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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3v36NAPAldose reductase1.1.1.21

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3v36NAPAldose reductase1.1.1.211.000
1x96NAPAldose reductase1.1.1.210.652
3q65NAPAldose reductase1.1.1.210.649
2iq0NAPAldose reductase1.1.1.210.645
1z8aNAPAldose reductase1.1.1.210.636
2acqNAPAldose reductase1.1.1.210.634
3q67NAPAldose reductase1.1.1.210.633
1x98NAPAldose reductase1.1.1.210.632
2pfhNDPAldose reductase1.1.1.210.625
1adsNAPAldose reductase1.1.1.210.605
1az2NAPAldose reductase1.1.1.210.596
2pevNDPAldose reductase1.1.1.210.595
2j8tNAPAldose reductase1.1.1.210.594
1ah4NAPAldose reductase1.1.1.210.589
2pf8NDPAldose reductase1.1.1.210.588
2acsNAPAldose reductase1.1.1.210.586
2acuNAPAldose reductase1.1.1.210.560
3o3rNAPAldose reductase-related protein 11.1.1.210.556
3h7uNAPNADPH-dependent aldo-keto reductase, chloroplastic/0.548
4pmjNAPPutative oxidoreductase/0.544
3h7rNAPAldo-keto reductase family 4 member C8/0.542
4g5dNDPProstaglandin F synthase1.1.1.1880.539
3qkzNAPAldose reductase-related protein 11.1.1.210.538
1k8cNAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.535
1c9wNAPAldose reductase-related protein 2/0.526
3uzwNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.521
2hejNDPAldo-keto reductase family 1 member C211.1.10.520
3g1rNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.515
1q5mNDPProstaglandin-E(2) 9-reductase1.1.1.1890.512
1r38NAPNAD(P)H-dependent D-xylose reductase1.1.1.3070.506
1s1rNAPAldo-keto reductase family 1 member C3/0.503
4jtcNAPVoltage-gated potassium channel subunit beta-2/0.503
3buvNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.501
3wbwNDPPutative 2,5-diketo-D-gluconic acid reductase/0.501
1zgdNAPChalcone reductase/0.499
2hdjNDPAldo-keto reductase family 1 member C2/0.495
1lqaNDPProtein tas/0.491
1ye6NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.491
4dz5NAPAldo-keto reductase family 1 member C3/0.491
2fvlNAPAldo-keto reductase family 1 member C41.1.1.2250.488
1ef3NAPAldose reductase1.1.1.210.487
1vp5NAPOxidoreductase, aldo/keto reductase family/0.486
1mi3NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.480
2r9rNAPVoltage-gated potassium channel subunit beta-2/0.478
3caqNDP3-oxo-5-beta-steroid 4-dehydrogenase/0.476
4aubNAPL-glyceraldehyde 3-phosphate reductase1.1.10.474
4xo7NAPAldo-keto reductase family 1 member C2/0.474
3wczNAPAldo-keto reductase AKR2E4/0.473
1sm9NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.465
1ye4NADNAD(P)H-dependent D-xylose reductase1.1.1.3070.465
3dopNAP3-oxo-5-beta-steroid 4-dehydrogenase/0.464
3wg6NDPNADPH-dependent conjugated polyketone reductase C1/0.463
2vdgNDPAldose reductase1.1.1.210.461
4jtqNAPAldo-keto reductase family 1 member C2/0.461
5c7hNDPPutative oxidoreductase/0.461
4l1xNAPAldo-keto reductase family 1 member C2/0.460
3lnmNAPVoltage-gated potassium channel subunit beta-2/0.459
4jq3NAPAldo-keto reductase family 1 member C2/0.459
1z9aNADNAD(P)H-dependent D-xylose reductase1.1.1.3070.458
4xzmNAPAldo-keto reductase family 1 member B101.1.10.457
2p5nNDPAldo-keto reductase family 1 member C211.1.10.455
4ijrNDPD-arabinose dehydrogenase [NAD(P)+] heavy chain1.1.1.1170.454
1og6NAPOxidoreductase YdhF10.452
1pz1NAPGeneral stress protein 69/0.450
3bv7NAP3-oxo-5-beta-steroid 4-dehydrogenase/0.444
4jtdNAPVoltage-gated potassium channel subunit beta-2/0.444
1lwiNAP3-alpha-hydroxysteroid dehydrogenase1.1.1.500.441