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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fr10V2Queuine tRNA-ribosyltransferase2.4.2.29

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fr10V2Queuine tRNA-ribosyltransferase2.4.2.291.000
4giy0WYQueuine tRNA-ribosyltransferase2.4.2.290.748
1y5vNE8Queuine tRNA-ribosyltransferase2.4.2.290.589
3ge7AFQQueuine tRNA-ribosyltransferase2.4.2.290.589
4gh30EVQueuine tRNA-ribosyltransferase2.4.2.290.587
4gh10WXQueuine tRNA-ribosyltransferase2.4.2.290.576
4gi40EXQueuine tRNA-ribosyltransferase2.4.2.290.572
4fps0UXQueuine tRNA-ribosyltransferase2.4.2.290.567
4gg90WWQueuine tRNA-ribosyltransferase2.4.2.290.564
1y5wNEZQueuine tRNA-ribosyltransferase2.4.2.290.545
3sm0AEKQueuine tRNA-ribosyltransferase2.4.2.290.538
4fsa0V3Queuine tRNA-ribosyltransferase2.4.2.290.538
4gkt0O1Queuine tRNA-ribosyltransferase2.4.2.290.538
1y5xE89Queuine tRNA-ribosyltransferase2.4.2.290.535
1q63AIQQueuine tRNA-ribosyltransferase2.4.2.290.534
1q66KMBQueuine tRNA-ribosyltransferase2.4.2.290.520
4q8pCKRQueuine tRNA-ribosyltransferase2.4.2.290.520
3gc4AAQQueuine tRNA-ribosyltransferase2.4.2.290.519
2qzrS79Queuine tRNA-ribosyltransferase2.4.2.290.481
1q65BHBQueuine tRNA-ribosyltransferase2.4.2.290.479
2bbf344Queuine tRNA-ribosyltransferase2.4.2.290.471
3tdaPN0Cytochrome P450 2D6/0.471
3cow52HPantothenate synthetase6.3.2.10.469
3akzGSUGlutamate--tRNA ligase 2/0.466
2g28TDKPyruvate dehydrogenase E1 component1.2.4.10.465
1k4hAPQQueuine tRNA-ribosyltransferase2.4.2.290.463
4f1yCNIGlutamate receptor 3/0.463
2c94TSF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.462
2ivpATPtRNA N6-adenosine threonylcarbamoyltransferase/0.461
2z1wBDIQueuine tRNA-ribosyltransferase2.4.2.290.461
1k4gAIQQueuine tRNA-ribosyltransferase2.4.2.290.459
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
1efyBZCPoly [ADP-ribose] polymerase 12.4.2.300.455
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.455
4bb6HD1Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.455
4h1e10JBeta-secretase 13.4.23.460.454
3b7dCNIGlutamate receptor 2/0.451
1uhoVDNcGMP-specific 3',5'-cyclic phosphodiesterase/0.450
4fvz4KJNitric oxide synthase, brain1.14.13.390.449
1r6uTYMTryptophan--tRNA ligase, cytoplasmic6.1.1.20.446
4gki0JNAminoglycoside 3'-phosphotransferase AphA1-IAB/0.446
1w7h3IPMitogen-activated protein kinase 14/0.444
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.444
2qtaTDPPyruvate dehydrogenase E1 component1.2.4.10.444
3to3ATPPetrobactin biosynthesis protein AsbB/0.444
1hv9UD1Bifunctional protein GlmU/0.443
2in6839Wee1-like protein kinase2.7.10.20.443
3rsv3RSBeta-secretase 13.4.23.460.443
3rthRTHBeta-secretase 13.4.23.460.443
4wx2F6FTryptophan synthase alpha chain/0.443
4wx2F6FTryptophan synthase beta chain4.2.1.200.443
2a4xBLMMitomycin-binding protein/0.442
2po7CHDFerrochelatase, mitochondrial4.99.1.10.442
3isjA8DPantothenate synthetase6.3.2.10.442
3udj092Beta-secretase 13.4.23.460.442
3vv8B02Beta-secretase 13.4.23.460.442
4b78KGGBeta-secretase 13.4.23.460.442
4cdmFADDeoxyribodipyrimidine photolyase/0.442
1sguMK1Gag-Pol polyprotein3.4.23.160.441
1w19T4P6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.441
2qnqQN3Gag-Pol polyprotein3.4.23.160.441
3oq13OQCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
3rviRVIBeta-secretase 13.4.23.460.441
3vweCOAAlpha-tubulin N-acetyltransferase 1/0.441
3pblETQD(3) dopamine receptor/0.441
4gmgNAPYersiniabactin biosynthetic protein YbtU/0.440
4tvj09LPoly [ADP-ribose] polymerase 22.4.2.300.440