sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 4js9 | H4B | Nitric oxide synthase, inducible | 1.14.13.39 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 4js9 | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 1.000 | |
| 1qom | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.668 | |
| 1vaf | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.666 | |
| 1r35 | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.660 | |
| 3dwj | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.659 | |
| 3e6t | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.658 | |
| 1qw5 | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.655 | |
| 3e67 | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.654 | |
| 3e6o | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.653 | |
| 2nod | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.643 | |
| 1k2t | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.639 | |
| 4k5e | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.632 | |
| 3nlw | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.630 | |
| 4jsf | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.630 | |
| 3jt9 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.628 | |
| 3n5y | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.626 | |
| 4k5g | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.626 | |
| 3e7i | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.624 | |
| 4jsg | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.624 | |
| 4fvz | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.623 | |
| 3b3o | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.621 | |
| 3tyl | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.621 | |
| 4imt | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.621 | |
| 3rqm | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.620 | |
| 4ux6 | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.620 | |
| 3rqj | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.619 | |
| 4eux | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.619 | |
| 5agl | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.619 | |
| 3nw2 | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.617 | |
| 3tym | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.616 | |
| 3ufw | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.616 | |
| 1zzu | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.615 | |
| 3jwv | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.615 | |
| 3png | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.615 | |
| 3ufo | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.615 | |
| 3ej8 | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.613 | |
| 3pnf | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.612 | |
| 3svp | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.611 | |
| 4gqe | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.611 | |
| 4ug7 | H4B | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.611 | |
| 1k2u | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.610 | |
| 3jx2 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.610 | |
| 3nnz | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.610 | |
| 3ufr | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.610 | |
| 3e7g | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.609 | |
| 3jt5 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.609 | |
| 3nny | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.609 | |
| 3ufq | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.609 | |
| 3n5z | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.608 | |
| 3nlq | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.608 | |
| 3jwt | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.607 | |
| 3nlz | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.607 | |
| 3jt8 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.606 | |
| 3pne | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.606 | |
| 4k5d | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.606 | |
| 4lux | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.605 | |
| 3nlr | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.604 | |
| 3ufp | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.604 | |
| 4fvy | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.604 | |
| 3jx6 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.603 | |
| 1zzq | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.602 | |
| 2hx3 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.602 | |
| 1m8i | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.601 | |
| 3dqr | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.601 | |
| 4cx5 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.601 | |
| 3nlv | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.600 | |
| 1k2s | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.599 | |
| 3nlk | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.599 | |
| 3q9a | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.598 | |
| 4cx4 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.598 | |
| 1zzr | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.596 | |
| 3b3m | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.593 | |
| 3jt7 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.593 | |
| 4uga | H4B | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.593 | |
| 1dwx | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.592 | |
| 1m8d | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.592 | |
| 3jx3 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.592 | |
| 1p6j | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.591 | |
| 1m8e | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.590 | |
| 1p6k | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.590 | |
| 2hx4 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.590 | |
| 3jwu | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.589 | |
| 3nod | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.589 | |
| 3svq | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.589 | |
| 3b3p | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.587 | |
| 3fc5 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.587 | |
| 3rqk | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.587 | |
| 1m00 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.586 | |
| 3nlo | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.586 | |
| 3nly | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.586 | |
| 1m9t | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.585 | |
| 4fw0 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.584 | |
| 3ufu | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.583 | |
| 3ufv | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.583 | |
| 2g6i | HBI | Nitric oxide synthase, brain | 1.14.13.39 | 0.582 | |
| 2g6j | 7AP | Nitric oxide synthase, brain | 1.14.13.39 | 0.581 | |
| 4jsi | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.581 | |
| 3jta | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.580 | |
| 3nln | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.579 | |
| 1om5 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.578 | |
| 3nlp | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.578 | |
| 4fvx | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.578 | |
| 3nlj | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.577 | |
| 4cx3 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.577 | |
| 3jx4 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.576 | |
| 3rql | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.576 | |
| 3b3n | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.575 | |
| 4ug5 | H4B | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.575 | |
| 1rs6 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.571 | |
| 3hsn | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.571 | |
| 3jt6 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.571 | |
| 4imw | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.568 | |
| 3jx5 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.564 | |
| 5agp | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.558 | |
| 1mmv | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.557 | |
| 5agk | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.557 | |
| 3jt4 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.554 | |
| 3ufs | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.554 | |
| 3jt3 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.553 | |
| 3n5v | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.553 | |
| 1mjt | NAD | Nitric oxide synthase oxygenase | / | 0.552 | |
| 1rs7 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.552 | |
| 2y37 | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.550 | |
| 4jsh | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.550 | |
| 1zvl | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.548 | |
| 3q99 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.548 | |
| 4lwa | Q13 | Nitric oxide synthase oxygenase | 1.14.13.165 | 0.548 | |
| 1m8h | H4B | Nitric oxide synthase, inducible | 1.14.13.39 | 0.545 | |
| 3nos | H4B | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.544 | |
| 4d1o | H4B | Nitric oxide synthase, endothelial | 1.14.13.39 | 0.535 | |
| 4imu | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.519 | |
| 4jse | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.519 | |
| 3uft | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.518 | |
| 3af3 | GCP | Pantothenate kinase | 2.7.1.33 | 0.511 | |
| 2zsd | COA | Pantothenate kinase | 2.7.1.33 | 0.491 | |
| 2get | COK | Pantothenate kinase | 2.7.1.33 | 0.489 | |
| 4u0o | MTA | Lipoyl synthase 2 | / | 0.489 | |
| 3n61 | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.488 | |
| 4bfs | ZVS | Pantothenate kinase | 2.7.1.33 | 0.483 | |
| 2zse | ACP | Pantothenate kinase | 2.7.1.33 | 0.481 | |
| 3af4 | GCP | Pantothenate kinase | 2.7.1.33 | 0.481 | |
| 4k5f | H4B | Nitric oxide synthase, brain | 1.14.13.39 | 0.481 | |
| 2ges | COK | Pantothenate kinase | 2.7.1.33 | 0.477 | |
| 2geu | COK | Pantothenate kinase | 2.7.1.33 | 0.476 | |
| 5ah5 | LSS | Leucine--tRNA ligase | / | 0.472 | |
| 1zyd | ATP | eIF-2-alpha kinase GCN2 | / | 0.471 | |
| 1esm | COA | Pantothenate kinase | 2.7.1.33 | 0.468 | |
| 3aez | GDP | Pantothenate kinase | 2.7.1.33 | 0.466 | |
| 3hu2 | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.466 | |
| 3h4v | NAP | Pteridine reductase 1 | 1.5.1.33 | 0.454 | |
| 4kln | AGS | Transitional endoplasmic reticulum ATPase | 3.6.4.6 | 0.454 | |
| 2zsa | ADP | Pantothenate kinase | 2.7.1.33 | 0.449 | |
| 3af2 | ACP | Pantothenate kinase | 2.7.1.33 | 0.447 | |
| 3juq | AJD | Phenazine biosynthesis protein A/B | / | 0.447 | |
| 3rth | RTH | Beta-secretase 1 | 3.4.23.46 | 0.447 | |
| 4zme | ADN | Myosin heavy chain kinase A | 2.7.11.7 | 0.447 | |
| 1t0i | FMN | NAD(P)H-dependent FMN reductase LOT6 | / | 0.445 | |
| 2qcu | FAD | Aerobic glycerol-3-phosphate dehydrogenase | 1.1.5.3 | 0.445 | |
| 3wst | SAH | Protein arginine N-methyltransferase 7 | 2.1.1 | 0.445 | |
| 2zsb | ADP | Pantothenate kinase | 2.7.1.33 | 0.444 | |
| 4qx5 | CMP | cGMP-dependent protein kinase 1 | 2.7.11.12 | 0.444 | |
| 3af1 | GDP | Pantothenate kinase | 2.7.1.33 | 0.442 |