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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3r8gIZPAldo-keto reductase family 1 member C3

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3r8gIZPAldo-keto reductase family 1 member C3/1.000
4h7c10HAldo-keto reductase family 1 member C3/0.767
3uweVJJAldo-keto reductase family 1 member C3/0.715
4fa30SLAldo-keto reductase family 1 member C3/0.692
3r6iJMSAldo-keto reductase family 1 member C3/0.666
3r94FLRAldo-keto reductase family 1 member C3/0.666
1s2cFLFAldo-keto reductase family 1 member C3/0.665
3r7mSUZAldo-keto reductase family 1 member C3/0.664
3r43ID8Aldo-keto reductase family 1 member C3/0.644
4fal0T0Aldo-keto reductase family 1 member C3/0.639
4dbw511Aldo-keto reductase family 1 member C3/0.626
1ry0PG2Aldo-keto reductase family 1 member C3/0.623
3r8hZOMAldo-keto reductase family 1 member C3/0.621
1zq5E04Aldo-keto reductase family 1 member C3/0.615
4hmn16JAldo-keto reductase family 1 member C3/0.605
3r58NPSAldo-keto reductase family 1 member C3/0.598
4dbuBT9Aldo-keto reductase family 1 member C3/0.597
3ugrIMNAldo-keto reductase family 1 member C3/0.591
4fam0SZAldo-keto reductase family 1 member C3/0.585
3ug8IMNAldo-keto reductase family 1 member C3/0.579
3ufyNPXAldo-keto reductase family 1 member C3/0.576
4dbs0HVAldo-keto reductase family 1 member C3/0.562
1ry8RUTAldo-keto reductase family 1 member C3/0.557
2f3815MAldo-keto reductase family 1 member C3/0.548
1xf0ASDAldo-keto reductase family 1 member C3/0.482
3iakEV1cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.480
3aiqHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase 1b, chloroplastic3.2.1.1820.477
3b9oFMNAlkane monoxygenase/0.476
1q83TZ5Acetylcholinesterase3.1.1.70.472
2vz0D64Pteridine reductase/0.468
2ouu35GcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.466
4eilFOLBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.465
1y2k7DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.463
4n9qFMNFMN-dependent NADH-azoreductase 1/0.459
3aivHBO4-hydroxy-7-methoxy-3-oxo-3,4-dihydro-2H-1,4-benzoxazin-2-yl glucoside beta-D-glucosidase, chloroplastic3.2.1.1820.457
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
2gyuHI6Acetylcholinesterase3.1.1.70.455
2rds1PL1-deoxypentalenic acid 11-beta-hydroxylase1.14.11.350.454
3f3y4OABile salt sulfotransferase2.8.2.140.454
3v0o4GWHisto-blood group ABO system transferase/0.454
3v94WYQPhosphodiesterase/0.454
1zg32HIIsoflavone 4'-O-methyltransferase/0.453
3sfy3FYUncharacterized protein/0.452
3nwlNDPCatalase1.11.1.60.451
4bbhYBNGlycylpeptide N-tetradecanoyltransferase/0.451
4jtqFLPAldo-keto reductase family 1 member C2/0.451
4ky404JBifunctional dihydrofolate reductase-thymidylate synthase1.5.1.30.451
2c1zKMPAnthocyanidin 3-O-glucosyltransferase 22.4.1.1150.450
2xuiTZ5Acetylcholinesterase3.1.1.70.450
3ghvGHCDihydrofolate reductase1.5.1.30.450
1xomCIOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.449
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.448
4b117I1Glycylpeptide N-tetradecanoyltransferase/0.448
4hcy0YNTransketolase/0.448
1xonPILcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
2xukTZ5Acetylcholinesterase3.1.1.70.447
2xuoTZ4Acetylcholinesterase3.1.1.70.447
3k4s0MOcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.447
3qe2FMNNADPH--cytochrome P450 reductase/0.447
2yhuWHFPteridine reductase/0.446
3sl8JN7cAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.445
3wavDWVEctonucleotide pyrophosphatase/phosphodiesterase family member 23.1.4.390.444
1ut6A8NAcetylcholinesterase3.1.1.70.443
1y2bDEEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.443
2aovC2MHistamine N-methyltransferase2.1.1.80.443
2xuhTZ4Acetylcholinesterase3.1.1.70.443
2xupTZ5Acetylcholinesterase3.1.1.70.443
4f1l0RYPoly [ADP-ribose] polymerase 142.4.2.300.443
4jq2SUZAldo-keto reductase family 1 member C2/0.443
1odcA8BAcetylcholinesterase3.1.1.70.442
2jl1NAPTriphenylmethane reductase/0.442
3fvuIACKynurenine--oxoglutarate transaminase 12.6.1.70.442
3g72A6TRenin3.4.23.150.442
4hf415HcAMP and cAMP-inhibited cGMP 3',5'-cyclic phosphodiesterase 10A3.1.4.170.442
4hutATPCob(I)yrinic acid a,c-diamide adenosyltransferase2.5.1.170.442
4kp61S1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.442
4x3uSVRChromobox protein homolog 7/0.442
1o6qR17Squalene--hopene cyclase4.2.1.1290.441
1uhjCZBAequorin-2/0.441
1w6jR71Lanosterol synthase5.4.99.70.441
2g274LGRenin3.4.23.150.441
4bftZVTPantothenate kinase2.7.1.330.441
5c1mCLRMu-type opioid receptor/0.441
1nsgRADPeptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.440
1nsgRADSerine/threonine-protein kinase mTOR2.7.11.10.440
1tcoFK5Peptidyl-prolyl cis-trans isomerase FKBP1A5.2.1.80.440
1tcoFK5Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform3.1.3.160.440
1zgcA2EAcetylcholinesterase3.1.1.70.440