Logo scPDB

sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

Logo CNRS Logo Unistra
Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4j3mAJ8Tankyrase-22.4.2.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4j3mAJ8Tankyrase-22.4.2.301.000
4krs1SXTankyrase-12.4.2.300.602
4tkg09LTankyrase-22.4.2.300.575
3u9y09LTankyrase-22.4.2.300.573
4pnrG18Tankyrase-22.4.2.300.561
4hlm16STankyrase-22.4.2.300.549
4l091URTankyrase-22.4.2.300.539
4iueAJ4Tankyrase-22.4.2.300.537
4bj9UHBTankyrase-22.4.2.300.536
4hmhF94Tankyrase-22.4.2.300.530
4hkiFLNTankyrase-22.4.2.300.522
4li81XQTankyrase-12.4.2.300.520
4l33F70Tankyrase-22.4.2.300.512
4l2k1V8Tankyrase-22.4.2.300.510
4kzl20DTankyrase-22.4.2.300.509
4li71XPTankyrase-12.4.2.300.506
4j21AJ6Tankyrase-22.4.2.300.504
4hl515WTankyrase-22.4.2.300.503
4l0i1UWTankyrase-22.4.2.300.502
4avwG18Tankyrase-22.4.2.300.501
4j3lAJ5Tankyrase-22.4.2.300.501
4l0s1UZTankyrase-22.4.2.300.501
4l2f1V3Tankyrase-22.4.2.300.500
4buuF38Tankyrase-22.4.2.300.498
4buwF33Tankyrase-22.4.2.300.498
3kr8XAVTankyrase-22.4.2.300.497
4buiW2ETankyrase-22.4.2.300.496
4buxF35Tankyrase-22.4.2.300.493
2zitNADExotoxin A2.4.2.360.491
4buv16ITankyrase-22.4.2.300.490
4hlh20DTankyrase-22.4.2.300.490
4hlg20BTankyrase-22.4.2.300.486
5aku29FTankyrase-22.4.2.300.483
4avuLDRTankyrase-22.4.2.300.481
4bs4A64Tankyrase-22.4.2.300.481
3gwfNAPCyclohexanone monooxygenase/0.480
4msg2C6Tankyrase-12.4.2.300.480
4bjcRPBTankyrase-22.4.2.300.478
4bfvZVVPantothenate kinase2.7.1.330.476
4but31FTankyrase-22.4.2.300.474
4hlk431Tankyrase-22.4.2.300.473
3p0pNNFTankyrase-22.4.2.300.470
4l0v1V1Tankyrase-22.4.2.300.470
4i9i1DYTankyrase-12.4.2.300.469
4j22AJ7Tankyrase-22.4.2.300.469
4msk2C8Tankyrase-12.4.2.300.468
3zoiM2WIsopenicillin N synthase1.21.3.10.467
3b8hNADExotoxin A2.4.2.360.463
4mt92D6Tankyrase-12.4.2.300.463
4g2j0WFHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.462
4l321VFTankyrase-22.4.2.300.462
4tjy3GNTankyrase-22.4.2.300.462
1ps9MDE2,4-dienoyl-CoA reductase1.3.1.340.460
2fm5M99cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.460
3dylPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.460
3dyqPCGHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.459
4bus32FTankyrase-22.4.2.300.459
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.459
4qemHC4Phospholipase A2 VRV-PL-VIIIa/0.459
5c1mCLRMu-type opioid receptor/0.459
3zeiAWHO-acetylserine sulfhydrylase/0.458
2jb4A14Isopenicillin N synthase1.21.3.10.456
4gv4MEJPoly [ADP-ribose] polymerase 32.4.2.300.456
2v58LZJBiotin carboxylase6.3.4.140.455
4cax646Glycylpeptide N-tetradecanoyltransferase2.3.1.970.455
4gv7MEWPoly [ADP-ribose] polymerase 12.4.2.300.454
3dyqIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.452
3jsxCC2NAD(P)H dehydrogenase [quinone] 11.6.5.20.452
4gv25MEPoly [ADP-ribose] polymerase 32.4.2.300.452
1hb1OCVIsopenicillin N synthase1.21.3.10.451
1obnASVIsopenicillin N synthase1.21.3.10.451
2ejzSAHDiphthine synthase/0.451
1ex75GPGuanylate kinase2.7.4.80.450
3dysIBMHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.450
3exhTPPPyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial1.2.4.10.450
3exhTPPPyruvate dehydrogenase E1 component subunit beta, mitochondrial1.2.4.10.450
4bb3KKAIsopenicillin N synthase1.21.3.10.450
3h3qH13Collagen type IV alpha-3-binding protein/0.449
3zkuHCVIsopenicillin N synthase1.21.3.10.448
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.448
1itzTPPTransketolase, chloroplastic2.2.1.10.447
1jtvTESEstradiol 17-beta-dehydrogenase 11.1.1.620.446
2vqqTFGHistone deacetylase 43.5.1.980.446
3hmvHBTcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.446
3qe2FMNNADPH--cytochrome P450 reductase/0.446
3tr05GPGuanylate kinase/0.446
4n4t2GVTankyrase-12.4.2.300.446
2i65NADADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 13.2.2.60.445
2g8yNADHydroxycarboxylate dehydrogenase B/0.444
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.444
3b78NADExotoxin A2.4.2.360.444
4j7gTRHPCZA361.3/0.444
4uthFMNXenobiotic reductase/0.444
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.443
2bu9HFVIsopenicillin N synthase1.21.3.10.443
2r5nTPPTransketolase 1/0.443
2rd678PPoly [ADP-ribose] polymerase 12.4.2.300.443
2wo7ASVIsopenicillin N synthase1.21.3.10.443
3lq2TDPPyruvate dehydrogenase E1 component1.2.4.10.443
1bk0ACVIsopenicillin N synthase1.21.3.10.442
2yp0OVE2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.442
3dc3AZMCarbonic anhydrase 24.2.1.10.442
3g70A5TRenin3.4.23.150.442
4hhy15RPoly [ADP-ribose] polymerase 12.4.2.300.442
2zs8ADPPantothenate kinase2.7.1.330.441
3ce0P34Poly [ADP-ribose] polymerase 32.4.2.300.441
3g86T18Genome polyprotein2.7.7.480.441
3hl0NADMaleylacetate reductase/0.441
4h3f10OBeta-secretase 13.4.23.460.440
5irnADPNucleotide binding oligomerization domain containing 2/0.440