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sc-PDB

An Annotated Database of Druggable Binding Sites from the Protein DataBank

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Distribution of Binding site similarity measured by Shaper
You can zoom onto the graph by using the mouse to make a selection

Binding Sites are compared using Shaper.
For more information, please see the following publication: Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44

Reference Protein Data Bank Entry :
PDB IDHETUniprot NameEC Number
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase

Complex with similar binding sites

PDB ID HET Uniprot Name EC Number Binding Site
Similarity		 Align
3iahNAPPutative oxoacyl-(Acyl carrier protein) reductase/1.000
3gy0NAPNAD(P)-dependent oxidoreductase/0.579
3bhiNAPCarbonyl reductase [NADPH] 11.1.1.1840.566
4hwkNAPSepiapterin reductase1.1.1.1530.566
4j7uNAPSepiapterin reductase1.1.1.1530.559
4c7kNAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.556
4i5eNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.555
1cydNDPCarbonyl reductase [NADPH] 21.1.1.1840.553
4j7xNAPSepiapterin reductase1.1.1.1530.548
3p19NDPPutative blue fluorescent protein/0.535
2dknNAI3-alpha-hydroxysteroid dehydrogenase/0.531
1snyNAPLD36273p/0.530
3d3wNAPL-xylulose reductase1.1.1.100.530
1w4zNAPPutative ketoacyl reductase1.3.10.527
3qrwNDPPutative ketoacyl reductase1.3.10.527
5idwNAPShort-chain dehydrogenase/reductase SDR/0.524
1ae1NAPTropinone reductase 1/0.522
1xkqNDPUncharacterized protein/0.522
1xseNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.521
1pr9NAPL-xylulose reductase1.1.1.100.520
1n5dNDPCarbonyl reductase [NADPH] 1/0.519
1ipeNDPTropinone reductase 21.1.1.2360.515
1oaaNAPSepiapterin reductase1.1.1.1530.512
4rf2NAPNADPH dependent R-specific alcohol dehydrogenase/0.512
1wntNAPL-xylulose reductase1.1.1.100.511
3g49NAPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.511
4bmvNAPShort-chain dehydrogenase/0.510
1x7gNAPPutative ketoacyl reductase1.3.10.508
3f1kNAPUncharacterized oxidoreductase YciK10.508
3qwfNAP17beta-hydroxysteroid dehydrogenase/0.508
1xg5NAPDehydrogenase/reductase SDR family member 11/0.506
2yutNAPPutative short-chain oxidoreductase/0.502
4bmsNAPAlclohol dehydrogenase/short-chain dehydrogenase/0.501
3o4rNAPDehydrogenase/reductase SDR family member 41.1.1.1840.500
4dc1NDPPutative ketoacyl reductase1.3.10.496
4jbiNDPAlcohol dehydrogenase (Zinc)/0.495
4z3dNDPCarbonyl reductase [NADPH] 11.1.1.1840.495
2dteNAIGlucose 1-dehydrogenase related protein/0.494
2rbeNDPCorticosteroid 11-beta-dehydrogenase isozyme 11.1.1.1460.494
3toxNAPPutative oxidoreductase/0.494
4fj1NAP17beta-hydroxysteroid dehydrogenase/0.493
4is3NAD3alpha-hydroxy bile acid-CoA-ester 3-dehydrogenase 21.17.98.10.490
2wdzNADGalactitol dehydrogenase/0.489
2zatNAPDehydrogenase/reductase SDR family member 41.1.1.1840.487
4fj0NAP17beta-hydroxysteroid dehydrogenase/0.487
3l77NJPShort-chain alcohol dehydrogenase/0.486
1vl8NAPOxidoreductase, short chain dehydrogenase/reductase family/0.485
3sjuNDPKeto reductase/0.485
4qecNAPElxO/0.483
4fj2NAP17beta-hydroxysteroid dehydrogenase/0.482
1edoNAP3-oxoacyl-[acyl-carrier-protein] reductase 1, chloroplastic1.1.1.1000.479
3tn7NJPShort-chain alcohol dehydrogenase/0.479
1x7hNDPPutative ketoacyl reductase1.3.10.478
2bd0NAPSepiapterin reductase/0.477
5jlaNADPutative short-chain dehydrogenase/reductase/0.476
3w8eNAD3-hydroxybutyrate dehydrogenase/0.475
3lqfNADGalactitol dehydrogenase/0.474
1g0nNDPTetrahydroxynaphthalene reductase1.1.1.2520.473
2hrbNAPCarbonyl reductase [NADPH] 31.1.1.1840.472
2jahNDPClavaldehyde dehydrogenase/0.471
4o0lNDPNADPH-dependent 3-quinuclidinone reductase/0.470
4fn4NADShort chain dehydrogenase/0.469
4nbuNAI3-oxoacyl-(Acyl-carrier-protein) reductase/0.469
1e6wNAD3-hydroxyacyl-CoA dehydrogenase type-21.1.1.350.467
3uceNDPDehydrogenase/0.467
3rkuNAPNADP-dependent 3-hydroxy acid dehydrogenase/0.465
4ej0NAPADP-L-glycero-D-manno-heptose-6-epimerase/0.462
2ztmNADD(-)-3-hydroxybutyrate dehydrogenase/0.461
2wsbNADGalactitol dehydrogenase/0.460
2ydxNAPMethionine adenosyltransferase 2 subunit beta/0.460
4gh5NADShort-chain dehydrogenase/reductase SDR/0.460
1nffNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.456
2q2vNADBeta-D-hydroxybutyrate dehydrogenase/0.455
3ai3NDPNADPH-sorbose reductase/0.454
1h5qNAPNADP-dependent mannitol dehydrogenase1.1.1.1380.453
1iy8NADLevodione reductase/0.453
4iqgNAPShort-chain dehydrogenase/reductase SDR/0.453
2ztlNADD(-)-3-hydroxybutyrate dehydrogenase/0.449
3ai2NDPNADPH-sorbose reductase/0.449
4lisNADUDP-glucose 4-epimerase (Eurofung)/0.449
4pvdNDPNADPH-dependent methylglyoxal reductase GRE2/0.449
4qedNAPElxO/0.448
3a28NADL-2,3-butanediol dehydrogenase1.1.1.760.447
1nfrNAD3-alpha-(or 20-beta)-hydroxysteroid dehydrogenase1.1.1.530.444
2ekpNAD2-deoxy-D-gluconate 3-dehydrogenase/0.444
2gdzNAD15-hydroxyprostaglandin dehydrogenase [NAD(+)]1.1.1.1410.444
2p5uNADUDP-glucose 4-epimerase/0.444
3vdqNAD3-hydroxybutyrate dehydrogenase/0.444
3w8fNAD3-hydroxybutyrate dehydrogenase/0.444
5jsfNAD17-beta-hydroxysteroid dehydrogenase 141.1.10.444
4b8zNAPGDP-L-fucose synthase1.1.1.2710.442
3w8dNAD3-hydroxybutyrate dehydrogenase/0.441
3wdsNADNADH-dependent quinuclidinone reductase/0.441
1gegNADDiacetyl reductase [(S)-acetoin forming]1.1.1.3040.440
1rwbNADGlucose 1-dehydrogenase1.1.1.470.440
4impNDPPolyketide synthase extender modules 3-4/0.440