sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3ums | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3ums | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 1.000 | |
| 4pan | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.566 | |
| 4pao | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.533 | |
| 4fid | GDP | G protein alpha subunit, putative | / | 0.518 | |
| 1gia | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.515 | |
| 1y3a | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.510 | |
| 1gil | GSP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.508 | |
| 1got | GDP | Guanine nucleotide-binding protein G(t) subunit alpha-1 | / | 0.506 | |
| 3c15 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.492 | |
| 3c14 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.482 | |
| 3vhx | GTP | ADP-ribosylation factor 6 | / | 0.478 | |
| 2xtz | GSP | Guanine nucleotide-binding protein alpha-1 subunit | / | 0.477 | |
| 3c16 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.477 | |
| 3qe0 | GDP | Guanine nucleotide-binding protein G(i) subunit alpha-1 | / | 0.477 | |
| 3tjz | GNP | ADP-ribosylation factor 1 | / | 0.475 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.473 | |
| 5fm7 | ADP | RuvB-like helicase | / | 0.468 | |
| 2giv | ACO | Histone acetyltransferase KAT8 | / | 0.467 | |
| 1azt | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.464 | |
| 1mja | COA | Histone acetyltransferase ESA1 | / | 0.464 | |
| 2fe4 | GDP | Ras-related protein Rab-6B | / | 0.462 | |
| 2dvl | FAD | Acyl-CoA dehydrogenase | / | 0.461 | |
| 1u0h | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.459 | |
| 2ou2 | ACO | Histone acetyltransferase KAT5 | / | 0.457 | |
| 2y05 | NAP | Prostaglandin reductase 1 | / | 0.457 | |
| 2gvd | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.456 | |
| 4o2r | GDP | GTP-binding protein Rheb | / | 0.456 | |
| 1qo8 | FAD | Fumarate reductase flavoprotein subunit | / | 0.455 | |
| 2ehu | NAD | 1-pyrroline-5-carboxylate dehydrogenase | / | 0.454 | |
| 5fl3 | ADP | Pili retraction protein PilT | / | 0.454 | |
| 2y0m | ACO | Histone acetyltransferase KAT8 | / | 0.453 | |
| 1ma0 | NAD | Alcohol dehydrogenase class-3 | 1.1.1.1 | 0.452 | |
| 3mpi | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.452 | |
| 3b6z | CO7 | Enoyl reductase LovC | 1 | 0.451 | |
| 3cib | 314 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 1cs4 | GSP | Guanine nucleotide-binding protein G(s) subunit alpha isoforms short | / | 0.450 | |
| 3pcr | GTP | ADP-ribosylation factor 6 | / | 0.450 | |
| 5l3r | GCP | Cell division protein FtsY homolog, chloroplastic | / | 0.450 | |
| 2ivn | ANP | tRNA N6-adenosine threonylcarbamoyltransferase | / | 0.449 | |
| 1mjb | ACO | Histone acetyltransferase ESA1 | / | 0.448 | |
| 1xdd | AAY | Integrin alpha-L | / | 0.448 | |
| 3gqv | NAP | Enoyl reductase LovC | 1 | 0.448 | |
| 3k4n | FAD | Pyranose 2-oxidase | / | 0.448 | |
| 1llu | NAD | Alcohol dehydrogenase | / | 0.447 | |
| 3cx6 | GDP | Guanine nucleotide-binding protein subunit alpha-13 | / | 0.447 | |
| 3lqf | NAD | Galactitol dehydrogenase | / | 0.447 | |
| 3i7e | DJR | Gag-Pol polyprotein | / | 0.445 | |
| 3w32 | W32 | Epidermal growth factor receptor | 2.7.10.1 | 0.445 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.445 | |
| 5env | NAD | Alcohol dehydrogenase 1 | 1.1.1.1 | 0.445 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 1zd9 | GDP | ADP-ribosylation factor-like protein 8A | / | 0.444 | |
| 5br7 | FAD | UDP-galactopyranose mutase | / | 0.444 | |
| 1c6y | MK1 | Protease | / | 0.443 | |
| 3phi | NDP | Shikimate dehydrogenase (NADP(+)) | / | 0.443 | |
| 3r7w | GNP | GTP-binding protein GTR2 | / | 0.443 | |
| 3mjh | GTP | Ras-related protein Rab-5A | / | 0.442 | |
| 1qlh | NAD | Alcohol dehydrogenase E chain | 1.1.1.1 | 0.441 | |
| 2ch6 | ADP | N-acetyl-D-glucosamine kinase | 2.7.1.59 | 0.441 | |
| 3kb1 | ADP | Iron-sulfur cluster carrier protein | / | 0.441 | |
| 4dfg | 0JV | Gag-Pol polyprotein | 3.4.23.16 | 0.441 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.440 | |
| 2nru | T12 | Interleukin-1 receptor-associated kinase 4 | 2.7.11.1 | 0.440 | |
| 2p83 | MR0 | Beta-secretase 1 | 3.4.23.46 | 0.440 | |
| 2rcy | NAP | Pyrroline-5-carboxylate reductase | / | 0.440 | |
| 3cis | ATP | Universal stress protein Rv2623 | / | 0.440 | |
| 3mpj | FAD | Glutaryl-CoA dehydrogenase | 1.3.99.32 | 0.440 |