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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
5bvw1N1Epithelial discoidin domain-containing receptor 12.7.10.11.000
4v010LIFibroblast growth factor receptor 1 (Fms-related tyrosine kinase 2, Pfeiffer syndrome), isoform CRA_b/0.517
4tyj0LIFibroblast growth factor receptor 42.7.10.10.504
2z2w770Wee1-like protein kinase2.7.10.20.502
3bi6396Wee1-like protein kinase2.7.10.20.493
4fk3325Serine/threonine-protein kinase B-raf2.7.11.10.489
4fnyI3KALK tyrosine kinase receptor2.7.10.10.487
2rl52RLVascular endothelial growth factor receptor 22.7.10.10.484
3oezSTIProto-oncogene tyrosine-protein kinase Src2.7.10.20.481
1qpjSTUTyrosine-protein kinase Lck2.7.10.20.480
3prfFP3Serine/threonine-protein kinase B-raf2.7.11.10.480
4uxq0LIFibroblast growth factor receptor 42.7.10.10.480
1x8b824Wee1-like protein kinase2.7.10.20.479
4i6h1C8Serine/threonine-protein kinase PLK22.7.11.210.478
2gqg1N1Tyrosine-protein kinase ABL12.7.10.20.477
2in6839Wee1-like protein kinase2.7.10.20.474
3cqeP91Wee1-like protein kinase2.7.10.20.472
1qpdSTUTyrosine-protein kinase Lck2.7.10.20.469
2dq7STUTyrosine-protein kinase Fyn2.7.10.20.469
2hog710Serine/threonine-protein kinase Chk12.7.11.10.469
3biz61EWee1-like protein kinase2.7.10.20.468
1bygSTUTyrosine-protein kinase CSK/0.467
3oct1N1Tyrosine-protein kinase BTK2.7.10.20.467
5e8wSTUTGF-beta receptor type-12.7.11.300.467
3qlg1N1Proto-oncogene tyrosine-protein kinase Src2.7.10.20.466
3b8q900Vascular endothelial growth factor receptor 22.7.10.10.465
4gmy0X5Tyrosine-protein kinase JAK2/0.465
3be2RAJVascular endothelial growth factor receptor 22.7.10.10.463
4nka2K7Fibroblast growth factor receptor 1/0.463
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.462
3tubFPUTyrosine-protein kinase SYK2.7.10.20.462
4wo5324Serine/threonine-protein kinase B-raf2.7.11.10.462
4qrc0LIFibroblast growth factor receptor 42.7.10.10.461
3zewSTUEphrin type-B receptor 42.7.10.10.460
4g34924Eukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.459
2p2h994Vascular endothelial growth factor receptor 22.7.10.10.458
3ctj320Hepatocyte growth factor receptor2.7.10.10.457
3ppkFNISerine/threonine-protein kinase B-raf2.7.11.10.457
4dggI76Proto-oncogene tyrosine-protein kinase Src2.7.10.20.457
4g310WHEukaryotic translation initiation factor 2-alpha kinase 32.7.11.10.456
2fb8215Serine/threonine-protein kinase B-raf2.7.11.10.454
3e5aVX6Aurora kinase A2.7.11.10.454
3gxlQIGTGF-beta receptor type-12.7.11.300.453
3cth319Hepatocyte growth factor receptor2.7.10.10.452
4jia1K3Tyrosine-protein kinase JAK2/0.452
2qo9ANPEphrin type-A receptor 32.7.10.10.451
4i6f1C7Serine/threonine-protein kinase PLK22.7.11.210.450
4j97ACPFibroblast growth factor receptor 2/0.450
2io6330Wee1-like protein kinase2.7.10.20.447
2r0uM54Serine/threonine-protein kinase Chk12.7.11.10.447
2y6o1N1Ephrin type-A receptor 42.7.10.10.447
3eta351Insulin receptor2.7.10.10.447
4bidIE8Mitogen-activated protein kinase kinase kinase 52.7.11.250.447
4bkjSTIEpithelial discoidin domain-containing receptor 12.7.10.10.447
4h1j0YHProtein-tyrosine kinase 2-beta2.7.10.20.447
1pmn984Mitogen-activated protein kinase 102.7.11.240.446
3ttjJBIMitogen-activated protein kinase 102.7.11.240.446
2g2hP16Tyrosine-protein kinase ABL12.7.10.20.445
4jqh1MFAlr2278 protein/0.445
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.444
3mtfA3FActivin receptor type-12.7.11.300.444
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.444
3dh7FMNIsopentenyl-diphosphate delta-isomerase/0.443
5amnDTQProto-oncogene tyrosine-protein kinase receptor Ret2.7.10.10.443
3b8r887Vascular endothelial growth factor receptor 22.7.10.10.442
5dp2NAPCurF/0.442
3cjgKIMVascular endothelial growth factor receptor 22.7.10.10.441
3oom507Activin receptor type-12.7.11.300.441
4c3f7KWTyrosine-protein kinase Lck2.7.10.20.441
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.441
3tkiS25Serine/threonine-protein kinase Chk12.7.11.10.440
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.440