sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3n8w | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3n8w | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 1.000 | |
| 4fm5 | DF0 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.672 | |
| 2ayl | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.652 | |
| 1eqg | IBP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.640 | |
| 1ht8 | 34C | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.640 | |
| 1eqh | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.633 | |
| 3rr3 | FLR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.614 | |
| 1q4g | BFL | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.612 | |
| 3ntg | D72 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.610 | |
| 3pgh | FLP | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.601 | |
| 2oye | IM8 | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.599 | |
| 4cox | IMN | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.598 | |
| 3n8z | FLP | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.597 | |
| 3q7d | NPX | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.595 | |
| 3n8x | NIM | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.589 | |
| 3ln1 | CEL | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.578 | |
| 4rrx | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.578 | |
| 3mqe | 416 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.576 | |
| 5ikr | ID8 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.565 | |
| 2oyu | IMS | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.559 | |
| 4ph9 | IBP | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.558 | |
| 4oty | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.552 | |
| 3kk6 | CEL | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.520 | |
| 6cox | S58 | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.519 | |
| 4rrw | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.512 | |
| 4rrz | LUR | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.512 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.496 | |
| 3n8y | DIF | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.488 | |
| 1pxx | DIF | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.481 | |
| 4m10 | ICD | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.480 | |
| 3ln0 | 52B | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.479 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.477 | |
| 1qiq | ACC | Isopenicillin N synthase | 1.21.3.1 | 0.473 | |
| 5ikq | JMS | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.471 | |
| 2jb4 | A14 | Isopenicillin N synthase | 1.21.3.1 | 0.469 | |
| 2cmj | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.467 | |
| 3zoi | M2W | Isopenicillin N synthase | 1.21.3.1 | 0.465 | |
| 1ht5 | FL2 | Prostaglandin G/H synthase 1 | 1.14.99.1 | 0.463 | |
| 2vbd | V10 | Isopenicillin N synthase | 1.21.3.1 | 0.463 | |
| 3hk1 | B64 | Fatty acid-binding protein, adipocyte | / | 0.461 | |
| 1k6p | XN3 | Gag-Pol polyprotein | 3.4.23.16 | 0.460 | |
| 4uz6 | SCR | Palmitoleoyl-protein carboxylesterase NOTUM | / | 0.460 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.458 | |
| 1efv | FAD | Electron transfer flavoprotein subunit alpha, mitochondrial | / | 0.457 | |
| 3zky | WT4 | Isopenicillin N synthase | 1.21.3.1 | 0.457 | |
| 1uzw | CDH | Isopenicillin N synthase | 1.21.3.1 | 0.456 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.456 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.455 | |
| 1cqp | 803 | Integrin alpha-L | / | 0.453 | |
| 4nkv | AER | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.453 | |
| 1iol | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.452 | |
| 2ivi | ACW | Isopenicillin N synthase | 1.21.3.1 | 0.452 | |
| 2y1o | T26 | UDP-N-acetylmuramoylalanine--D-glutamate ligase | 6.3.2.9 | 0.452 | |
| 3g49 | NAP | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.452 | |
| 5ikt | TLF | Prostaglandin G/H synthase 2 | 1.14.99.1 | 0.452 | |
| 1bk0 | ACV | Isopenicillin N synthase | 1.21.3.1 | 0.451 | |
| 1tdu | CB3 | Thymidylate synthase | / | 0.451 | |
| 4q73 | FAD | Bifunctional protein PutA | / | 0.451 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.450 | |
| 3fl8 | RAR | Dihydrofolate reductase | / | 0.450 | |
| 1w06 | W05 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 2vcm | M11 | Isopenicillin N synthase | 1.21.3.1 | 0.449 | |
| 3nwq | 2NC | Gag-Pol polyprotein | 3.4.23.16 | 0.449 | |
| 4l06 | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.449 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.449 | |
| 1n83 | CLR | Nuclear receptor ROR-alpha | / | 0.448 | |
| 2bxi | AZQ | Serum albumin | / | 0.448 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.448 | |
| 1ie8 | KH1 | Vitamin D3 receptor | / | 0.447 | |
| 1ju6 | LYA | Thymidylate synthase | 2.1.1.45 | 0.446 | |
| 1o5r | FR9 | Adenosine deaminase | 3.5.4.4 | 0.446 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.446 | |
| 2npa | MMB | Peroxisome proliferator-activated receptor alpha | / | 0.445 | |
| 1fdw | EST | Estradiol 17-beta-dehydrogenase 1 | 1.1.1.62 | 0.443 | |
| 1pnv | TYD | dTDP-epi-vancosaminyltransferase | 2.4.1.311 | 0.443 | |
| 3vrw | YS5 | Vitamin D3 receptor | / | 0.443 | |
| 4l04 | NAP | Isocitrate dehydrogenase [NADP] cytoplasmic | 1.1.1.42 | 0.443 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.442 | |
| 1hvy | D16 | Thymidylate synthase | 2.1.1.45 | 0.442 | |
| 3stv | 3HO | Methylketone synthase I | / | 0.442 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.442 | |
| 1qjf | ACS | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 2y60 | M8F | Isopenicillin N synthase | 1.21.3.1 | 0.441 | |
| 3anl | NDP | 1-deoxy-D-xylulose 5-phosphate reductoisomerase | 1.1.1.267 | 0.441 | |
| 4dpw | AGS | Mevalonate diphosphate decarboxylase | / | 0.441 | |
| 4jv8 | 1M1 | Retinal rod rhodopsin-sensitive cGMP 3',5'-cyclic phosphodiesterase subunit delta | / | 0.441 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.440 | |
| 2wet | FAD | Tryptophan 5-halogenase | / | 0.440 | |
| 3bej | MUF | Bile acid receptor | / | 0.440 | |
| 4xum | IMN | Peroxisome proliferator-activated receptor gamma | / | 0.440 |