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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3smaACOFrbF

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3smaACOFrbF/1.000
3mpiFADGlutaryl-CoA dehydrogenase1.3.99.320.486
3juoAJDPhenazine biosynthesis protein A/B/0.482
1x31FMNSubunit alpha of sarocosine oxidase/0.475
1x31FMNSubunit beta of sarcosine oxidase/0.475
2q0dATPPoly(A) polymerase, putative/0.473
3junAJDPhenazine biosynthesis protein A/B/0.472
3juqAJDPhenazine biosynthesis protein A/B/0.470
4ihqADPConserved Archaeal protein/0.467
1p9wANPType II secretion system protein E/0.463
3ijwACOAminoglycoside N3-acetyltransferase/0.456
3dzl3OCPhenazine biosynthesis protein A/B/0.455
4zo3C6LAcylhomoserine lactonase/0.455
1jmiUMPThymidylate synthase/0.454
2dvlFADAcyl-CoA dehydrogenase/0.453
3sqxANPATP-dependent RNA helicase MSS116, mitochondrial3.6.4.130.452
4fh5UTPTerminal uridylyltransferase cid1/0.452
2c9zQUEAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.451
2nomDUTPoly(A) polymerase, putative/0.451
4fxy0W2Neurolysin, mitochondrial3.4.24.160.451
1nb6UTPGenome polyprotein2.7.7.480.450
1o6i0HZChitinase B3.2.1.140.449
1foaUD1Alpha-1,3-mannosyl-glycoprotein 2-beta-N-acetylglucosaminyltransferase2.4.1.1010.447
2e93B29Geranylgeranyl pyrophosphate synthase/0.447
4g3pUD1Bifunctional protein GlmU/0.447
3koyZ97D-ornithine 4,5-aminomutase subunit beta/0.446
5ayzNCNNicotinate-nucleotide pyrophosphorylase [carboxylating]2.4.2.190.446
3zecANPAdenosine monophosphate-protein transferase SoFic2.7.7.n10.445
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.444
3e8xNAPBH1520 protein/0.444
1jzqILAIsoleucine--tRNA ligase6.1.1.50.443
1r8bATPCCA-adding enzyme2.7.7.720.443
2nm2NEUDihydroneopterin aldolase/0.443
1t1rIMB1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.442
1y5xE89Queuine tRNA-ribosyltransferase2.4.2.290.441
2zsaADPPantothenate kinase2.7.1.330.441
3apwDP0Alpha-1-acid glycoprotein 2/0.441
2vatCOAAcetyl-CoA--deacetylcephalosporin C acetyltransferase2.3.1.1750.440