sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4pyn | SAH | Catechol O-methyltransferase | 2.1.1.6 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4pyn | SAH | Catechol O-methyltransferase | 2.1.1.6 | 1.000 | |
| 3u81 | SAH | Catechol O-methyltransferase | 2.1.1.6 | 0.784 | |
| 5kwv | ANP | Pantothenate synthetase | / | 0.499 | |
| 1vik | BAY | Gag-Pol polyprotein | / | 0.459 | |
| 1sve | I01 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.457 | |
| 2acx | ANP | G protein-coupled receptor kinase 6 | 2.7.11.16 | 0.456 | |
| 3oad | LPO | Renin | 3.4.23.15 | 0.456 | |
| 4dbz | NDP | Putative ketoacyl reductase | 1.3.1 | 0.456 | |
| 4ge9 | 0L0 | Kynurenine/alpha-aminoadipate aminotransferase, mitochondrial | 2.6.1.39 | 0.455 | |
| 1hyg | NAP | L-2-hydroxycarboxylate dehydrogenase (NAD(P)(+)) | / | 0.454 | |
| 3ioe | A7D | Pantothenate synthetase | 6.3.2.1 | 0.454 | |
| 4fry | NAD | Putative signal-transduction protein with CBS domains | / | 0.454 | |
| 1omo | NAD | Alanine dehydrogenase | / | 0.451 | |
| 3rai | X85 | Cyclin-dependent kinase 2 | 2.7.11.22 | 0.450 | |
| 1cjv | DAD | Adenylate cyclase type 2 | / | 0.449 | |
| 1cjv | DAD | Adenylate cyclase type 5 | / | 0.449 | |
| 1uda | UFG | UDP-glucose 4-epimerase | 5.1.3.2 | 0.449 | |
| 3a1c | ACP | Probable copper-exporting P-type ATPase A | 3.6.3.54 | 0.448 | |
| 4nd3 | NAD | Lactate dehydrogenase, adjacent gene encodes predicted malate dehydrogenase | / | 0.448 | |
| 1o97 | FAD | Electron transfer flavoprotein subunit alpha | / | 0.447 | |
| 4hp8 | NAP | 2-deoxy-D-gluconate 3-dehydrogenase | / | 0.447 | |
| 2a5h | SAM | L-lysine 2,3-aminomutase | 5.4.3.2 | 0.445 | |
| 2p3b | 3TL | V-1 PROTEASE protein | / | 0.445 | |
| 2p3b | 3TL | V-1 protease | / | 0.445 | |
| 3zxi | TYA | Tyrosine--tRNA ligase, mitochondrial | 6.1.1.1 | 0.445 | |
| 2oap | ANP | Type II secretion system protein (GspE-2) | / | 0.444 | |
| 1n2h | PAJ | Pantothenate synthetase | 6.3.2.1 | 0.443 | |
| 2gcg | NDP | Glyoxylate reductase/hydroxypyruvate reductase | 1.1.1.79 | 0.443 | |
| 3l63 | CAM | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 3lpg | Z78 | Beta-glucuronidase | 3.2.1.31 | 0.443 | |
| 3o03 | NAP | Dehydrogenase with different specificities (Related to short-chain alcohol dehydrogenase) | / | 0.443 | |
| 1jed | ADP | Sulfate adenylyltransferase | / | 0.442 | |
| 1toj | HCI | Aspartate aminotransferase | 2.6.1.1 | 0.442 | |
| 1zxn | ADP | DNA topoisomerase 2-alpha | 5.99.1.3 | 0.442 | |
| 2yj5 | ATP | Copper-transporting ATPase | / | 0.442 | |
| 3vqh | IQB | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.442 | |
| 4qxr | 1YE | Stimulator of interferon genes protein | / | 0.442 | |
| 1dap | NDP | Meso-diaminopimelate D-dehydrogenase | 1.4.1.16 | 0.441 | |
| 1joa | FAD | NADH peroxidase | 1.11.1.1 | 0.441 | |
| 2an9 | GDP | Guanylate kinase | 2.7.4.8 | 0.441 | |
| 3e2s | FAD | Bifunctional protein PutA | 1.5.5.2 | 0.441 | |
| 4hms | FMN | Phenazine biosynthesis protein PhzG | 1.4 | 0.441 | |
| 4lrl | TTP | HD domain protein | / | 0.441 | |
| 1zth | ADP | RIO-type serine/threonine-protein kinase Rio1 | 2.7.11.1 | 0.440 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.440 | |
| 2gnh | H52 | cAMP-dependent protein kinase catalytic subunit alpha | 2.7.11.11 | 0.440 | |
| 4jnk | NAI | L-lactate dehydrogenase A chain | 1.1.1.27 | 0.440 |