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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.9

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4dquNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.91.000
2nv6ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.622
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.602
2ntvP1HEnoyl-[acyl-carrier-protein] reductase [NADH]/0.593
2aqiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.580
1enyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.579
2ie0ZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.575
3of2NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.574
2aqhNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.573
1zidZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.565
2idzZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.561
2aqkNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.560
4dreNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.559
2iebZIDEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.554
3oewNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.546
5cpbNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.543
3oeyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.534
2ntjP1HEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.532
4dtiNAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.524
1enzNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.522
2aq8NAIEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.520
4zjuNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.519
4trnNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.517
2h9iEADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.516
1bvrNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.512
4bqpNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.503
4biiPYWEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.492
4rlh0WEEnoyl-[acyl-carrier-protein] reductase [NADH]/0.492
4fw8NAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.489
3uicNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.488
1g6kNADGlucose 1-dehydrogenase1.1.1.470.482
2d1yNADOxidoreductase, short-chain dehydrogenase/reductase family/0.481
4oxyNADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.478
4dc0NDPPutative ketoacyl reductase1.3.10.477
1bwsNDPGDP-L-fucose synthase/0.469
2b37NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.466
2b36NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.462
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.462
3lqfNADGalactitol dehydrogenase/0.461
4dbzNDPPutative ketoacyl reductase1.3.10.459
4m87NADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.459
2vcmM11Isopenicillin N synthase1.21.3.10.457
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.456
3hk1B64Fatty acid-binding protein, adipocyte/0.455
4nbtNAD3-oxoacyl-[acyl-carrier-protein] reductase/0.453
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.452
3vt8YI3Vitamin D3 receptor/0.452
1zmcNADDihydrolipoyl dehydrogenase, mitochondrial1.8.1.40.451
4bb3KKAIsopenicillin N synthase1.21.3.10.451
1bk0ACVIsopenicillin N synthase1.21.3.10.450
2b35NADEnoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.450
3p3zP3ZPutative cytochrome P450/0.450
1oc1ASVIsopenicillin N synthase1.21.3.10.449
1qbgFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1u7tNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.448
5koiNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.448
2vn0TDZCytochrome P450 2C8/0.447
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.447
1rwbNADGlucose 1-dehydrogenase1.1.1.470.444
1blzACVIsopenicillin N synthase1.21.3.10.443
1dbvNADGlyceraldehyde-3-phosphate dehydrogenase/0.443
1dhiMTXDihydrofolate reductase1.5.1.30.443
1wntNAPL-xylulose reductase1.1.1.100.443
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.442
4q73FADBifunctional protein PutA/0.442
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.441
1hb1OCVIsopenicillin N synthase1.21.3.10.441
1jioDEB6-deoxyerythronolide B hydroxylase/0.441
2c29NAPDihydroflavonol 4-reductase/0.441
4q72FADBifunctional protein PutA/0.441
1dhjMTXDihydrofolate reductase1.5.1.30.440
2bd0NAPSepiapterin reductase/0.440
2jb4A14Isopenicillin N synthase1.21.3.10.440
3zkyWT4Isopenicillin N synthase1.21.3.10.440
4hp8NAP2-deoxy-D-gluconate 3-dehydrogenase/0.440