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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3l70JZVCytochrome b

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity
Align
3l70JZVCytochrome b/1.000
3tguWF3Cytochrome b/0.625
3l71AZOCytochrome b/0.609
1sqbAZOCytochrome b/0.561
1sqpMYXCytochrome b/0.555
3h1jSMACytochrome b/0.496
4j6cSTRCytochrome P450 monooxygenase/0.484
4iaq2GM5-hydroxytryptamine receptor 1B/0.483
4nc3ERM5-hydroxytryptamine receptor 2B/0.483
3abaFLICytochrome P450/0.479
2azzTCHPhospholipase A2, major isoenzyme3.1.1.40.474
3ar5TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.473
2hrcCHDFerrochelatase, mitochondrial4.99.1.10.470
3gyuDL7Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.470
1pkfEPDEpothilone C/D epoxidase1.140.467
1iyzNDPProbable quinone oxidoreductase/0.463
4jib1L6cGMP-dependent 3',5'-cyclic phosphodiesterase3.1.4.170.463
4jqh1MFAlr2278 protein/0.462
2y46MIVMycinamicin IV hydroxylase/epoxidase/0.461
2azyCHDPhospholipase A2, major isoenzyme3.1.1.40.460
1q5dEPBEpothilone C/D epoxidase1.140.459
4iarERM5-hydroxytryptamine receptor 1B/0.458
4ib4ERM5-hydroxytryptamine receptor 2B/0.458
4qe6JN3Bile acid receptor/0.458
1diuBDMDihydrofolate reductase1.5.1.30.457
1fp1HCCIsoliquiritigenin 2'-O-methyltransferase/0.457
3gytDL4Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily/0.457
1fmlRTLRetinol dehydratase/0.456
1rf9DBRCamphor 5-monooxygenase1.14.15.10.455
1sqqOSTCytochrome b/0.455
2ibzSMACytochrome b/0.455
3tmz06XCytochrome P450 2B41.14.14.10.455
4qa0SHHHistone deacetylase 83.5.1.980.455
2aibERGBeta-elicitin cinnamomin/0.454
2po7CHDFerrochelatase, mitochondrial4.99.1.10.454
3p3zP3ZPutative cytochrome P450/0.454
3sgtP09Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)/0.454
4nky3QZSteroid 17-alpha-hydroxylase/17,20 lyase/0.454
2b00GCHPhospholipase A2, major isoenzyme3.1.1.40.453
2h42VIAcGMP-specific 3',5'-cyclic phosphodiesterase/0.453
2i4zDRHPeroxisome proliferator-activated receptor gamma/0.452
3bhlTHGThymidylate synthase/0.452
3vtdTKDVitamin D3 receptor/0.451
4cjx9L9C-1-tetrahydrofolate synthase, cytoplasmic, putative/0.451
1cbrREACellular retinoic acid-binding protein 1/0.450
1tw2ERTCarminomycin 4-O-methyltransferase DnrK2.1.1.2920.450
1re9DSOCamphor 5-monooxygenase1.14.15.10.449
3td8D2RDihydrofolate reductase1.5.1.30.449
5dc5B3NHistone deacetylase 83.5.1.980.449
2w4qCBWProstaglandin reductase 21.3.1.480.448
4bb5HD2Corticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.448
4j6bPLOCytochrome P450 monooxygenase/0.448
3l6jZ90Alr2278 protein/0.447
5k2bZMAAdenosine receptor A2a/0.447
1lriCLRBeta-elicitin cryptogein/0.446
1oc1ASVIsopenicillin N synthase1.21.3.10.446
3a1l2CCCytochrome P450/0.446
3fkoFKOMitogen-activated protein kinase 14/0.446
3p6nDSOCamphor 5-monooxygenase1.14.15.10.445
1kzjCB3Thymidylate synthase/0.444
2pr2DG1Enoyl-[acyl-carrier-protein] reductase [NADH]1.3.1.90.444
3p9tTCLRepressor/0.444
4l9q9TPSerum albumin/0.444
5hs1VORLanosterol 14-alpha demethylase/0.444
5jtbZMAAdenosine receptor A2a/0.444
1fm4DXCMajor pollen allergen Bet v 1-L/0.443
1pp9SMACytochrome b/0.443
2dqsTG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.443
2y98MIVMycinamicin IV hydroxylase/epoxidase/0.443
3p6oETGCamphor 5-monooxygenase1.14.15.10.443
2agvTG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.442
3ar6TG1Sarcoplasmic/endoplasmic reticulum calcium ATPase 13.6.3.80.442
3jynNDPQuinone oxidoreductase/0.442
4isk1JYThymidylate synthase/0.442
1osvCHCBile acid receptor/0.441
2e9cB75Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)2.5.1.310.441
3is9AC7Gag-Pol polyprotein2.7.7.490.441
3tdaPN0Cytochrome P450 2D6/0.441
4hw319GInduced myeloid leukemia cell differentiation protein Mcl-1/0.441
1tduCB3Thymidylate synthase/0.440
2vzmNRBCytochrome P450 monooxygenase PikC/0.440
3nalDBKCalcium-transporting ATPase/0.440
4gevCB3Thymidylate synthase/0.440