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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3lffZ83Mitogen-activated protein kinase 14

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3lffZ83Mitogen-activated protein kinase 14/1.000
3p7bP7BMitogen-activated protein kinase 14/0.521
3gcuR48Mitogen-activated protein kinase 14/0.496
2yisYISMitogen-activated protein kinase 14/0.495
3uvr06FMitogen-activated protein kinase 14/0.488
3t1tGDPProbable gliding protein mglA/0.479
3w33W19Epidermal growth factor receptor2.7.10.10.475
4nmdFDABifunctional protein PutA/0.474
3f3sNADLambda-crystallin homolog/0.472
3p7aP7AMitogen-activated protein kinase 14/0.468
3p5kP5KMitogen-activated protein kinase 14/0.466
3gcvSS6Mitogen-activated protein kinase 14/0.463
3jzdNADMaleylacetate reductase/0.463
3nnwEDDMitogen-activated protein kinase 14/0.462
4ki8ADP60 kDa chaperonin/0.461
3ntgD72Prostaglandin G/H synthase 21.14.99.10.460
4dpwAGSMevalonate diphosphate decarboxylase/0.460
4rpgFADUDP-galactopyranose mutase5.4.99.90.460
2yxuATPPyridoxal kinase2.7.1.350.458
1l3iSAHProbable cobalt-precorrin-6B C(15)-methyltransferase (decarboxylating)/0.456
2c6eHPMAurora kinase A2.7.11.10.456
3hv4L51Mitogen-activated protein kinase 14/0.456
1xddAAYIntegrin alpha-L/0.455
4id71G0Activated CDC42 kinase 1/0.453
4xumIMNPeroxisome proliferator-activated receptor gamma/0.453
3npcB96Mitogen-activated protein kinase 92.7.11.240.452
3qv1NADGlyceraldehyde-3-phosphate dehydrogenase GAPA1, chloroplastic1.2.1.130.452
4y8vADPAcyl-CoA synthetase (NDP forming)/0.452
3h86AP5Adenylate kinase/0.451
3zc3NAPFerredoxin--NADP reductase1.18.1.20.451
1jvsNDP1-deoxy-D-xylulose 5-phosphate reductoisomerase1.1.1.2670.450
4mb2ATPUncharacterized protein/0.450
4oagADPMitochondrial dynamics protein MID51/0.450
1f20NAPNitric oxide synthase, brain1.14.13.390.449
1wuuANPGalactokinase2.7.1.60.448
2ch6ADPN-acetyl-D-glucosamine kinase2.7.1.590.448
3fhyATPPyridoxal kinase2.7.1.350.448
5kjfNAJAlcohol dehydrogenase E chain1.1.1.10.448
3hazFADBifunctional protein PutA/0.447
3p7cP7CMitogen-activated protein kinase 14/0.447
1powFADPyruvate oxidase1.2.3.30.446
2c59NADGDP-mannose 3,5-epimerase5.1.3.180.446
1hdcCBO3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.445
2y3sTIRTamL/0.445
4fl2ANPTyrosine-protein kinase SYK2.7.10.20.445
4oaqNDPR-specific carbonyl reductase/0.445
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.444
1kv2B96Mitogen-activated protein kinase 14/0.444
3poz03PEpidermal growth factor receptor2.7.10.10.444
3vs6VSHTyrosine-protein kinase HCK2.7.10.20.444
5cnnANPEpidermal growth factor receptor2.7.10.10.444
4h1m0YJProtein-tyrosine kinase 2-beta2.7.10.20.443
1tj0FADBifunctional protein PutA1.5.5.20.442
2hfpNSIPeroxisome proliferator-activated receptor gamma/0.442
3zxtACPDeath-associated protein kinase 12.7.11.10.442
4wdb2AM2',3'-cyclic-nucleotide 3'-phosphodiesterase3.1.4.370.442
2pd8FADVivid PAS protein VVD/0.441
3cgbFADCoenzyme A disulfide reductase/0.441
3sdkP3NProteasome subunit beta type-53.4.25.10.441
3sdkP3NProteasome subunit beta type-63.4.25.10.441
1fm6BRLPeroxisome proliferator-activated receptor gamma/0.440
1hk1T44Serum albumin/0.440
1sxjAGSReplication factor C subunit 1/0.440
3e2sFADBifunctional protein PutA1.5.5.20.440