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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fv5EK9Mitogen-activated protein kinase 12.7.11.24

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fv5EK9Mitogen-activated protein kinase 12.7.11.241.000
3i5zZ48Mitogen-activated protein kinase 12.7.11.240.635
4fv6E57Mitogen-activated protein kinase 12.7.11.240.603
3i60E86Mitogen-activated protein kinase 12.7.11.240.601
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.537
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.529
4fv3EK6Mitogen-activated protein kinase 12.7.11.240.522
4qnyANPMitogen activated protein kinase, putative/0.505
4btjATPTau-tubulin kinase 12.7.11.10.494
1j1bANPGlycogen synthase kinase-3 beta2.7.11.260.493
4btjADPTau-tubulin kinase 12.7.11.10.487
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.486
5e8ySTUTGF-beta receptor type-22.7.11.300.484
2b9iADPMitogen-activated protein kinase FUS32.7.11.240.483
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.481
4fv1EK4Mitogen-activated protein kinase 12.7.11.240.479
1qmzATPCyclin-dependent kinase 22.7.11.220.475
2ojj82AMitogen-activated protein kinase 12.7.11.240.475
4h3qANPMitogen-activated protein kinase 12.7.11.240.473
3nieANPMitogen-activated protein kinase/0.470
4ii5ADPCyclin-dependent kinase 22.7.11.220.467
2uzbC75Cyclin-dependent kinase 22.7.11.220.464
4aqc88ATyrosine-protein kinase JAK2/0.464
5dnrATPAurora kinase A2.7.11.10.463
2uzwSS4cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.462
4e6d0NUTyrosine-protein kinase JAK2/0.462
5dosATPAurora kinase A2.7.11.10.462
2yaaATPDeath-associated protein kinase 2/0.461
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.461
3qcx3Q23-phosphoinositide-dependent protein kinase 12.7.11.10.460
4aguD15Cyclin-dependent kinase-like 1/0.460
4j95ACPFibroblast growth factor receptor 2/0.458
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.457
3zc6VFCTyrosine-protein kinase JAK32.7.10.20.456
4eooATPCyclin-dependent kinase 22.7.11.220.456
5ap7SVEDual specificity protein kinase TTK2.7.12.10.455
4nifANPMitogen-activated protein kinase 12.7.11.240.454
4deeADPAurora kinase A2.7.11.10.452
3lltANPProtein serine/threonine kinase-1/0.451
4ic7ANPMitogen-activated protein kinase 72.7.11.240.451
4oh4ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.451
2b9jADPMitogen-activated protein kinase FUS32.7.11.240.450
2j0lANPFocal adhesion kinase 12.7.10.20.450
4fr4STUSerine/threonine-protein kinase 32A2.7.11.10.450
4yhjAN2G protein-coupled receptor kinase 42.7.11.160.450
4bl1ANPMaternal embryonic leucine zipper kinase2.7.11.10.449
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.449
4hge15VTyrosine-protein kinase JAK2/0.449
4qmlANPSerine/threonine-protein kinase 242.7.11.10.449
4l7f1V5Mitogen-activated protein kinase 82.7.11.240.448
3gu7ADPDeath-associated protein kinase 12.7.11.10.447
1pmn984Mitogen-activated protein kinase 102.7.11.240.446
3iok1P6Tyrosine-protein kinase JAK2/0.446
3r2b05BMAP kinase-activated protein kinase 22.7.11.10.446
3s1h56ZCyclin-dependent kinase 22.7.11.220.446
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.446
4i5cC5ITyrosine-protein kinase JAK1/0.446
5e92ANPTGF-beta receptor type-22.7.11.300.446
3dfcANPDeath-associated protein kinase 12.7.11.10.444
3f69XDRSerine/threonine-protein kinase PknB2.7.11.10.444
4jia1K3Tyrosine-protein kinase JAK2/0.444
4ux9ANPMitogen-activated protein kinase 82.7.11.240.444
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.444
2ijmATPFocal adhesion kinase 12.7.10.20.443
2j0m4STFocal adhesion kinase 12.7.10.20.443
2vo7M05cAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.443
3lpbNVBTyrosine-protein kinase JAK2/0.442
2xckMH43-phosphoinositide-dependent protein kinase 12.7.11.10.441
4s33ANPMitogen-activated protein kinase 12.7.11.240.441
4c3pACPAurora kinase A2.7.11.10.440
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.440