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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3zxtACPDeath-associated protein kinase 12.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3zxtACPDeath-associated protein kinase 12.7.11.11.000
3gu7ADPDeath-associated protein kinase 12.7.11.10.512
2w4jADPDeath-associated protein kinase 12.7.11.10.510
1ig1ANPDeath-associated protein kinase 12.7.11.10.504
5eg3ACPFibroblast growth factor receptor 2/0.495
1jklANPDeath-associated protein kinase 12.7.11.10.492
1jkkANPDeath-associated protein kinase 12.7.11.10.489
2yaaATPDeath-associated protein kinase 2/0.482
3bu5ATPInsulin receptor2.7.10.10.480
3c4wATPRhodopsin kinase/0.476
3qd03Q43-phosphoinositide-dependent protein kinase 12.7.11.10.475
4qnyANPMitogen activated protein kinase, putative/0.474
5dosATPAurora kinase A2.7.11.10.474
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.468
1j1cADPGlycogen synthase kinase-3 beta2.7.11.260.464
4xlvACPInsulin receptor2.7.10.10.463
3qd43Q63-phosphoinositide-dependent protein kinase 12.7.11.10.461
4ysjADPCalmodulin-like domain protein kinase/0.461
4i3zADPCyclin-dependent kinase 22.7.11.220.459
3qc9ADPRhodopsin kinase/0.458
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.456
1mruAGSSerine/threonine-protein kinase PknB2.7.11.10.455
3ictCOACoenzyme A disulfide reductase/0.453
1xr1ANPSerine/threonine-protein kinase pim-12.7.11.10.451
4eooATPCyclin-dependent kinase 22.7.11.220.451
2ycqUPXSerine/threonine-protein kinase Chk22.7.11.10.447
2ycrHCWSerine/threonine-protein kinase Chk22.7.11.10.447
4bbfO19Tyrosine-protein kinase JAK2/0.446
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.446
5av2KMPDeath-associated protein kinase 12.7.11.10.443
2j0m4STFocal adhesion kinase 12.7.10.20.441
3icrCOACoenzyme A disulfide reductase/0.441
3t2zFADSulfide-quinone reductase/0.441
5dnrATPAurora kinase A2.7.11.10.441
1zp9ATPRIO-type serine/threonine-protein kinase Rio12.7.11.10.440
3c4xATPRhodopsin kinase/0.440
4hvi19STyrosine-protein kinase JAK32.7.10.20.440
5av3KMPDeath-associated protein kinase 12.7.11.10.440