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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5eccNAPDehydrofolate reductase type I

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5eccNAPDehydrofolate reductase type I/1.000
3qlsNDPDihydrofolate reductase1.5.1.30.613
3qlrNDPDihydrofolate reductase1.5.1.30.608
3clbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.591
1ai9NDPDihydrofolate reductase1.5.1.30.581
1ia1NDPDihydrofolate reductase1.5.1.30.579
2h2qNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.576
3kjsNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.574
3d84NDPDihydrofolate reductase1.5.1.30.567
3invNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.563
2cig1DGDihydrofolate reductase1.5.1.30.559
1m78NDPDihydrofolate reductase1.5.1.30.557
1rx1NAPDihydrofolate reductase1.5.1.30.554
3dgaNDPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.551
2w3bNDPDihydrofolate reductase1.5.1.30.548
1dr3TAPDihydrofolate reductase1.5.1.30.545
3tqaNDPDihydrofolate reductase/0.545
1dr2TAPDihydrofolate reductase1.5.1.30.539
3nxxNDPDihydrofolate reductase1.5.1.30.536
3hbbNAPBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.513
1dr5NAPDihydrofolate reductase1.5.1.30.508
4m6jNDPDihydrofolate reductase1.5.1.30.508
1ia4TQ6Dihydrofolate reductase1.5.1.30.499
1drhNAPDihydrofolate reductase1.5.1.30.498
3kjrNAPBifunctional dihydrofolate reductase-thymidylate synthase/0.493
1ia3TQ5Dihydrofolate reductase1.5.1.30.492
1iolESTEstradiol 17-beta-dehydrogenase 11.1.1.620.490
3pm9FADPutative oxidoreductase/0.484
4dl9NADS-(hydroxymethyl)glutathione dehydrogenase/0.476
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.475
1e3eNAIAlcohol dehydrogenase 41.1.1.10.473
1tehNADAlcohol dehydrogenase class-31.1.1.10.473
1ma0NADAlcohol dehydrogenase class-31.1.1.10.472
2w9hTOPDihydrofolate reductase1.5.1.30.471
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.469
2y0mACOHistone acetyltransferase KAT8/0.460
3oafOAGDihydrofolate reductase1.5.1.30.460
3qrwNDPPutative ketoacyl reductase1.3.10.460
1lf3EH5Plasmepsin-23.4.23.390.458
4nmdFDABifunctional protein PutA/0.458
2xw7NDPDihydrofolate reductase/0.457
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.457
1bim0QBRenin3.4.23.150.456
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.456
3b6zCO7Enoyl reductase LovC10.456
4ambDUDPutative glycosyl transferase/0.456
4l0qNADAlcohol dehydrogenase class-3/0.456
1rx8FOLDihydrofolate reductase1.5.1.30.455
2ou2ACOHistone acetyltransferase KAT5/0.455
3gqvNAPEnoyl reductase LovC10.455
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.455
4nxuADPMitochondrial dynamics protein MID51/0.455
1osvCHCBile acid receptor/0.453
1y0s331Peroxisome proliferator-activated receptor delta/0.453
4q73FADBifunctional protein PutA/0.453
3a9wNADNDP-sugar epimerase/0.452
3g5qFADMethylenetetrahydrofolate--tRNA-(uracil-5-)-methyltransferase TrmFO/0.452
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.452
2zb3NDPProstaglandin reductase 21.3.1.480.451
3mvm39PMitogen-activated protein kinase 14/0.450
4djaFAD(6-4) photolyase/0.450
4nieNBHNuclear receptor ROR-gamma/0.450
5dqrFAD7-hydroxymethyl chlorophyll a reductase, chloroplastic1.17.7.20.450
1ipeNDPTropinone reductase 21.1.1.2360.448
3b70NAPEnoyl reductase LovC10.448
3gw9VNILanosterol 14-alpha-demethylase/0.448
4anuEM7Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform2.7.1.1530.448
4oztP1AEcdysone receptor, putative/0.448
4q72FADBifunctional protein PutA/0.448
1xe65FPPlasmepsin-23.4.23.390.447
4bfxZVXPantothenate kinase2.7.1.330.447
2c54NADGDP-mannose 3,5-epimerase5.1.3.180.446
3vrwYS5Vitamin D3 receptor/0.445
4ly91YYGlucokinase regulatory protein/0.445
1xddAAYIntegrin alpha-L/0.444
1jolFFODihydrofolate reductase1.5.1.30.443
2y3rTRKTamL/0.443
3bw4FMNPutative 2-nitropropane dioxygenase/0.443
3f1kNAPUncharacterized oxidoreductase YciK10.443
4q71FADBifunctional protein PutA/0.443
4tuvCPZCytochrome P450 1191.140.443
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.443
1i7gAZ2Peroxisome proliferator-activated receptor alpha/0.442
1ot7IU5Bile acid receptor/0.442
3jzdNADMaleylacetate reductase/0.442
3lpiZ74Beta-secretase 13.4.23.460.442
2a94AP0L-lactate dehydrogenase1.1.1.270.441
2gjlFMNNitronate monooxygenase1.13.12.160.441
2nq8ZIDEnoyl-ACP reductase/0.441
2ztvNADD(-)-3-hydroxybutyrate dehydrogenase/0.441
3umpATPATP-dependent 6-phosphofructokinase isozyme 22.7.1.110.441
4hfr14MCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
2y8qADP5'-AMP-activated protein kinase subunit gamma-1/0.440
3c1y2BADNA integrity scanning protein DisA/0.440
3dheANDEstradiol 17-beta-dehydrogenase 11.1.1.620.440
4y8wSTRSteroid 21-hydroxylase/0.440