL-lactate dehydrogenase1.1.1.270.516
4nd4NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.513
4wlvNADMalate dehydrogenase, mitochondrial1.1.1.370.512
4oknNAIL-lactate dehydrogenase A chain1.1.1.270.507
1t2dNADL-lactate dehydrogenase1.1.1.270.506
4ajp88NL-lactate dehydrogenase A chain1.1.1.270.506
1hyhNADL-2-hydroxyisocaproate dehydrogenase/0.500
4ajo88NL-lactate dehydrogenase A chain1.1.1.270.500
1ie3NADMalate dehydrogenase/0.489
4wloNAIMalate dehydrogenase, mitochondrial1.1.1.370.489
2fn7NADLactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase/0.485
1mgoNADAlcohol dehydrogenase E chain1.1.1.10.483
2aa3AP0L-lactate dehydrogenase/0.480
1ma0NADAlcohol dehydrogenase class-31.1.1.10.479
2vhvNAIAlanine dehydrogenase1.4.1.10.477
1zemNADXylitol dehydrogenase/0.475
4gkvNADAlcohol dehydrogenase, propanol-preferring1.1.1.10.473
4l4sNAIL-lactate dehydrogenase A chain1.1.1.270.472
4dwvNAJAlcohol dehydrogenase E chain1.1.1.10.470
1adbCNDAlcohol dehydrogenase E chain1.1.1.10.467
2fzeAPRAlcohol dehydrogenase class-31.1.1.10.465
2jhfNADAlcohol dehydrogenase E chain1.1.1.10.461
1agnNADAlcohol dehydrogenase class 4 mu/sigma chain1.1.1.10.460
4dlbNADS-(hydroxymethyl)glutathione dehydrogenase/0.460
4dl9NADS-(hydroxymethyl)glutathione dehydrogenase/0.458
3twoNDPMannitol dehydrogenase/0.457
4jjiNADAlcohol dehydrogenase class-3/0.456
4gl4NAIAlcohol dehydrogenase class-3/0.455
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.454
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.452
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.452
4ng5NAJAlcohol dehydrogenase E chain1.1.1.10.452
1adcPADAlcohol dehydrogenase E chain1.1.1.10.449
1r37NADNAD-dependent alcohol dehydrogenase1.1.1.10.449
4nfhNAJAlcohol dehydrogenase E chain1.1.1.10.449
2xaaNADSecondary alcohol dehydrogenase/0.448
2vhzNAIAlanine dehydrogenase1.4.1.10.447
1vjtNADAlpha-glucosidase, putative/0.445
1a71NADAlcohol dehydrogenase E chain1.1.1.10.442
1cdoNADAlcohol dehydrogenase 11.1.1.10.442
1lluNADAlcohol dehydrogenase/0.442
3jv7NADSecondary alcohol dehydrogenase/0.442
1ht0NADAlcohol dehydrogenase 1C1.1.1.10.441
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.440
2vhxNADAlanine dehydrogenase1.4.1.10.440
3d64NADAdenosylhomocysteinase/0.440