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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4bueJQFTankyrase-22.4.2.30

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4bueJQFTankyrase-22.4.2.301.000
4buxF35Tankyrase-22.4.2.300.792
4l0t1V0Tankyrase-22.4.2.300.779
4l2g1V4Tankyrase-22.4.2.300.762
4buwF33Tankyrase-22.4.2.300.747
4hlh20DTankyrase-22.4.2.300.724
4bus32FTankyrase-22.4.2.300.722
4bs4A64Tankyrase-22.4.2.300.718
4l341VGTankyrase-22.4.2.300.676
4hlf15ZTankyrase-22.4.2.300.660
3kr8XAVTankyrase-22.4.2.300.651
4l321VFTankyrase-22.4.2.300.648
4l0i1UWTankyrase-22.4.2.300.643
4iueAJ4Tankyrase-22.4.2.300.642
4l31F08Tankyrase-22.4.2.300.642
4bu908CTankyrase-22.4.2.300.636
4buuF38Tankyrase-22.4.2.300.633
4l0s1UZTankyrase-22.4.2.300.630
4kzuA73Tankyrase-22.4.2.300.622
4bufF36Tankyrase-22.4.2.300.621
4kzl20DTankyrase-22.4.2.300.620
4buiW2ETankyrase-22.4.2.300.616
4l10A63Tankyrase-22.4.2.300.615
4hlk431Tankyrase-22.4.2.300.612
4but31FTankyrase-22.4.2.300.611
4l2f1V3Tankyrase-22.4.2.300.610
5aku29FTankyrase-22.4.2.300.609
4j22AJ7Tankyrase-22.4.2.300.608
4hkkAGITankyrase-22.4.2.300.607
4l33F70Tankyrase-22.4.2.300.603
4hlm16STankyrase-22.4.2.300.600
4bud29FTankyrase-22.4.2.300.598
4hl515WTankyrase-22.4.2.300.597
3p0pNNFTankyrase-22.4.2.300.595
4l2k1V8Tankyrase-22.4.2.300.595
4j21AJ6Tankyrase-22.4.2.300.592
4l0v1V1Tankyrase-22.4.2.300.592
4bj9UHBTankyrase-22.4.2.300.589
4avwG18Tankyrase-22.4.2.300.587
4hknLU2Tankyrase-22.4.2.300.582
4tkg09LTankyrase-22.4.2.300.576
4hlg20BTankyrase-22.4.2.300.569
4hmhF94Tankyrase-22.4.2.300.564
4krs1SXTankyrase-12.4.2.300.549
4pnrG18Tankyrase-22.4.2.300.542
4hkiFLNTankyrase-22.4.2.300.531
4bjbP34Tankyrase-22.4.2.300.524
4msk2C8Tankyrase-12.4.2.300.516
4l091URTankyrase-22.4.2.300.507
4pnmNU1Tankyrase-22.4.2.300.506
4buv16ITankyrase-22.4.2.300.502
4avuLDRTankyrase-22.4.2.300.472
4j3lAJ5Tankyrase-22.4.2.300.469
3rsv3RSBeta-secretase 13.4.23.460.464
4gv08MEPoly [ADP-ribose] polymerase 32.4.2.300.455
3tqcADPPantothenate kinase/0.454
1i5rHYCEstradiol 17-beta-dehydrogenase 11.1.1.620.453
4tjy3GNTankyrase-22.4.2.300.453
4hyf1AKTankyrase-22.4.2.300.452
3k5fAYHBeta-secretase 13.4.23.460.447
1paxDHQPoly [ADP-ribose] polymerase 12.4.2.300.445
1xs7MMIBeta-secretase 13.4.23.460.442
3g4gD71cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.442
4epq0RRPoly(ADP-ribose) glycohydrolase/0.441
3c49KU8Poly [ADP-ribose] polymerase 32.4.2.300.440
4b1hAR6Poly(ADP-ribose) glycohydrolase3.2.1.1430.440