sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3inw | JZB | Heat shock protein HSP 90-alpha |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3inw | JZB | Heat shock protein HSP 90-alpha | / | 1.000 | |
| 3inx | JZC | Heat shock protein HSP 90-alpha | / | 0.737 | |
| 1uy8 | PU5 | Heat shock protein HSP 90-alpha | / | 0.681 | |
| 1uym | PU3 | Heat shock protein HSP 90-beta | / | 0.671 | |
| 1uye | PU9 | Heat shock protein HSP 90-alpha | / | 0.650 | |
| 4nh8 | 2LC | Heat shock protein HSP 90-alpha | / | 0.648 | |
| 1uy7 | PU4 | Heat shock protein HSP 90-alpha | / | 0.647 | |
| 2fwy | H64 | Heat shock protein HSP 90-alpha | / | 0.634 | |
| 2fwz | H71 | Heat shock protein HSP 90-alpha | / | 0.633 | |
| 2ykj | YKJ | Heat shock protein HSP 90-alpha | / | 0.633 | |
| 3ft8 | MOJ | Heat shock protein HSP 90-alpha | / | 0.633 | |
| 1uy9 | PU6 | Heat shock protein HSP 90-alpha | / | 0.625 | |
| 3o0i | P54 | Heat shock protein HSP 90-alpha | / | 0.625 | |
| 4efu | EFU | Heat shock protein HSP 90-alpha | / | 0.625 | |
| 1uyk | PUX | Heat shock protein HSP 90-alpha | / | 0.619 | |
| 1uyd | PU8 | Heat shock protein HSP 90-alpha | / | 0.616 | |
| 1uyf | PU1 | Heat shock protein HSP 90-alpha | / | 0.613 | |
| 2h55 | DZ8 | Heat shock protein HSP 90-alpha | / | 0.613 | |
| 1uyc | PU7 | Heat shock protein HSP 90-alpha | / | 0.609 | |
| 1uyh | PU0 | Heat shock protein HSP 90-alpha | / | 0.606 | |
| 3mnr | SD1 | Heat shock protein HSP 90-alpha | / | 0.605 | |
| 3o6o | 94M | Heat shock protein 83 | / | 0.605 | |
| 2wi7 | 2KL | Heat shock protein HSP 90-alpha | / | 0.604 | |
| 2ykc | YKC | Heat shock protein HSP 90-alpha | / | 0.604 | |
| 3hz5 | Z64 | Heat shock protein HSP 90-alpha | / | 0.601 | |
| 4awo | 99B | Heat shock protein HSP 90-alpha | / | 0.595 | |
| 2yke | YKE | Heat shock protein HSP 90-alpha | / | 0.594 | |
| 4eft | EFT | Heat shock protein HSP 90-alpha | / | 0.594 | |
| 1uy6 | PU3 | Heat shock protein HSP 90-alpha | / | 0.587 | |
| 2wi4 | ZZ4 | Heat shock protein HSP 90-alpha | / | 0.584 | |
| 3d0b | SNX | Heat shock protein HSP 90-alpha | / | 0.580 | |
| 2yki | YKI | Heat shock protein HSP 90-alpha | / | 0.575 | |
| 3qdd | 94M | Heat shock protein HSP 90-alpha | / | 0.574 | |
| 4awp | 99A | Heat shock protein HSP 90-alpha | / | 0.571 | |
| 4awq | 592 | Heat shock protein HSP 90-alpha | / | 0.567 | |
| 2qg2 | A91 | Heat shock protein HSP 90-alpha | / | 0.566 | |
| 4bqg | 50Q | Heat shock protein HSP 90-alpha | / | 0.565 | |
| 2ykb | YKB | Heat shock protein HSP 90-alpha | / | 0.554 | |
| 3q5k | D1U | Heat shock protein 83-1 | / | 0.554 | |
| 1uyi | PUZ | Heat shock protein HSP 90-alpha | / | 0.544 | |
| 4hy6 | FJ1 | Heat shock protein HSP 90-alpha | / | 0.543 | |
| 2yjx | YJX | Heat shock protein HSP 90-alpha | / | 0.541 | |
| 3opd | HIE | Heat shock protein 83 | / | 0.532 | |
| 3hz1 | 37D | Heat shock protein HSP 90-alpha | / | 0.518 | |
| 2yk2 | YJW | Heat shock protein HSP 90-alpha | / | 0.505 | |
| 2yee | 2EC | Heat shock protein HSP 90-alpha | / | 0.494 | |
| 2yk2 | YJX | Heat shock protein HSP 90-alpha | / | 0.490 | |
| 2yej | ZZ3 | Heat shock protein HSP 90-alpha | / | 0.484 | |
| 2w9s | TOP | Dihydrofolate reductase type 1 from Tn4003 | 1.5.1.3 | 0.473 | |
| 1guf | NDP | Enoyl-[acyl-carrier-protein] reductase 1, mitochondrial | 1.3.1.10 | 0.471 | |
| 2yei | XQI | Heat shock protein HSP 90-alpha | / | 0.470 | |
| 1rv1 | IMZ | E3 ubiquitin-protein ligase Mdm2 | 6.3.2 | 0.467 | |
| 2i4z | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.464 | |
| 2znn | S44 | Peroxisome proliferator-activated receptor alpha | / | 0.464 | |
| 2yej | XQK | Heat shock protein HSP 90-alpha | / | 0.461 | |
| 5itz | LOC | Tubulin beta-2B chain | / | 0.457 | |
| 1yc4 | 43P | Heat shock protein HSP 90-alpha | / | 0.456 | |
| 2om9 | AJA | Peroxisome proliferator-activated receptor gamma | / | 0.456 | |
| 4z1f | H71 | Heat shock protein 75 kDa, mitochondrial | / | 0.456 | |
| 2hwr | DRD | Peroxisome proliferator-activated receptor gamma | / | 0.455 | |
| 2po7 | CHD | Ferrochelatase, mitochondrial | 4.99.1.1 | 0.455 | |
| 2z3u | CRR | Cytochrome P450 | / | 0.455 | |
| 2f4b | EHA | Peroxisome proliferator-activated receptor gamma | / | 0.454 | |
| 4jql | VJ6 | Heat shock protein HSP 90-alpha | / | 0.453 | |
| 2i4p | DRH | Peroxisome proliferator-activated receptor gamma | / | 0.451 | |
| 1knu | YPA | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 2pob | GW4 | Peroxisome proliferator-activated receptor gamma | / | 0.450 | |
| 3is9 | AC7 | Gag-Pol polyprotein | 2.7.7.49 | 0.450 | |
| 1h66 | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1kbo | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.447 | |
| 1qbg | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.445 | |
| 1zw9 | H64 | ATP-dependent molecular chaperone HSP82 | / | 0.445 | |
| 3ssn | MVI | Mycinamicin VI 2''-O-methyltransferase | / | 0.445 | |
| 1fm4 | DXC | Major pollen allergen Bet v 1-L | / | 0.444 | |
| 1k74 | 544 | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 1nyx | DRF | Peroxisome proliferator-activated receptor gamma | / | 0.444 | |
| 2yeg | XQG | Heat shock protein HSP 90-alpha | / | 0.444 | |
| 4bb3 | KKA | Isopenicillin N synthase | 1.21.3.1 | 0.444 | |
| 3hhu | 819 | Heat shock protein HSP 90-alpha | / | 0.443 | |
| 3tda | PN0 | Cytochrome P450 2D6 | / | 0.443 | |
| 3vn2 | TLS | Peroxisome proliferator-activated receptor gamma | / | 0.443 | |
| 4uym | VOR | 14-alpha sterol demethylase Cyp51B | / | 0.443 | |
| 1kkq | 471 | Peroxisome proliferator-activated receptor alpha | / | 0.442 | |
| 2qo4 | CHD | Fatty acid-binding protein 10-A, liver basic | / | 0.441 | |
| 3ekr | PY9 | Heat shock protein HSP 90-alpha | / | 0.441 | |
| 3vsp | EK8 | Peroxisome proliferator-activated receptor gamma | / | 0.441 | |
| 2nq8 | ZID | Enoyl-ACP reductase | / | 0.440 | |
| 5a4k | FAD | NAD(P)H dehydrogenase [quinone] 1 | 1.6.5.2 | 0.440 |