sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3l70 | JZV | Cytochrome b |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3l70 | JZV | Cytochrome b | / | 1.000 | |
| 3tgu | WF3 | Cytochrome b | / | 0.625 | |
| 3l71 | AZO | Cytochrome b | / | 0.609 | |
| 1sqb | AZO | Cytochrome b | / | 0.561 | |
| 1sqp | MYX | Cytochrome b | / | 0.555 | |
| 3h1j | SMA | Cytochrome b | / | 0.496 | |
| 4j6c | STR | Cytochrome P450 monooxygenase | / | 0.484 | |
| 4iaq | 2GM | 5-hydroxytryptamine receptor 1B | / | 0.483 | |
| 4nc3 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.483 | |
| 3aba | FLI | Cytochrome P450 | / | 0.479 | |
| 2azz | TCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.474 | |
| 3ar5 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.473 | |
| 2hrc | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.470 | |
| 3gyu | DL7 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.470 | |
| 1pkf | EPD | Epothilone C/D epoxidase | 1.14 | 0.467 | |
| 1iyz | NDP | Probable quinone oxidoreductase | / | 0.463 | |
| 4jib | 1L6 | cGMP-dependent 3',5'-cyclic phosphodiesterase | 3.1.4.17 | 0.463 | |
| 4jqh | 1MF | Alr2278 protein | / | 0.462 | |
| 2y46 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.461 | |
| 2azy | CHD | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.460 | |
| 1q5d | EPB | Epothilone C/D epoxidase | 1.14 | 0.459 | |
| 4iar | ERM | 5-hydroxytryptamine receptor 1B | / | 0.458 | |
| 4ib4 | ERM | 5-hydroxytryptamine receptor 2B | / | 0.458 | |
| 4qe6 | JN3 | Bile acid receptor | / | 0.458 | |
| 1diu | BDM | Dihydrofolate reductase | 1.5.1.3 | 0.457 | |
| 1fp1 | HCC | Isoliquiritigenin 2'-O-methyltransferase | / | 0.457 | |
| 3gyt | DL4 | Nuclear hormone receptor of the steroid/thyroid hormone receptors superfamily | / | 0.457 | |
| 1fml | RTL | Retinol dehydratase | / | 0.456 | |
| 1rf9 | DBR | Camphor 5-monooxygenase | 1.14.15.1 | 0.455 | |
| 1sqq | OST | Cytochrome b | / | 0.455 | |
| 2ibz | SMA | Cytochrome b | / | 0.455 | |
| 3tmz | 06X | Cytochrome P450 2B4 | 1.14.14.1 | 0.455 | |
| 4qa0 | SHH | Histone deacetylase 8 | 3.5.1.98 | 0.455 | |
| 2aib | ERG | Beta-elicitin cinnamomin | / | 0.454 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.454 | |
| 3p3z | P3Z | Putative cytochrome P450 | / | 0.454 | |
| 3sgt | P09 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | / | 0.454 | |
| 4nky | 3QZ | Steroid 17-alpha-hydroxylase/17,20 lyase | / | 0.454 | |
| 2b00 | GCH | Phospholipase A2, major isoenzyme | 3.1.1.4 | 0.453 | |
| 2h42 | VIA | cGMP-specific 3',5'-cyclic phosphodiesterase | / | 0.453 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.452 | |
| 3bhl | THG | Thymidylate synthase | / | 0.452 | |
| 3vtd | TKD | Vitamin D3 receptor | / | 0.451 | |
| 4cjx | 9L9 | C-1-tetrahydrofolate synthase, cytoplasmic, putative | / | 0.451 | |
| 1cbr | REA | Cellular retinoic acid-binding protein 1 | / | 0.450 | |
| 1tw2 | ERT | Carminomycin 4-O-methyltransferase DnrK | 2.1.1.292 | 0.450 | |
| 1re9 | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.449 | |
| 3td8 | D2R | Dihydrofolate reductase | 1.5.1.3 | 0.449 | |
| 5dc5 | B3N | Histone deacetylase 8 | 3.5.1.98 | 0.449 | |
| 2w4q | CBW | Prostaglandin reductase 2 | 1.3.1.48 | 0.448 | |
| 4bb5 | HD2 | Corticosteroid 11-beta-dehydrogenase isozyme 1 | 1.1.1.146 | 0.448 | |
| 4j6b | PLO | Cytochrome P450 monooxygenase | / | 0.448 | |
| 3l6j | Z90 | Alr2278 protein | / | 0.447 | |
| 5k2b | ZMA | Adenosine receptor A2a | / | 0.447 | |
| 1lri | CLR | Beta-elicitin cryptogein | / | 0.446 | |
| 1oc1 | ASV | Isopenicillin N synthase | 1.21.3.1 | 0.446 | |
| 3a1l | 2CC | Cytochrome P450 | / | 0.446 | |
| 3fko | FKO | Mitogen-activated protein kinase 14 | / | 0.446 | |
| 3p6n | DSO | Camphor 5-monooxygenase | 1.14.15.1 | 0.445 | |
| 1kzj | CB3 | Thymidylate synthase | / | 0.444 | |
| 2pr2 | DG1 | Enoyl-[acyl-carrier-protein] reductase [NADH] | 1.3.1.9 | 0.444 | |
| 3p9t | TCL | Repressor | / | 0.444 | |
| 4l9q | 9TP | Serum albumin | / | 0.444 | |
| 5hs1 | VOR | Lanosterol 14-alpha demethylase | / | 0.444 | |
| 5jtb | ZMA | Adenosine receptor A2a | / | 0.444 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.443 | |
| 1pp9 | SMA | Cytochrome b | / | 0.443 | |
| 2dqs | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.443 | |
| 2y98 | MIV | Mycinamicin IV hydroxylase/epoxidase | / | 0.443 | |
| 3p6o | ETG | Camphor 5-monooxygenase | 1.14.15.1 | 0.443 | |
| 2agv | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.442 | |
| 3ar6 | TG1 | Sarcoplasmic/endoplasmic reticulum calcium ATPase 1 | 3.6.3.8 | 0.442 | |
| 3jyn | NDP | Quinone oxidoreductase | / | 0.442 | |
| 4isk | 1JY | Thymidylate synthase | / | 0.442 | |
| 1osv | CHC | Bile acid receptor | / | 0.441 | |
| 2e9c | B75 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | 2.5.1.31 | 0.441 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.441 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.441 | |
| 4hw3 | 19G | Induced myeloid leukemia cell differentiation protein Mcl-1 | / | 0.441 | |
| 1tdu | CB3 | Thymidylate synthase | / | 0.440 | |
| 2vzm | NRB | Cytochrome P450 monooxygenase PikC | / | 0.440 | |
| 3nal | DBK | Calcium-transporting ATPase | / | 0.440 | |
| 4gev | CB3 | Thymidylate synthase | / | 0.440 |