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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5l8lADPAurora kinase A2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5l8lADPAurora kinase A2.7.11.11.000
4c3pACPAurora kinase A2.7.11.10.605
2wqeADPAurora kinase A2.7.11.10.583
3k5uPFQAurora kinase A2.7.11.10.537
2ijmATPFocal adhesion kinase 12.7.10.20.532
4o0uADNAurora kinase A2.7.11.10.528
3efwAK8Aurora kinase A2.7.11.10.513
2bmcMPYAurora kinase A2.7.11.10.509
4jboWPHAurora kinase A2.7.11.10.499
2c6eHPMAurora kinase A2.7.11.10.493
4jbqVX6Aurora kinase A2.7.11.10.493
4jbpYPHAurora kinase A2.7.11.10.487
5dosATPAurora kinase A2.7.11.10.487
2j0lANPFocal adhesion kinase 12.7.10.20.479
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.479
3c4zADPRhodopsin kinase/0.475
5dnrATPAurora kinase A2.7.11.10.475
3c4xATPRhodopsin kinase/0.474
2qoqANPEphrin type-A receptor 32.7.10.10.473
1bygSTUTyrosine-protein kinase CSK/0.471
2henADPEphrin type-B receptor 22.7.10.10.468
4qmlANPSerine/threonine-protein kinase 242.7.11.10.467
3c4wATPRhodopsin kinase/0.465
4l9i8PRRhodopsin kinase/0.464
2qo7ANPEphrin type-A receptor 32.7.10.10.463
1i44ACPInsulin receptor2.7.10.10.462
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.460
1jqhANPInsulin-like growth factor 1 receptor2.7.10.10.454
1pmn984Mitogen-activated protein kinase 102.7.11.240.454
3cokANPSerine/threonine-protein kinase PLK42.7.11.210.453
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.453
3qc9ADPRhodopsin kinase/0.449
3w16P9JAurora kinase A2.7.11.10.448
4b0gVEKAurora kinase A2.7.11.10.447
4ysjADPCalmodulin-like domain protein kinase/0.446
4deeADPAurora kinase A2.7.11.10.444
5ap7SVEDual specificity protein kinase TTK2.7.12.10.444
3fhyATPPyridoxal kinase2.7.1.350.443
2w1fL0FAurora kinase A2.7.11.10.442
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.442
3t8oATPRhodopsin kinase/0.441
4j99ACPFibroblast growth factor receptor 2/0.440