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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5i39FADL-amino acid deaminase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5i39FADL-amino acid deaminase/1.000
2rgoFADAlpha-Glycerophosphate Oxidase/0.510
3axbFADPutative oxidoreductase/0.508
2qcuFADAerobic glycerol-3-phosphate dehydrogenase1.1.5.30.507
4bk3FADProbable salicylate monooxygenase/0.489
3vqrFADPutative oxidoreductase/0.485
2c3cFAD2-oxopropyl-CoM reductase, carboxylating1.8.1.50.484
3k4cFADPyranose 2-oxidase/0.484
3wmxNADNAD dependent epimerase/dehydratase/0.484
3ijrNADOxidoreductase, short chain dehydrogenase/reductase family/0.483
4ntdFADThioredoxin reductase/0.481
4yshFADGlycine oxidase/0.474
2fonFADAcyl-coenzyme A oxidase/0.472
4nwzFADFAD-dependent pyridine nucleotide-disulfide oxidoreductase/0.470
4gkvNADAlcohol dehydrogenase, propanol-preferring1.1.1.10.469
2bi7FADUDP-galactopyranose mutase5.4.99.90.467
2rghFADAlpha-Glycerophosphate Oxidase/0.467
3sz0FADSulfide-quinone reductase/0.467
1udyFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.465
3bg7FADPyranose 2-oxidase/0.465
3zdfNADGlyceraldehyde-3-phosphate dehydrogenase/0.465
1tdeFADThioredoxin reductase1.8.1.90.464
2bi8FADUDP-galactopyranose mutase5.4.99.90.464
1xddAAYIntegrin alpha-L/0.463
4haiI23Bifunctional epoxide hydrolase 23.1.3.760.463
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.462
2igoFADPyranose 2-oxidase/0.462
3l8kADPDihydrolipoamide dehydrogenase (PdhD-3)/0.462
3nugNADPyridoxal 4-dehydrogenase1.1.1.1070.462
1mo9FAD2-oxopropyl-CoM reductase, carboxylating1.8.1.50.461
2omeNADC-terminal-binding protein 2/0.460
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.460
2ylzFADPhenylacetone monooxygenase1.14.13.920.459
3b20NADGlyceraldehyde-3-phosphate dehydrogenase/0.459
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.459
4xwzFADFructosyl amine:oxygen oxidoreductase/0.458
1bim0QBRenin3.4.23.150.456
2c0cNAPProstaglandin reductase 310.456
4irnFADAnaB/0.456
2fw3BUICarnitine O-palmitoyltransferase 2, mitochondrial2.3.1.210.455
3r3sNADPutative oxidoreductase/0.455
1w06W05Isopenicillin N synthase1.21.3.10.454
1reoFADL-amino-acid oxidase1.4.3.20.453
3te5NAI5'-AMP-activated protein kinase subunit gamma/0.453
1e3wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.452
4x9nFADUncharacterized protein MG039 homolog/0.452
5dbgNADIridoid synthase1.3.1.990.452
1dxoFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.451
3rf7NADIron-containing alcohol dehydrogenase/0.451
3vydVYDRenin3.4.23.150.451
4d03FADPhenylacetone monooxygenase1.14.13.920.451
1fl2FADAlkyl hydroperoxide reductase subunit F1.8.10.450
1n06ADPRiboflavin kinase2.7.1.260.450
1t9gFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.450
2ebaFADPutative glutaryl-CoA dehydrogenase/0.450
3g7jGTXGlutathione transferase GST1-4/0.450
3nwzCOABH2602 protein/0.450
1e3sNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.449
2v3aFADRubredoxin-NAD(+) reductase1.18.1.10.449
2vnaNAPProstaglandin reductase 21.3.1.480.449
3gqvNAPEnoyl reductase LovC10.449
3mpjFADGlutaryl-CoA dehydrogenase1.3.99.320.449
4iarERM5-hydroxytryptamine receptor 1B/0.448
4yjdFADD-amino-acid oxidase1.4.3.30.448
4yntFDAGlucose oxidase, putative/0.448
2y05NAPProstaglandin reductase 1/0.447
3flkNAITartrate dehydrogenase/decarboxylase1.1.1.930.447
5fs7FADApoptosis-inducing factor 1, mitochondrial1.1.10.447
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.446
3b70NAPEnoyl reductase LovC10.446
3kybFADUDP-galactopyranose mutase5.4.99.90.446
3sjuNDPKeto reductase/0.446
4kx6FADFumarate reductase flavoprotein subunit1.3.5.40.446
1nq5NADGlyceraldehyde-3-phosphate dehydrogenase/0.445
3q44D50M1 family aminopeptidase3.4.110.445
4kzoNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.445
4rvuNDPProbable quinone reductase Qor (NADPH:quinone reductase) (Zeta-crystallin homolog protein)/0.445
5ez7FADProbable FAD-dependent oxidoreductase PA4991/0.445
1aa6MGDFormate dehydrogenase H1.1.99.330.444
3mddFADMedium-chain specific acyl-CoA dehydrogenase, mitochondrial1.3.8.70.444
1fm9570Peroxisome proliferator-activated receptor gamma/0.443
2fy4COACholine O-acetyltransferase2.3.1.60.443
2ylwFADPhenylacetone monooxygenase1.14.13.920.443
3cgeFADCoenzyme A disulfide reductase/0.443
3etgNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.443
3r7kFDAProbable acyl CoA dehydrogenase/0.443
4kcfAKMFAD-dependent oxidoreductase/0.443
1f0xFADD-lactate dehydrogenase1.1.1.280.442
1v9nNDPMalate dehydrogenase1.1.1.370.442
1w4xFADPhenylacetone monooxygenase1.14.13.920.442
1zmcNADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.442
2zb3NDPProstaglandin reductase 21.3.1.480.442
3sdkP3NProteasome subunit beta type-53.4.25.10.442
3sdkP3NProteasome subunit beta type-63.4.25.10.442
4bc7FADAlkyldihydroxyacetonephosphate synthase, peroxisomal2.5.1.260.442
4dh60KNBeta-secretase 13.4.23.460.442
1f8sFADL-amino-acid oxidase1.4.3.20.441
1gqtACPRibokinase/0.441
2pmdGNPTranslation initiation factor 2 subunit gamma/0.441
3fhyATPPyridoxal kinase2.7.1.350.441
3w6uNAP6-phosphogluconate dehydrogenase, NAD-binding protein/0.441
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.441
4gevCB3Thymidylate synthase/0.441
5jscFADPutative acyl-CoA dehydrogenase/0.441
1sveI01cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.440
2a7r5GPGMP reductase 2/0.440
2c3dFAD2-oxopropyl-CoM reductase, carboxylating1.8.1.50.440
2ozuACOHistone acetyltransferase KAT6A/0.440
2tpsTPSThiamine-phosphate synthase/0.440
3wv7ADPHmd co-occurring protein HcgE/0.440
4tm0FADKtzI/0.440
4tvbNADHomospermidine synthase2.5.1.440.440