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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4go2TAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.6

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4go2TAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.61.000
4itbNDPSuccinate-semialdehyde dehydrogenase/0.540
2wmeNAPNAD/NADP-dependent betaine aldehyde dehydrogenase/0.501
4nmjNAPAldehyde dehydrogenase/0.499
3hazNADBifunctional protein PutA/0.494
2ehqNAP1-pyrroline-5-carboxylate dehydrogenase/0.490
3rhhNAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase/0.487
1wnbNAIGamma-aminobutyraldehyde dehydrogenase1.2.1.190.484
3iwkNADAminoaldehyde dehydrogenase/0.484
4fqfNADAldehyde dehydrogenase, mitochondrial1.2.1.30.484
3lv1NAPNAD(P)-dependent benzaldehyde dehydrogenase1.2.1.280.483
2j40NAD1-pyrroline-5-carboxylate dehydrogenase/0.482
1nzzNAIAldehyde dehydrogenase, mitochondrial1.2.1.30.480
3lnsNAPNAD(P)-dependent benzaldehyde dehydrogenase1.2.1.280.479
2o2qNAPCytosolic 10-formyltetrahydrofolate dehydrogenase1.5.1.60.478
4fr8NADAldehyde dehydrogenase, mitochondrial1.2.1.30.476
3v9lNADDelta-1-pyrroline-5-carboxylate dehydrogenase, mitochondrial1.2.1.880.475
4pz2NADAldehyde dehydrogenase 2-6/0.475
1uxnNAPNAD(P)-dependent glyceraldehyde-3-phosphate dehydrogenase/0.471
3n82NADAldehyde dehydrogenase, mitochondrial1.2.1.30.470
3n83ADPAldehyde dehydrogenase, mitochondrial1.2.1.30.470
2eiiNAD1-pyrroline-5-carboxylate dehydrogenase/0.469
2onpNADAldehyde dehydrogenase, mitochondrial1.2.1.30.467
2j5nNAD1-pyrroline-5-carboxylate dehydrogenase/0.466
1o00NADAldehyde dehydrogenase, mitochondrial1.2.1.30.465
2esdNAPNADP-dependent glyceraldehyde-3-phosphate dehydrogenase1.2.1.90.464
4x4lNAIRetinal dehydrogenase 11.2.1.360.463
2bhpNAD1-pyrroline-5-carboxylate dehydrogenase/0.461
2onmNADAldehyde dehydrogenase, mitochondrial1.2.1.30.458
4i1wNAD2-aminomuconate 6-semialdehyde dehydrogenase/0.457
1o02NADAldehyde dehydrogenase, mitochondrial1.2.1.30.456
4nmkNAPAldehyde dehydrogenase/0.454
1ad3NADAldehyde dehydrogenase, dimeric NADP-preferring/0.453
4h73NDPAldehyde dehydrogenase/0.453
2y5dNAP3,4-dehydroadipyl-CoA semialdehyde dehydrogenase/0.451
4pxlNADAldehyde dehydrogenase3/0.450
3ju8NADN-succinylglutamate 5-semialdehyde dehydrogenase1.2.1.710.449
5eyuNADBetaine-aldehyde dehydrogenase/0.448
2jg7NADAntiquitin/0.446
4v37NADBetaine aldehyde dehydrogenase, chloroplastic1.2.1.80.445
1nzxNADAldehyde dehydrogenase, mitochondrial1.2.1.30.444
1o01NADAldehyde dehydrogenase, mitochondrial1.2.1.30.441