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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3orpAGSSerine/threonine protein kinase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3orpAGSSerine/threonine protein kinase/1.000
3ortAGSSerine/threonine protein kinase/0.530
3gu7ADPDeath-associated protein kinase 12.7.11.10.482
3p23ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.473
1ig1ANPDeath-associated protein kinase 12.7.11.10.469
2xrwANPMitogen-activated protein kinase 82.7.11.240.468
3oriAGSSerine/threonine protein kinase/0.463
1jkkANPDeath-associated protein kinase 12.7.11.10.460
3kvxFMYMitogen-activated protein kinase 102.7.11.240.459
4pl4ADPSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.459
3oroAGSSerine/threonine protein kinase/0.458
5eg3ACPFibroblast growth factor receptor 2/0.458
3lltANPProtein serine/threonine kinase-1/0.457
4fg8ATPCalcium/calmodulin-dependent protein kinase type 12.7.11.170.457
2yaaATPDeath-associated protein kinase 2/0.453
3bu5ATPInsulin receptor2.7.10.10.452
3ormAGSSerine/threonine protein kinase/0.452
4qnyANPMitogen activated protein kinase, putative/0.452
3c4zADPRhodopsin kinase/0.451
4bfmANPMaternal embryonic leucine zipper kinase2.7.11.10.450
1i44ACPInsulin receptor2.7.10.10.446
1jklANPDeath-associated protein kinase 12.7.11.10.445
2w4jADPDeath-associated protein kinase 12.7.11.10.443
3c4wATPRhodopsin kinase/0.443
4fv2EK5Mitogen-activated protein kinase 12.7.11.240.443
5dosATPAurora kinase A2.7.11.10.441
3dqwAGSProto-oncogene tyrosine-protein kinase Src2.7.10.20.440