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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
4bmvNAPShort-chain dehydrogenase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
4bmvNAPShort-chain dehydrogenase/1.000
4j7uNAPSepiapterin reductase1.1.1.1530.562
4hwkNAPSepiapterin reductase1.1.1.1530.561
4j7xNAPSepiapterin reductase1.1.1.1530.556
1xg5NAPDehydrogenase/reductase SDR family member 11/0.531
2yutNAPPutative short-chain oxidoreductase/0.530
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.514
1ae1NAPTropinone reductase 1/0.512
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.511
1ipeNDPTropinone reductase 21.1.1.2360.509
1snyNAPLD36273p/0.509
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/0.508
2jahNDPClavaldehyde dehydrogenase/0.507
1xkqNDPUncharacterized protein/0.505
5idwNAPShort-chain dehydrogenase/reductase SDR/0.503
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.502
3l77NJPShort-chain alcohol dehydrogenase/0.500
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.498
3gy0NAPNAD(P)-dependent oxidoreductase/0.496
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.494
1oaaNAPSepiapterin reductase1.1.1.1530.491
3toxNAPPutative oxidoreductase/0.491
1x7gNAPPutative ketoacyl reductase1.3.10.488
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.486
1w4zNAPPutative ketoacyl reductase1.3.10.482
1fduNAPEstradiol 17-beta-dehydrogenase 11.1.1.620.481
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.481
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.480
3sjuNDPKeto reductase/0.479
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.479
3p19NDPPutative blue fluorescent protein/0.478
1n5dNDPCarbonyl reductase [NADPH] 1/0.475
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.474
4dc1NDPPutative ketoacyl reductase1.3.10.473
3qrwNDPPutative ketoacyl reductase1.3.10.472
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.471
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.470
4esoNAPPutative oxidoreductase/0.469
3ai2NDPNADPH-sorbose reductase/0.468
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.468
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.467
1pr9NAPL-xylulose reductase1.1.1.100.466
1x7hNDPPutative ketoacyl reductase1.3.10.466
1wntNAPL-xylulose reductase1.1.1.100.465
3tn7NJPShort-chain alcohol dehydrogenase/0.465
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.464
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.460
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.459
3w8eNAD3-hydroxybutyrate dehydrogenase/0.457
1g6kNADGlucose 1-dehydrogenase1.1.1.470.456
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.455
4qecNAPElxO/0.455
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.453
3u4cNDPNADPH-dependent reductase BacG/0.450
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.450
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.449
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.448
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.448
2bd0NAPSepiapterin reductase/0.447
3ai3NDPNADPH-sorbose reductase/0.447
3vdqNAD3-hydroxybutyrate dehydrogenase/0.447
4o0lNDPNADPH-dependent 3-quinuclidinone reductase/0.444
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.444
1n7gNDPGDP-mannose 4,6 dehydratase 24.2.1.470.442
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.440
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.440
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.440
4dmmNAP3-oxoacyl-[acyl-carrier-protein] reductase/0.440