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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4fl2ANPTyrosine-protein kinase SYK2.7.10.2

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4fl2ANPTyrosine-protein kinase SYK2.7.10.21.000
4fl3ANPTyrosine-protein kinase SYK2.7.10.20.607
4k2rANPTyrosine-protein kinase ZAP-702.7.10.20.544
2ozoANPTyrosine-protein kinase ZAP-702.7.10.20.515
5cnnANPEpidermal growth factor receptor2.7.10.10.496
1hckATPCyclin-dependent kinase 22.7.11.220.472
3orpAGSSerine/threonine protein kinase/0.472
5cnoANPEpidermal growth factor receptor2.7.10.10.471
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.470
3vn9ANKDual specificity mitogen-activated protein kinase kinase 62.7.12.20.464
3ortAGSSerine/threonine protein kinase/0.462
3c4zADPRhodopsin kinase/0.461
3orkAGSSerine/threonine protein kinase/0.461
4awiAQ2Mitogen-activated protein kinase 82.7.11.240.461
3plsANPMacrophage-stimulating protein receptor2.7.10.10.458
4zseANPEpidermal growth factor receptor2.7.10.10.456
3ormAGSSerine/threonine protein kinase/0.455
1dayGNPCasein kinase II subunit alpha2.7.11.10.454
4k33ACPFibroblast growth factor receptor 32.7.10.10.454
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.453
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.452
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.452
1b38ATPCyclin-dependent kinase 22.7.11.220.451
3bu5ATPInsulin receptor2.7.10.10.451
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.450
2bxnIDBSerum albumin/0.450
4fg9ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.450
3nynSGVG protein-coupled receptor kinase 62.7.11.160.449
5dnrATPAurora kinase A2.7.11.10.449
1b39ATPCyclin-dependent kinase 22.7.11.220.447
4anmWULCasein kinase II subunit alpha2.7.11.10.446
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.444
1jnkANPMitogen-activated protein kinase 102.7.11.240.443
1i44ACPInsulin receptor2.7.10.10.442
1dawANPCasein kinase II subunit alpha2.7.11.10.441
3oroAGSSerine/threonine protein kinase/0.441
4iayADPcAMP-dependent protein kinase catalytic subunit alpha2.7.11.110.441
4lrjANPUncharacterized protein/0.441
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.440
3cgfJNFMitogen-activated protein kinase 102.7.11.240.440
4j95ACPFibroblast growth factor receptor 2/0.440
4qnyANPMitogen activated protein kinase, putative/0.440