sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4xyb | NDP | Formate dehydrogenase |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4xyb | NDP | Formate dehydrogenase | / | 1.000 | |
| 4xye | NAD | Formate dehydrogenase | / | 0.633 | |
| 1n5d | NDP | Carbonyl reductase [NADPH] 1 | / | 0.472 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.472 | |
| 3flk | NAI | Tartrate dehydrogenase/decarboxylase | 1.1.1.93 | 0.467 | |
| 4qi5 | FAD | Cellobiose dehydrogenase | / | 0.467 | |
| 3fvl | BHK | Carboxypeptidase A1 | 3.4.17.1 | 0.464 | |
| 3rha | FDA | Putrescine oxidase | / | 0.463 | |
| 3inm | NDP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.462 | |
| 4bca | FAD | Alkyldihydroxyacetonephosphate synthase, peroxisomal | 2.5.1.26 | 0.460 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.457 | |
| 4bv9 | NDP | Ketimine reductase mu-crystallin | 1.5.1.25 | 0.457 | |
| 4f7i | NAD | 3-isopropylmalate dehydrogenase | 1.1.1.85 | 0.457 | |
| 3lpi | Z74 | Beta-secretase 1 | 3.4.23.46 | 0.456 | |
| 3gfb | NAD | L-threonine 3-dehydrogenase | / | 0.454 | |
| 3bg7 | FAD | Pyranose 2-oxidase | / | 0.453 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.450 | |
| 3mdv | CL6 | Cholesterol 24-hydroxylase | / | 0.450 | |
| 3q43 | D66 | M1 family aminopeptidase | 3.4.11 | 0.450 | |
| 3zc3 | NAP | Ferredoxin--NADP reductase | 1.18.1.2 | 0.449 | |
| 1g9r | UPF | LgtC | / | 0.448 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.448 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.448 | |
| 1f4f | TP3 | Thymidylate synthase | / | 0.447 | |
| 1ege | FAD | Medium-chain specific acyl-CoA dehydrogenase, mitochondrial | 1.3.8.7 | 0.446 | |
| 3kyt | HC2 | Nuclear receptor ROR-gamma | / | 0.446 | |
| 4a99 | FAD | TetX family tetracycline inactivation enzyme | / | 0.445 | |
| 1bws | NDP | GDP-L-fucose synthase | / | 0.444 | |
| 1osv | CHC | Bile acid receptor | / | 0.444 | |
| 3ggo | NAI | Prephenate dehydrogenase | / | 0.444 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 3hdy | FDA | UDP-galactopyranose mutase | / | 0.443 | |
| 3qfc | NAP | NADPH--cytochrome P450 reductase | / | 0.443 | |
| 3stv | 3HO | Methylketone synthase I | / | 0.443 | |
| 3uhm | RFN | UDP-3-O-acyl-N-acetylglucosamine deacetylase | / | 0.443 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.443 | |
| 4c7k | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.442 | |
| 4mih | FAD | Pyranose 2-oxidase | 1.1.3.10 | 0.442 | |
| 4wda | 2AM | 2',3'-cyclic-nucleotide 3'-phosphodiesterase | 3.1.4.37 | 0.442 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.441 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.441 | |
| 1ppj | ANY | Cytochrome b | / | 0.441 | |
| 1pr9 | NAP | L-xylulose reductase | 1.1.1.10 | 0.441 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.441 | |
| 2ywl | FAD | Thioredoxin reductase related protein | / | 0.440 | |
| 2ztm | NAD | D(-)-3-hydroxybutyrate dehydrogenase | / | 0.440 | |
| 4kx6 | FAD | Fumarate reductase flavoprotein subunit | 1.3.5.4 | 0.440 | |
| 4nie | NBH | Nuclear receptor ROR-gamma | / | 0.440 | |
| 5dp2 | NAP | CurF | / | 0.440 |