sc-PDB
An Annotated Database of Druggable Binding Sites from the Protein DataBank
An Annotated Database of Druggable Binding Sites from the Protein DataBank
Binding Sites are compared using Shaper.
For more information, please see the following publication:
Desaphy J. et al. Comparison and Druggability Prediction of protein-Ligand Binding sites from pharmacophore-annotated cavity shapes J. Chem. Inf. Model., 2012, 52(8), pp2287-2299
Binding Sites are considered as similar when the similarity value is greater than 0.44
| PDB ID | HET | Uniprot Name | EC Number |
|---|---|---|---|
| 3hy7 | 097 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 |
| PDB ID | HET | Uniprot Name | EC Number | Binding Site Similarity |
Align |
|---|---|---|---|---|---|
| 3hy7 | 097 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 1.000 | |
| 3b8z | 294 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.685 | |
| 3hyg | 099 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.658 | |
| 3hy9 | 098 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.609 | |
| 3ljt | LA3 | A disintegrin and metalloproteinase with thrombospondin motifs 5 | 3.4.24 | 0.567 | |
| 2jih | 097 | A disintegrin and metalloproteinase with thrombospondin motifs 1 | 3.4.24 | 0.518 | |
| 1g05 | BBH | Stromelysin-1 | 3.4.24.17 | 0.476 | |
| 2cf6 | NAP | Cinnamyl alcohol dehydrogenase 5 | 1.1.1.195 | 0.473 | |
| 2fw3 | BUI | Carnitine O-palmitoyltransferase 2, mitochondrial | 2.3.1.21 | 0.470 | |
| 1atl | 0QI | Snake venom metalloproteinase atrolysin-D | 3.4.24.42 | 0.462 | |
| 1g4k | HQQ | Stromelysin-1 | 3.4.24.17 | 0.459 | |
| 2i47 | KGY | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.456 | |
| 4amb | DUD | Putative glycosyl transferase | / | 0.452 | |
| 1hv5 | RXP | Stromelysin-3 | 3.4.24 | 0.451 | |
| 2il2 | LIX | Renin | 3.4.23.15 | 0.451 | |
| 2xs3 | ALA_PHE_THR_SER | Karilysin | 3.4.24 | 0.451 | |
| 3cic | 316 | Beta-secretase 1 | 3.4.23.46 | 0.451 | |
| 4bfx | ZVX | Pantothenate kinase | 2.7.1.33 | 0.450 | |
| 2hyd | ADP | Putative multidrug export ATP-binding/permease protein SAV1866 | 3.6.3 | 0.449 | |
| 1xe5 | 5FE | Plasmepsin-2 | 3.4.23.39 | 0.448 | |
| 2xs4 | ALA_PHE_THR | Karilysin | 3.4.24 | 0.448 | |
| 3em0 | CHD | Fatty acid-binding protein 6, ileal (gastrotropin) | / | 0.447 | |
| 3tne | RIT | Candidapepsin-1 | 3.4.23.24 | 0.447 | |
| 2cns | ACO | Ribosomal-protein-alanine acetyltransferase | / | 0.446 | |
| 3ahn | 3A1 | Oligopeptidase | / | 0.446 | |
| 1zxc | IH6 | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.445 | |
| 2q1w | NAD | Putative nucleotide sugar epimerase/ dehydratase | / | 0.445 | |
| 2g24 | 7IG | Renin | 3.4.23.15 | 0.444 | |
| 1rne | C60 | Renin | 3.4.23.15 | 0.443 | |
| 1yb5 | NAP | Quinone oxidoreductase | 1.6.5.5 | 0.443 | |
| 2gjl | FMN | Nitronate monooxygenase | 1.13.12.16 | 0.443 | |
| 2wo8 | 023 | Macrophage metalloelastase | 3.4.24.65 | 0.443 | |
| 3lgp | 50X | Disintegrin and metalloproteinase domain-containing protein 17 | 3.4.24.86 | 0.443 | |
| 1e3e | NAI | Alcohol dehydrogenase 4 | 1.1.1.1 | 0.442 | |
| 1sln | INH | Stromelysin-1 | 3.4.24.17 | 0.442 | |
| 2hiz | LIJ | Beta-secretase 1 | 3.4.23.46 | 0.442 | |
| 3aho | 3A2 | Oligopeptidase | / | 0.442 | |
| 3wqm | B29 | Diterpene synthase | 3.1.7.8 | 0.442 | |
| 2zat | NAP | Dehydrogenase/reductase SDR family member 4 | 1.1.1.184 | 0.441 | |
| 3b70 | NAP | Enoyl reductase LovC | 1 | 0.441 | |
| 3vqs | JT1 | Genome polyprotein | / | 0.441 | |
| 4bfw | ZVW | Pantothenate kinase | 2.7.1.33 | 0.441 | |
| 4q71 | FAD | Bifunctional protein PutA | / | 0.441 | |
| 5dp2 | NAP | CurF | / | 0.441 | |
| 2g1r | 3IG | Renin | 3.4.23.15 | 0.440 |