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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fqsLYAThymidylate synthase ThyA

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fqsLYAThymidylate synthase ThyA/1.000
2ftoCB3Thymidylate synthase/0.661
4gevCB3Thymidylate synthase/0.625
4knzCB3Thymidylate synthase/0.565
4isk1JYThymidylate synthase/0.557
1kceCB3Thymidylate synthase/0.548
1tysDHFThymidylate synthase/0.546
1dnaCB3Thymidylate synthase/0.545
1nceCB3Thymidylate synthase/0.532
1jtuLYBThymidylate synthase/0.529
1jtqLY3Thymidylate synthase/0.527
3k2hLYABifunctional dihydrofolate reductase-thymidylate synthase/0.523
1kziTHGThymidylate synthase/0.518
3bgxMEFThymidylate synthase/0.516
2bbqPFGThymidylate synthase/0.513
2aazCB3Thymidylate synthase2.1.1.450.512
1f4fTP3Thymidylate synthase/0.511
1fwmCB3Thymidylate synthase/0.510
1trgCB3Thymidylate synthase/0.509
1aiqCB3Thymidylate synthase/0.507
1hvyD16Thymidylate synthase2.1.1.450.506
4ez8DHFThymidylate synthase2.1.1.450.505
3bhrTHGThymidylate synthase/0.500
3uwlFOZThymidylate synthase/0.498
1zprCB3Thymidylate synthase/0.494
1ju6LYAThymidylate synthase2.1.1.450.492
1axwMTXThymidylate synthase/0.485
4fogC2FThymidylate synthase ThyA/0.473
1kzjCB3Thymidylate synthase/0.472
1dduCB3Thymidylate synthase/0.469
1f28F89Thymidylate synthase2.1.1.450.467
2kceD16Thymidylate synthase/0.467
3bhlTHGThymidylate synthase/0.464
1qzfCB3Bifunctional dihydrofolate reductase-thymidylate synthase/0.461
3q43D66M1 family aminopeptidase3.4.110.458
4o7uTHFThymidylate synthase/0.457
1fxsNAPGDP-L-fucose synthase/0.451
1tduCB3Thymidylate synthase/0.451
4ejmNAPPutative zinc-binding dehydrogenase/0.451
1f4gTP4Thymidylate synthase/0.450
2tscCB3Thymidylate synthase/0.450
5eaiFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.450
1d4aFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1an5CB3Thymidylate synthase/0.448
4irnFADAnaB/0.448
1jutLYDThymidylate synthase/0.447
3q44D50M1 family aminopeptidase3.4.110.447
4ge40KEKynurenine/alpha-aminoadipate aminotransferase, mitochondrial2.6.1.390.447
1jujLYAThymidylate synthase2.1.1.450.446
1bq1CB3Thymidylate synthase/0.444
2pg0FADAcyl-CoA dehydrogenase/0.444
4h8aNAIUreidoglycolate dehydrogenase (NAD(+))1.1.1.3500.444
2ok7FADFerredoxin--NADP reductase, apicoplast/0.442
1oc1ASVIsopenicillin N synthase1.21.3.10.441
3toxNAPPutative oxidoreductase/0.441
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.441
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.440
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.440