sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3uon | QNB | Muscarinic acetylcholine receptor M2 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3uon | QNB | Muscarinic acetylcholine receptor M2 | / | 1.000 | |
| 4u14 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.582 | |
| 4u15 | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.551 | |
| 4daj | 0HK | Muscarinic acetylcholine receptor M3 | / | 0.506 | |
| 4u16 | 3C0 | Muscarinic acetylcholine receptor M3 | / | 0.497 | |
| 2xuq | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.481 | |
| 2xuo | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.471 | |
| 3uzz | TES | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.469 | |
| 2ckm | AA7 | Acetylcholinesterase | 3.1.1.7 | 0.467 | |
| 4f1l | 0RY | Poly [ADP-ribose] polymerase 14 | 2.4.2.30 | 0.465 | |
| 3qe2 | FMN | NADPH--cytochrome P450 reductase | / | 0.461 | |
| 4n82 | FMN | Ribonucleotide reductase (NrdI family protein), putative | / | 0.461 | |
| 4a31 | 2CB | Glycylpeptide N-tetradecanoyltransferase | / | 0.458 | |
| 4dbs | 0HV | Aldo-keto reductase family 1 member C3 | / | 0.456 | |
| 3n3z | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.455 | |
| 2xuf | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.453 | |
| 1ry0 | PG2 | Aldo-keto reductase family 1 member C3 | / | 0.449 | |
| 2aov | C2M | Histamine N-methyltransferase | 2.1.1.8 | 0.448 | |
| 3aiv | HBO | 4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic | 3.2.1.182 | 0.448 | |
| 3dyq | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.448 | |
| 3uzx | AOX | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.448 | |
| 2jf0 | HBP | Acetylcholinesterase | 3.1.1.7 | 0.446 | |
| 4b12 | C23 | Glycylpeptide N-tetradecanoyltransferase | / | 0.445 | |
| 1kyv | RBF | 6,7-dimethyl-8-ribityllumazine synthase | 2.5.1.78 | 0.444 | |
| 1q83 | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.444 | |
| 3cot | STR | 3-oxo-5-beta-steroid 4-dehydrogenase | / | 0.444 | |
| 3dy8 | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.444 | |
| 1fml | RTL | Retinol dehydratase | / | 0.443 | |
| 2xug | TZ4 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 2xuk | TZ5 | Acetylcholinesterase | 3.1.1.7 | 0.443 | |
| 4g2j | 0WF | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.443 | |
| 4q0k | GA3 | Phytohormone-binding protein | / | 0.443 | |
| 5dsy | UHB | Poly [ADP-ribose] polymerase 2 | 2.4.2.30 | 0.442 | |
| 3dyl | IBM | High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A | / | 0.441 | |
| 2bn4 | FMN | NADPH--cytochrome P450 reductase | / | 0.440 | |
| 2wsa | 646 | Glycylpeptide N-tetradecanoyltransferase | / | 0.440 | |
| 2xys | SY9 | Soluble acetylcholine receptor | / | 0.440 | |
| 4mrm | 2BY | Gamma-aminobutyric acid type B receptor subunit 1 | / | 0.440 | |
| 5dsg | 0HK | Muscarinic acetylcholine receptor M4 | / | 0.440 |