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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4g5dNDPProstaglandin F synthase1.1.1.188

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4g5dNDPProstaglandin F synthase1.1.1.1881.000
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.597
1az2NAPAldose reductase1.1.1.210.572
2iq0NAPAldose reductase1.1.1.210.572
2acqNAPAldose reductase1.1.1.210.563
2j8tNAPAldose reductase1.1.1.210.562
1x96NAPAldose reductase1.1.1.210.550
2pfhNDPAldose reductase1.1.1.210.546
3v36NAPAldose reductase1.1.1.210.542
4pmjNAPPutative oxidoreductase/0.541
1x98NAPAldose reductase1.1.1.210.538
3h7rNAPAldo-keto reductase family 4 member C8/0.535
3qkzNAPAldose reductase-related protein 11.1.1.210.535
2acsNAPAldose reductase1.1.1.210.531
3q65NAPAldose reductase1.1.1.210.530
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.529
1ah4NAPAldose reductase1.1.1.210.527
1c9wNAPAldose reductase-related protein 2/0.525
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.522
1vp5NAPOxidoreductase, aldo/keto reductase family/0.516
1adsNAPAldose reductase1.1.1.210.511
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.510
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.509
1r38NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.508
1z8aNAPAldose reductase1.1.1.210.507
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.507
3q67NAPAldose reductase1.1.1.210.507
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.505
1zgdNAPChalcone reductase/0.500
2pf8NDPAldose reductase1.1.1.210.498
2pevNDPAldose reductase1.1.1.210.496
4xo7NAPAldo-keto reductase family 1 member C2/0.496
1mi3NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.494
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.494
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.492
4jtqNAPAldo-keto reductase family 1 member C2/0.492
1a80NDP2,5-diketo-D-gluconic acid reductase A1.1.1.3460.491
1og6NAPOxidoreductase YdhF10.488
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.487
2hejNDPAldo-keto reductase family 1 member C211.1.10.483
2acuNAPAldose reductase1.1.1.210.481
3wczNAPAldo-keto reductase AKR2E4/0.479
4jq3NAPAldo-keto reductase family 1 member C2/0.476
2bgsNDPAldose reductase1.1.1.210.475
1ye6NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.472
2hdjNDPAldo-keto reductase family 1 member C2/0.472
1s1rNAPAldo-keto reductase family 1 member C3/0.471
1ye6NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.470
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.469
5c7hNDPPutative oxidoreductase/0.469
4ijrNDPD-arabinose dehydrogenase [NAD(P)+] heavy chain1.1.1.1170.466
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.465
3o3rNAPAldose reductase-related protein 11.1.1.210.465
4jtcNAPVoltage-gated potassium channel subunit beta-2/0.465
4aubNAPL-glyceraldehyde 3-phosphate reductase1.1.10.461
4dz5NAPAldo-keto reductase family 1 member C3/0.460
2clpNDPAflatoxin B1 aldehyde reductase member 3/0.459
1lqaNDPProtein tas/0.457
3lnmNAPVoltage-gated potassium channel subunit beta-2/0.456
1z9aNADNAD(P)H-dependent D-xylose reductase1.1.1.3070.454
1hqtNAPAlcohol dehydrogenase [NADP(+)]1.1.1.20.451
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.451
4l1xNAPAldo-keto reductase family 1 member C2/0.451
1pz1NAPGeneral stress protein 69/0.447
4jtaNAPVoltage-gated potassium channel subunit beta-2/0.447
4xzmNAPAldo-keto reductase family 1 member B101.1.10.444
4jtdNAPVoltage-gated potassium channel subunit beta-2/0.442
4xznNAPAldo-keto reductase family 1 member B101.1.10.441