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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4tv9GTPTubulin alpha-1B chain

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4tv9GTPTubulin alpha-1B chain/1.000
4wbnGTPTubulin alpha-1B chain/0.804
4ihjGTPTubulin alpha-1B chain/0.762
4tuyGTPTubulin alpha-1B chain/0.747
5la6GTPTubulin alpha-1B chain/0.734
4o4iGTPTubulin alpha-1B chain/0.717
4iijGTPTubulin alpha-1B chain/0.687
4zolGTPTubulin alpha-1B chain/0.649
4o4lGTPTubulin alpha-1B chain/0.635
3ryhGTPTubulin alpha chain/0.623
5jqgGTPTubulin alpha-1B chain/0.616
4ffbGTPTubulin alpha-1 chain/0.570
4yj2GTPTubulin alpha-1B chain/0.525
4u3jGTPTubulin beta chain/0.508
1xdpATPPolyphosphate kinase/0.468
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.468
5itzGTPTubulin alpha-1B chain/0.468
4f6rGDPTubulin beta chain/0.465
4kgkGTPUncharacterized protein/0.462
2ql6ADPNicotinamide riboside kinase 1/0.460
2o12FMNChorismate synthase/0.459
2getCOKPantothenate kinase2.7.1.330.458
2z4sADPChromosomal replication initiator protein DnaA/0.458
2zseACPPantothenate kinase2.7.1.330.458
4eakATP5'-AMP-activated protein kinase subunit gamma-1/0.457
3af4GCPPantothenate kinase2.7.1.330.455
3zidGDPTubulin-like protein CetZ/0.455
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.454
2ojtUBAGlutamate receptor ionotropic, kainate 1/0.451
2f3rG5PGuanylate kinase2.7.4.80.450
5a88ADPRiboflavin biosynthesis protein RibF2.7.1.260.449
3wqmB29Diterpene synthase3.1.7.80.448
2jbsFMNp-hydroxyphenylacetate 3-hydroxylase, oxygenase component/0.447
2qenADPWalker-Type ATPase/0.447
2qimZEAClass 10 plant pathogenesis-related protein/0.445
4gz612VUDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit/0.445
1qm5PLPMaltodextrin phosphorylase2.4.1.10.444
1tehNADAlcohol dehydrogenase class-31.1.1.10.444
2aa3AP0L-lactate dehydrogenase/0.444
2gesCOKPantothenate kinase2.7.1.330.444
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.443
3tr05GPGuanylate kinase/0.443
3eu5GBOProtein farnesyltransferase subunit beta2.5.1.580.442
2y4gTIRTamL/0.441
4bfsZVSPantothenate kinase2.7.1.330.441
1zp4FAD5,10-methylenetetrahydrofolate reductase1.5.1.200.440