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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4hgl0YOCasein kinase I isoform gamma-32.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4hgl0YOCasein kinase I isoform gamma-32.7.11.11.000
4g160VMCasein kinase I isoform gamma-32.7.11.10.694
2izrBRKCasein kinase I isoform gamma-32.7.11.10.638
4g170VNCasein kinase I isoform gamma-32.7.11.10.577
4hgs15GCasein kinase I isoform gamma-32.7.11.10.569
2izsBRQCasein kinase I isoform gamma-32.7.11.10.550
2izt23DCasein kinase I isoform gamma-32.7.11.10.541
2chlDKICasein kinase I isoform gamma-32.7.11.10.491
2izuP01Casein kinase I isoform gamma-32.7.11.10.480
1eh4IC1Casein kinase I homolog 12.7.11.10.476
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.474
4hgt15GCasein kinase I isoform delta2.7.11.10.473
2c475IDCasein kinase I isoform gamma-2/0.471
4kbk1QGCasein kinase I isoform delta2.7.11.10.467
2nruT12Interleukin-1 receptor-associated kinase 42.7.11.10.465
4mq12C3Dual specificity tyrosine-phosphorylation-regulated kinase 1A2.7.12.10.460
4d0l093Phosphatidylinositol 4-kinase beta2.7.1.670.456
3gc9B45Mitogen-activated protein kinase 112.7.11.240.453
1gih1PUCyclin-dependent kinase 22.7.11.220.452
1xddAAYIntegrin alpha-L/0.452
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.452
3gubGUBDeath-associated protein kinase 12.7.11.10.452
3mtfA3FActivin receptor type-12.7.11.300.452
1k6pXN3Gag-Pol polyprotein3.4.23.160.450
2cmwOLPCasein kinase I isoform gamma-12.7.11.10.449
3t8oATPRhodopsin kinase/0.449
4kikKSAInhibitor of nuclear factor kappa-B kinase subunit beta2.7.11.100.449
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.448
3abaFLICytochrome P450/0.447
4k1b1OCSerine/threonine-protein kinase pim-12.7.11.10.447
3ambVX6cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.445
3ekp478Gag-Pol polyprotein3.4.23.160.445
4j5j478Gag-Pol polyprotein3.4.23.160.445
3uyt0CKCasein kinase I isoform delta2.7.11.10.444
4ic7ANPMitogen-activated protein kinase 72.7.11.240.444
4wboANWRhodopsin kinase/0.444
2yirYIRSerine/threonine-protein kinase Chk22.7.11.10.443
3lltANPProtein serine/threonine kinase-1/0.443
1di8DTQCyclin-dependent kinase 22.7.11.220.442
3c4zADPRhodopsin kinase/0.442
4c4jX21Dual specificity protein kinase TTK2.7.12.10.442
1xjdSTUProtein kinase C theta type2.7.11.130.441
2objVRVSerine/threonine-protein kinase pim-12.7.11.10.441
2yitYITSerine/threonine-protein kinase Chk22.7.11.10.441
4oj4DIFPeroxisome proliferator-activated receptor gamma/0.441
2fleAIProtease/0.440
4ez50RSCyclin-dependent kinase 62.7.11.220.440