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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3nn6HNK6-hydroxy-L-nicotine oxidase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3nn6HNK6-hydroxy-L-nicotine oxidase/1.000
2yg4FADPutrescine oxidase/0.561
3k7mFAD6-hydroxy-L-nicotine oxidase/0.536
1bk0ACVIsopenicillin N synthase1.21.3.10.502
3zkyWT4Isopenicillin N synthase1.21.3.10.498
2iviACWIsopenicillin N synthase1.21.3.10.494
1obnASVIsopenicillin N synthase1.21.3.10.493
2jb4A14Isopenicillin N synthase1.21.3.10.491
2yg3FADPutrescine oxidase/0.491
4bb3KKAIsopenicillin N synthase1.21.3.10.491
1uzwCDHIsopenicillin N synthase1.21.3.10.479
3zoiM2WIsopenicillin N synthase1.21.3.10.479
2bu9HFVIsopenicillin N synthase1.21.3.10.477
2y60M8FIsopenicillin N synthase1.21.3.10.477
2vbdV10Isopenicillin N synthase1.21.3.10.474
1qiqACCIsopenicillin N synthase1.21.3.10.472
2vbpVB1Isopenicillin N synthase1.21.3.10.471
1qjfACSIsopenicillin N synthase1.21.3.10.468
1pkfEPDEpothilone C/D epoxidase1.140.467
1hb3SCVIsopenicillin N synthase1.21.3.10.466
2yg5FADPutrescine oxidase/0.465
1hb1OCVIsopenicillin N synthase1.21.3.10.464
1mkdZARcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.457
2vvlFADMonoamine oxidase N1.4.3.40.457
1fvpFMANon-fluorescent flavoprotein/0.456
1y2c3DEcAMP-specific 3',5'-cyclic phosphodiesterase 4D3.1.4.530.455
1oc1ASVIsopenicillin N synthase1.21.3.10.454
2hkoFADLysine-specific histone demethylase 1A10.453
3fr4F8AFatty acid-binding protein, adipocyte/0.453
3w5eNVWcAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.453
4aosNAPSteroid monooxygenase/0.453
5hbrCOAAcyl-CoA synthetase (NDP forming)/0.453
1h83FADPolyamine oxidase1.5.3.140.452
3ghvGHCDihydrofolate reductase1.5.1.30.451
3gjwGJWPoly [ADP-ribose] polymerase 12.4.2.300.451
3qeoLLTDeoxycytidine kinase2.7.1.740.450
1pq944BOxysterols receptor LXR-beta/0.449
4psbGA3Cytokinin-specific binding protein/0.449
5c6cCMPcGMP-dependent protein kinase 22.7.11.120.449
2vcmM11Isopenicillin N synthase1.21.3.10.448
4a30QMIGlycylpeptide N-tetradecanoyltransferase/0.448
1blzACVIsopenicillin N synthase1.21.3.10.446
1r2jFADFkbI/0.446
1sd2MTHS-methyl-5'-thioadenosine phosphorylase/0.446
2b82ADNClass B acid phosphatase3.1.3.20.446
4b13X25Glycylpeptide N-tetradecanoyltransferase/0.446
2a58RBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.445
2y6fM9FIsopenicillin N synthase1.21.3.10.445
2wo7ASVIsopenicillin N synthase1.21.3.10.444
1q5dEPBEpothilone C/D epoxidase1.140.443
1w06W05Isopenicillin N synthase1.21.3.10.443
3ssnMVIMycinamicin VI 2''-O-methyltransferase/0.443
2xysSY9Soluble acetylcholine receptor/0.442
3otwCOAPhosphopantetheine adenylyltransferase/0.442
1kyvRBF6,7-dimethyl-8-ribityllumazine synthase2.5.1.780.441
2uxoTACHTH-type transcriptional regulator TtgR/0.441
3jsiWTCHigh affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A/0.441
3o56ZG1cAMP-specific 3',5'-cyclic phosphodiesterase 4B3.1.4.530.441
3q9bB3NAcetylpolyamine amidohydrolase/0.441
3tdaPN0Cytochrome P450 2D6/0.441
3ojxFADNADPH--cytochrome P450 reductase/0.440
3oqkS52Renin3.4.23.150.440
4c2z646Glycylpeptide N-tetradecanoyltransferase 1/0.440