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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3mfuANPPeripheral plasma membrane protein CASK2.7.11.1

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3mfuANPPeripheral plasma membrane protein CASK2.7.11.11.000
3mfsANPPeripheral plasma membrane protein CASK2.7.11.10.663
3mfrANPPeripheral plasma membrane protein CASK2.7.11.10.586
3wowANPCasein kinase II subunit alpha2.7.11.10.519
3c0i3AMPeripheral plasma membrane protein CASK2.7.11.10.508
3c0g3AMPeripheral plasma membrane protein CASK2.7.11.10.507
2vz6FEFCalcium/calmodulin-dependent protein kinase type II subunit alpha2.7.11.170.502
2vu3LZECyclin-dependent kinase 22.7.11.220.496
3nszANPCasein kinase II subunit alpha2.7.11.10.496
1q97ATPSerine/threonine-protein kinase SKY12.7.11.10.491
1pyxANPGlycogen synthase kinase-3 beta2.7.11.260.486
2pvnP63Casein kinase II subunit alpha2.7.11.10.485
4bcmT7ZCyclin-dependent kinase 22.7.11.220.485
2iw94SPCyclin-dependent kinase 22.7.11.220.480
4jr7GNPCasein kinase II subunit alpha2.7.11.10.480
1h1r6CPCyclin-dependent kinase 22.7.11.220.478
3v8w0G2Tyrosine-protein kinase ITK/TSK2.7.10.20.477
4ez50RSCyclin-dependent kinase 62.7.11.220.477
3uli1N3Cyclin-dependent kinase 22.7.11.220.476
3be9P04Casein kinase II subunit alpha2.7.11.10.472
4u97STUInterleukin-1 receptor-associated kinase 42.7.11.10.472
1e9hINRCyclin-dependent kinase 22.7.11.220.471
1q8yADPSerine/threonine-protein kinase SKY12.7.11.10.471
3vs2VSBTyrosine-protein kinase HCK2.7.10.20.471
4bchT7ZCyclin-dependent kinase 92.7.11.220.471
2nrySTUInterleukin-1 receptor-associated kinase 42.7.11.10.470
2w05FRTCyclin-dependent kinase 22.7.11.220.468
4oa9ANPProtein BRASSINOSTEROID INSENSITIVE 12.7.10.10.468
4bcnT9NCyclin-dependent kinase 22.7.11.220.467
1oi9N20Cyclin-dependent kinase 22.7.11.220.466
2iw84SPCyclin-dependent kinase 22.7.11.220.466
1jstATPCyclin-dependent kinase 22.7.11.220.465
4eomATPCyclin-dependent kinase 22.7.11.220.465
5cvhADPCasein kinase II subunit alpha2.7.11.10.464
3nup3NUCyclin-dependent kinase 62.7.11.220.463
1dawANPCasein kinase II subunit alpha2.7.11.10.462
1pkdUCNCyclin-dependent kinase 22.7.11.220.461
1u54ACPActivated CDC42 kinase 1/0.461
2zv2609Calcium/calmodulin-dependent protein kinase kinase 22.7.11.170.461
5dt3ATPAurora kinase A2.7.11.10.461
2phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.460
4jqeANPCasein kinase II subunit alpha2.7.11.10.460
1h1s4SPCyclin-dependent kinase 22.7.11.220.459
2om9AJAPeroxisome proliferator-activated receptor gamma/0.459
3i4bZ48Glycogen synthase kinase-3 beta2.7.11.260.459
1oguST8Cyclin-dependent kinase 22.7.11.220.458
1ol7ADPAurora kinase A2.7.11.10.458
1dayGNPCasein kinase II subunit alpha2.7.11.10.457
1fvv107Cyclin-dependent kinase 22.7.11.220.457
1gih1PUCyclin-dependent kinase 22.7.11.220.457
1lp4ANPCasein kinase II subunit alpha2.7.11.10.457
1ol5ADPAurora kinase A2.7.11.10.457
1qmzATPCyclin-dependent kinase 22.7.11.220.457
3ckxSTUSerine/threonine-protein kinase 242.7.11.10.457
4grb0XGCasein kinase II subunit alpha2.7.11.10.457
4l7sG7KTyrosine-protein kinase ITK/TSK2.7.10.20.457
5drdATPAurora kinase A2.7.11.10.457
4eok4SPCyclin-dependent kinase 22.7.11.220.456
3at3ATKCasein kinase II subunit alpha2.7.11.10.455
4riyADPEpidermal growth factor receptor2.7.10.10.455
2pvlP55Casein kinase II subunit alpha2.7.11.10.454
5dc5B3NHistone deacetylase 83.5.1.980.454
4anmWULCasein kinase II subunit alpha2.7.11.10.453
4hvh19RTyrosine-protein kinase JAK32.7.10.20.453
2h8hH8HProto-oncogene tyrosine-protein kinase Src2.7.10.20.452
4deeADPAurora kinase A2.7.11.10.452
4xhgADPUncharacterized protein/0.452
1di8DTQCyclin-dependent kinase 22.7.11.220.451
1k6tXN1Gag-Pol polyprotein3.4.23.160.451
1phkATPPhosphorylase b kinase gamma catalytic chain, skeletal muscle/heart isoform2.7.11.190.451
3r9dX6BCyclin-dependent kinase 22.7.11.220.451
4bcqTJFCyclin-dependent kinase 22.7.11.220.451
4krcAGSCyclin-dependent protein kinase PHO852.7.11.220.451
4q71FADBifunctional protein PutA/0.451
2etm7PYFocal adhesion kinase 12.7.10.20.450
2qo9ANPEphrin type-A receptor 32.7.10.10.450
3bhh5CPCalcium/calmodulin-dependent protein kinase type II subunit beta2.7.11.170.450
3c50ADPRhodopsin kinase/0.450
4dgmAGICasein kinase II subunit alpha2.7.11.10.450
2py3ACPFibroblast growth factor receptor 2/0.449
3my5RFZCyclin-dependent kinase 22.7.11.220.449
4dit0KDGlycogen synthase kinase-3 beta2.7.11.260.449
4eooATPCyclin-dependent kinase 22.7.11.220.449
1oiyN41Cyclin-dependent kinase 22.7.11.220.448
4erwSTUCyclin-dependent kinase 22.7.11.220.448
4utdACPAurora kinase A2.7.11.10.448
5dt4ATPAurora kinase A2.7.11.10.448
1q41IXMGlycogen synthase kinase-3 beta2.7.11.260.447
2i40BLZCyclin-dependent kinase 22.7.11.220.447
2uzbC75Cyclin-dependent kinase 22.7.11.220.447
4fl1ANPTyrosine-protein kinase SYK2.7.10.20.447
2j0m4STFocal adhesion kinase 12.7.10.20.446
3frqERYErythromycin resistance repressor protein/0.446
4k33ACPFibroblast growth factor receptor 32.7.10.10.446
1oiuN76Cyclin-dependent kinase 22.7.11.220.445
3ddpRC8Cyclin-dependent kinase 22.7.11.220.445
3tqhNDPQuinone oxidoreductase/0.445
3u4uLNHCasein kinase II subunit alpha2.7.11.10.445
4dgo0JWCasein kinase II subunit alpha2.7.11.10.445
4jia1K3Tyrosine-protein kinase JAK2/0.445
4oavACP2-5A-dependent ribonuclease3.1.260.445
4qmlANPSerine/threonine-protein kinase 242.7.11.10.445
4y12AGSSerine/threonine-protein kinase PknG2.7.11.10.445
1aq1STUCyclin-dependent kinase 22.7.11.220.444
1v1k3FPCyclin-dependent kinase 22.7.11.220.444
2c6tDT5Cyclin-dependent kinase 22.7.11.220.444
5cshATPCasein kinase II subunit alpha2.7.11.10.444
5dn3ATPAurora kinase A2.7.11.10.444
2f2cAP9Cyclin-dependent kinase 62.7.11.220.443
2vn9GVDCalcium/calmodulin-dependent protein kinase type II subunit delta2.7.11.170.443
3v5j0F2Tyrosine-protein kinase ITK/TSK2.7.10.20.443
4iirANPSerine/threonine-protein kinase PRP4 homolog2.7.11.10.443
4ix5ANPUncharacterized protein/0.443
5dpvSKEAurora kinase A2.7.11.10.443
1bygSTUTyrosine-protein kinase CSK/0.442
2cf6NAPCinnamyl alcohol dehydrogenase 51.1.1.1950.442
2fvdLIACyclin-dependent kinase 22.7.11.220.442
3o0g3O0Cyclin-dependent-like kinase 52.7.11.10.442
3vs7KS1Tyrosine-protein kinase HCK2.7.10.20.442
4dgnLU2Casein kinase II subunit alpha2.7.11.10.442
1ad5ANPTyrosine-protein kinase HCK2.7.10.20.441
3q9xEMOCasein kinase II subunit alpha2.7.11.10.441
4achKDIGlycogen synthase kinase-3 beta2.7.11.260.441
4yzcSTUSerine/threonine-protein kinase/endoribonuclease IRE12.7.11.10.441
5ajqDB8Serine/threonine-protein kinase 102.7.11.10.441
1gy3ATPCyclin-dependent kinase 22.7.11.220.440
1o6yACPSerine/threonine-protein kinase PknB2.7.11.10.440
3keuATPPyridoxal kinase2.7.1.350.440
3qrtX14Cyclin-dependent kinase 22.7.11.220.440
4bcoT6QCyclin-dependent kinase 22.7.11.220.440
5kghACOPredicted acetyltransferase/0.440