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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4o30SAHProbable Histone-lysine N-methyltransferase ATXR52.1.1.43

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4o30SAHProbable Histone-lysine N-methyltransferase ATXR52.1.1.431.000
5jinSAMHistone-lysine N-methyltransferase EHMT2/0.478
2o8jSAHHistone-lysine N-methyltransferase EHMT2/0.476
4ypuSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.472
3cbpSFGHistone-lysine N-methyltransferase SETD72.1.1.430.466
3kmtSAHHistone H3K27 methylase/0.466
3rsv3RSBeta-secretase 13.4.23.460.465
2h21SAMRibulose-1,5 bisphosphate carboxylase/oxygenase large subunit N-methyltransferase, chloroplastic2.1.1.1270.463
5ah5LSSLeucine--tRNA ligase/0.456
3n71SFGHistone-lysine N-methyltransferase Smyd1/0.455
1rfuADPPyridoxal kinase2.7.1.350.454
5jhnSAMHistone-lysine N-methyltransferase EHMT2/0.454
3ioeA7DPantothenate synthetase6.3.2.10.453
4ynmSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.453
2igqSAHHistone-lysine N-methyltransferase EHMT1/0.450
3tr05GPGuanylate kinase/0.450
5jj0SAMHistone-lysine N-methyltransferase EHMT2/0.450
3pdnSFGHistone-lysine N-methyltransferase SMYD32.1.1.430.449
5ao1DG3Deoxynucleoside triphosphate triphosphohydrolase SAMHD13.1.50.449
1amoFMNNADPH--cytochrome P450 reductase/0.447
3ribSAHN-lysine methyltransferase SMYD2/0.447
4ynpSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.447
1nupNMNNicotinamide/nicotinic acid mononucleotide adenylyltransferase 3/0.446
2g5w8PG12-oxophytodienoate reductase 31.3.1.420.444
4j83SAMHistone-lysine N-methyltransferase SETD72.1.1.430.444
2g1y5IGRenin3.4.23.150.443
4j4nD44Peptidylprolyl isomerase/0.443
2g226IGRenin3.4.23.150.442
2vf3GVS4-diphosphocytidyl-2-C-methyl-D-erythritol kinase/0.442
1kbo340NAD(P)H dehydrogenase [quinone] 11.6.5.20.441
2q1uNADPutative nucleotide sugar epimerase/ dehydratase/0.441
4ypaSAMHistone-lysine N-methyltransferase ASH1L2.1.1.430.441
3ivxFG6Pantothenate synthetase6.3.2.10.440