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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4d86ADPPoly [ADP-ribose] polymerase 142.4.2.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4d86ADPPoly [ADP-ribose] polymerase 142.4.2.301.000
3q71AR6Poly [ADP-ribose] polymerase 142.4.2.300.652
3vfqAR6Poly [ADP-ribose] polymerase 142.4.2.300.595
2bfqAR6[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.483
1kbqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.475
2bfrADP[Protein ADP-ribosylglutamate] hydrolase AF_15213.2.20.472
4xrgNADHomospermidine synthase2.5.1.440.470
4iarERM5-hydroxytryptamine receptor 1B/0.464
1xkvATPPhosphoenolpyruvate carboxykinase (ATP)/0.463
1dxqFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.459
5cmsAPRO-acetyl-ADP-ribose deacetylase/0.459
1osvCHCBile acid receptor/0.456
2c0cNAPProstaglandin reductase 310.456
2cmjNAPIsocitrate dehydrogenase [NADP] cytoplasmic1.1.1.420.456
3v2bAR6Poly [ADP-ribose] polymerase 152.4.2.300.456
4b1iA8PPoly(ADP-ribose) glycohydrolase3.2.1.1430.456
4lx9ACON-alpha-acetyltransferase2.3.10.453
4uwmFMN3,6-diketocamphane 1,6 monooxygenase1.14.130.453
2ebaFADPutative glutaryl-CoA dehydrogenase/0.452
2fhnBNIAvidin-related protein 4/5/0.451
2y05NAPProstaglandin reductase 1/0.451
1nytNAPShikimate dehydrogenase (NADP(+))/0.450
3r7kFDAProbable acyl CoA dehydrogenase/0.450
1kboFADNAD(P)H dehydrogenase [quinone] 11.6.5.20.449
1n1eNDEGlycerol-3-phosphate dehydrogenase [NAD(+)], glycosomal1.1.1.80.449
3iidAPRCore histone macro-H2A.1/0.449
4a312CBGlycylpeptide N-tetradecanoyltransferase/0.449
4xq9NADHomospermidine synthase2.5.1.440.449
1e3eNAIAlcohol dehydrogenase 41.1.1.10.448
1gg5FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.448
1hwzNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.448
1mp0NADAlcohol dehydrogenase class-31.1.1.10.448
1xq6NAPUncharacterized protein At5g02240/0.448
3b70NAPEnoyl reductase LovC10.448
5dp2NAPCurF/0.448
5lc1NADL-threonine 3-dehydrogenase/0.448
1pr9NAPL-xylulose reductase1.1.1.100.447
2fzwNADAlcohol dehydrogenase class-31.1.1.10.447
3siiA1RUncharacterized protein/0.447
3qwbNDPProbable quinone oxidoreductase1.6.5.50.446
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.446
4fdnFADDecaprenylphosphoryl-beta-D-ribose oxidase/0.446
1tehNADAlcohol dehydrogenase class-31.1.1.10.445
3vdqNAD3-hydroxybutyrate dehydrogenase/0.445
4wuoNAD3-isopropylmalate dehydrogenase1.1.1.850.445
4yagNAIC alpha-dehydrogenase/0.445
1i2bNADUDP-sulfoquinovose synthase, chloroplastic3.13.1.10.444
4tvbNADHomospermidine synthase2.5.1.440.444
5a3bAPRSIR2 family protein/0.444
5cb5APRO-acetyl-ADP-ribose deacetylase/0.444
1h66FADNAD(P)H dehydrogenase [quinone] 11.6.5.20.443
2wyvNADEnoyl-[acyl-carrier-protein] reductase [NADH]/0.443
3etdNDPGlutamate dehydrogenase 1, mitochondrial1.4.1.30.443
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.443
4qi5FADCellobiose dehydrogenase/0.442
2givACOHistone acetyltransferase KAT8/0.441
2zb3NDPProstaglandin reductase 21.3.1.480.441
3iifAPRCore histone macro-H2A.1/0.441
3k4cFADPyranose 2-oxidase/0.440
3qlsNDPDihydrofolate reductase1.5.1.30.440