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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4hseADPChaperone protein ClpB

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4hseADPChaperone protein ClpB/1.000
3d8bADPFidgetin-like protein 13.6.40.478
4fd2ADPChaperone protein ClpB/0.478
2bl4NADLactaldehyde reductase1.1.1.770.474
1e94ANPATP-dependent protease ATPase subunit HslU/0.473
4fcwADPChaperone protein ClpB/0.473
4hjfC2EGGDEF family protein/0.472
3qlfPD5Proto-oncogene tyrosine-protein kinase Src2.7.10.20.464
1nr5NADPentafunctional AROM polypeptide/0.463
1glfADPGlycerol kinase/0.459
3oibFDAPutative acyl-CoA dehydrogenase/0.459
1qvrANPChaperone protein ClpB/0.458
2b52D42Cyclin-dependent kinase 22.7.11.220.456
2yw2ATPPhosphoribosylamine--glycine ligase/0.456
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.456
1im2ADPATP-dependent protease ATPase subunit HslU/0.455
2z7qACPRibosomal protein S6 kinase alpha-12.7.11.10.455
3q4zANPSerine/threonine-protein kinase PAK 12.7.11.10.455
4y8wSTRSteroid 21-hydroxylase/0.455
1d4hBEHGag-Pol polyprotein3.4.23.160.454
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.454
2ykjYKJHeat shock protein HSP 90-alpha/0.452
3cgdNADCoenzyme A disulfide reductase/0.452
5br7FADUDP-galactopyranose mutase/0.452
1c6yMK1Protease/0.451
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.451
1nqoNADGlyceraldehyde-3-phosphate dehydrogenase/0.450
3ea4FABAcetolactate synthase, chloroplastic2.2.1.60.450
3qw2NADMyo-inositol-1-phosphate synthase (Ino1)/0.450
1me8RVPInosine-5'-monophosphate dehydrogenase/0.449
3wv9FEGHmd co-occurring protein HcgE/0.449
1qvnFRIInterleukin-2/0.448
2vrx447Aurora kinase B-A2.7.11.10.448
3dzdADPTranscriptional regulator (NtrC family)/0.448
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.448
3rf7NADIron-containing alcohol dehydrogenase/0.447
4eiyZMAAdenosine receptor A2a/0.447
4ly91YYGlucokinase regulatory protein/0.447
2b9wFADPutative aminooxidase/0.446
2yyiFAD4-hydroxyphenylacetate 3-monooxygenase oxygenase component1.14.14.90.446
3b2w9NHTyrosine-protein kinase Lck2.7.10.20.446
4y9qC2EUncharacterized protein/0.446
3pcrGTPADP-ribosylation factor 6/0.445
1f0xFADD-lactate dehydrogenase1.1.1.280.444
1p31EPUUDP-N-acetylmuramate--L-alanine ligase6.3.2.80.443
2ykeYKEHeat shock protein HSP 90-alpha/0.443
2z4sADPChromosomal replication initiator protein DnaA/0.443
3ql6NIMLactoperoxidase1.11.1.70.443
5fm7ADPRuvB-like helicase/0.443
1rrmAPRLactaldehyde reductase1.1.1.770.442
2hw1ANPKetohexokinase/0.442
2z3uCRRCytochrome P450/0.442
4jv618FRetinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta/0.442
4kin1M8Mitogen-activated protein kinase 14/0.442
1szmBI4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
2x19GTPGTP-binding nuclear protein GSP1/CNR1/0.441
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.441
3ruqADPChaperonin/0.441
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.441
4l2iFADElectron transfer flavoprotein alpha/beta-subunit/0.441
1kzkJE2Gag-Pol polyprotein3.4.23.160.440
2j0lANPFocal adhesion kinase 12.7.10.20.440
4lj9ACPChaperone protein ClpB/0.440